Pathogenesis and Treatment of Myeloma-Related Bone Disease

Multiple myeloma is a hematologic malignancy of plasma cells that causes bone-destructive lesions and associated skeletal-related events (SREs). The pathogenesis of myeloma-related bone disease (MBD) is the imbalance of the bone-remodeling process, which results from osteoclast activation, osteoblas...

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Veröffentlicht in:	International journal of molecular sciences 2022-03, Vol.23 (6), p.3112
Hauptverfasser:	Gau, Yuh-Ching, Yeh, Tsung-Jang, Hsu, Chin-Mu, Hsiao, Samuel Yien, Hsiao, Hui-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Angiogenesis Apoptosis Biomedical materials Blood cancer Bone diseases Bone Diseases - etiology Bone Diseases - pathology Bone Diseases - therapy Bone marrow Bone remodeling Cell growth Chemokines Cytokines Diphosphonates - therapeutic use Dkk1 protein Health services Humans Interleukins Kinases Ligands Malignancy Microenvironments Molecular modelling Monoclonal antibodies Multiple myeloma Multiple Myeloma - complications Multiple Myeloma - drug therapy Osteoclasts - metabolism Osteopontin Osteoprotegerin Pathogenesis Patients Plasma cells Proteins RANK Ligand - metabolism Review SOST protein TRANCE protein Tumor Microenvironment Vascular endothelial growth factor Wnt protein Wnt Signaling Pathway β-Catenin
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