Determination of Human Papillomavirus Type 18 Lineage of E6: A Population Study from Iran
The epidemiological studies in Iran on HPV18 nucleotide changes are rare. This type of virus is prevalent in the Iranian population. Therefore, in the present study, we aimed to identify the genetic variability in HPV18 in the E6 region to evaluate the prevalence of lineage distribution and sublinea...
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| creator | Sadat Larijani, Mona Omrani, Mir Davood Soleimani, Rahim Bavand, Anahita Nejadeh, Amir Houshang Ezzatizadeh, Vahid Jamshidi, Mahboubeh Ramezani, Amitis |
| description | The epidemiological studies in Iran on HPV18 nucleotide changes are rare. This type of virus is prevalent in the Iranian population. Therefore, in the present study, we aimed to identify the genetic variability in HPV18 in the E6 region to evaluate the prevalence of lineage distribution and sublineages in a sample population in Iran. Overall, 60 HPV18 confirmed cases were investigated between 2019 and 2021. The specimens were collected, and molecular genotyping was done using the Linear Array HPV Genotyping Test. DNA extraction was performed by a viral DNA/RNA kit. The HPV E6 gene was amplified by using type-specific primers designed according to the HPV18 genome prototype sequence. The sequencing of the E6 region was successfully done on 43 samples which were then compared to the reference sequence. The most frequent sublineage of HPV18 in this study was A4 (69.7%), followed by A1 (18.6%) and A3 (11.6%). Neither A2 nor A5 sublineage was not detected in this study. The related nucleotide acid changes according to the main references were as follows: A3: T104C/T232G/T485C/C549A, A4: T104C/T485C/C549A. The predominance of A lineage with the high frequency of A4 sublineage was found in the present research. The importance of sublineages in susceptibility to a progressive form of infection requires to be more investigated among the different population. |
| doi_str_mv | 10.1155/2022/2839708 |
| format | Article |
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This type of virus is prevalent in the Iranian population. Therefore, in the present study, we aimed to identify the genetic variability in HPV18 in the E6 region to evaluate the prevalence of lineage distribution and sublineages in a sample population in Iran. Overall, 60 HPV18 confirmed cases were investigated between 2019 and 2021. The specimens were collected, and molecular genotyping was done using the Linear Array HPV Genotyping Test. DNA extraction was performed by a viral DNA/RNA kit. The HPV E6 gene was amplified by using type-specific primers designed according to the HPV18 genome prototype sequence. The sequencing of the E6 region was successfully done on 43 samples which were then compared to the reference sequence. The most frequent sublineage of HPV18 in this study was A4 (69.7%), followed by A1 (18.6%) and A3 (11.6%). Neither A2 nor A5 sublineage was not detected in this study. The related nucleotide acid changes according to the main references were as follows: A3: T104C/T232G/T485C/C549A, A4: T104C/T485C/C549A. The predominance of A lineage with the high frequency of A4 sublineage was found in the present research. The importance of sublineages in susceptibility to a progressive form of infection requires to be more investigated among the different population.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/2839708</identifier><identifier>PMID: 35342765</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Asian Americans ; Causes of ; Cellular biology ; Cervical cancer ; Deoxyribonucleic acid ; Distribution ; DNA ; E6 gene ; Epidemiology ; Female ; Genetic aspects ; Genetic variability ; Genetic Variation - genetics ; Genomes ; Genotype & phenotype ; Genotyping ; Human papillomavirus ; Human papillomavirus 18 - genetics ; Humans ; Identification and classification ; Infections ; Iran - epidemiology ; Linear arrays ; Nucleotide sequence ; Nucleotides ; Oncogene Proteins, Viral - genetics ; Papillomavirus infections ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - genetics ; Papillomaviruses ; Pathogens ; Phylogeny ; Population ; Population studies ; Proteins ; Risk factors ; Statistical analysis ; Uterine Cervical Neoplasms ; Viruses</subject><ispartof>BioMed research international, 2022-03, Vol.2022, p.2839708-5</ispartof><rights>Copyright © 2022 Mona Sadat Larijani et al.</rights><rights>COPYRIGHT 2022 John Wiley & Sons, Inc.</rights><rights>Copyright © 2022 Mona Sadat Larijani et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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This type of virus is prevalent in the Iranian population. Therefore, in the present study, we aimed to identify the genetic variability in HPV18 in the E6 region to evaluate the prevalence of lineage distribution and sublineages in a sample population in Iran. Overall, 60 HPV18 confirmed cases were investigated between 2019 and 2021. The specimens were collected, and molecular genotyping was done using the Linear Array HPV Genotyping Test. DNA extraction was performed by a viral DNA/RNA kit. The HPV E6 gene was amplified by using type-specific primers designed according to the HPV18 genome prototype sequence. The sequencing of the E6 region was successfully done on 43 samples which were then compared to the reference sequence. The most frequent sublineage of HPV18 in this study was A4 (69.7%), followed by A1 (18.6%) and A3 (11.6%). Neither A2 nor A5 sublineage was not detected in this study. 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This type of virus is prevalent in the Iranian population. Therefore, in the present study, we aimed to identify the genetic variability in HPV18 in the E6 region to evaluate the prevalence of lineage distribution and sublineages in a sample population in Iran. Overall, 60 HPV18 confirmed cases were investigated between 2019 and 2021. The specimens were collected, and molecular genotyping was done using the Linear Array HPV Genotyping Test. DNA extraction was performed by a viral DNA/RNA kit. The HPV E6 gene was amplified by using type-specific primers designed according to the HPV18 genome prototype sequence. The sequencing of the E6 region was successfully done on 43 samples which were then compared to the reference sequence. The most frequent sublineage of HPV18 in this study was A4 (69.7%), followed by A1 (18.6%) and A3 (11.6%). Neither A2 nor A5 sublineage was not detected in this study. The related nucleotide acid changes according to the main references were as follows: A3: T104C/T232G/T485C/C549A, A4: T104C/T485C/C549A. The predominance of A lineage with the high frequency of A4 sublineage was found in the present research. The importance of sublineages in susceptibility to a progressive form of infection requires to be more investigated among the different population.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35342765</pmid><doi>10.1155/2022/2839708</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1894-6764</orcidid><orcidid>https://orcid.org/0000-0001-5232-4259</orcidid><orcidid>https://orcid.org/0000-0002-0673-9717</orcidid><orcidid>https://orcid.org/0000-0001-5970-0608</orcidid><orcidid>https://orcid.org/0000-0003-3502-8524</orcidid><orcidid>https://orcid.org/0000-0003-3681-5319</orcidid><orcidid>https://orcid.org/0000-0002-7696-8830</orcidid><orcidid>https://orcid.org/0000-0003-0698-690X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Asian Americans Causes of Cellular biology Cervical cancer Deoxyribonucleic acid Distribution DNA E6 gene Epidemiology Female Genetic aspects Genetic variability Genetic Variation - genetics Genomes Genotype & phenotype Genotyping Human papillomavirus Human papillomavirus 18 - genetics Humans Identification and classification Infections Iran - epidemiology Linear arrays Nucleotide sequence Nucleotides Oncogene Proteins, Viral - genetics Papillomavirus infections Papillomavirus Infections - epidemiology Papillomavirus Infections - genetics Papillomaviruses Pathogens Phylogeny Population Population studies Proteins Risk factors Statistical analysis Uterine Cervical Neoplasms Viruses |
| title | Determination of Human Papillomavirus Type 18 Lineage of E6: A Population Study from Iran |
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