CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury

The intestine is one of the main target organs involved in the pathological process of heatstroke. CCAAT/enhancer-binding protein homologous protein (CHOP) is involved in endoplasmic reticulum (ER) stress-induced apoptosis. This study aimed to explore the role of CHOP in heatstroke-induced intestina...

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Veröffentlicht in:	Inflammation 2022-04, Vol.45 (2), p.695-711
Hauptverfasser:	Cao, Yan, Fan, Maiying, Pei, Yanfang, Su, Lei, Xiao, Weiwei, Chen, Fang, Huang, Jie, Liu, Xiehong, Gu, Zhengtao, Zhang, Zhongwei, Yuan, Fangfang, Jiang, Yu, Han, Xiaotong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bax protein Bcl-2 protein Biomedical and Life Sciences Biomedicine Caco-2 Cells CCAAT/enhancer-binding protein Cell injury Cell viability Electrical resistivity Endoplasmic reticulum Endoplasmic Reticulum Stress Epithelial cells Gene expression Heat Stroke - complications Heat Stroke - drug therapy Heatstroke Humans Immunology Internal Medicine Intestine L-Lactate dehydrogenase Lactic acid Male Mice mRNA Mucosa Original Original Article Pathology Pharmacology/Toxicology Phenylbutyric acid Protein deficiency Protein expression Proteins Rheumatology Tight junctions Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Ultrastructure Zonula occludens-1 protein
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