In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity

•Summary of the biological mechanisms and processes underpinning hepatotoxicity.•Description of experimental approaches to support the prediction of hepatotoxicity.•Discussion of the role of in silico approaches highlighting challenges to the adoption of these methods.•Proposed framework for the int...

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Veröffentlicht in:	Computational toxicology 2021-11, Vol.20, p.100187, Article 100187
Hauptverfasser:	Bassan, Arianna, Alves, Vinicius M., Amberg, Alexander, Anger, Lennart T., Auerbach, Scott, Beilke, Lisa, Bender, Andreas, Cronin, Mark T.D., Cross, Kevin P., Hsieh, Jui-Hua, Greene, Nigel, Kemper, Raymond, Kim, Marlene T., Mumtaz, Moiz, Noeske, Tobias, Pavan, Manuela, Pletz, Julia, Russo, Daniel P., Sabnis, Yogesh, Schaefer, Markus, Szabo, David T., Valentin, Jean-Pierre, Wichard, Joerg, Williams, Dominic, Woolley, David, Zwickl, Craig, Myatt, Glenn J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Computational toxicology Expert Alerts Hazard identification Hepatotoxicity In Silico In silico toxicology protocols Liver toxicity Organ toxicity QSAR Read-across Risk assessment
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