Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This s...
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| Veröffentlicht in: | International journal of environmental research and public health 2022-03, Vol.19 (6), p.3434 |
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| description | Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults. |
| doi_str_mv | 10.3390/ijerph19063434 |
| format | Article |
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Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph19063434</identifier><identifier>PMID: 35329121</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Aged ; Aging ; Alzheimer's disease ; Bias ; Biomarkers ; Biomarkers - metabolism ; C-reactive protein ; C-Reactive Protein - analysis ; Clinical trials ; Confidence intervals ; Coronaviruses ; COVID-19 ; Cytokines ; Diabetes ; Disease resistance ; Exercise ; Gene expression ; Geriatrics ; Humans ; Infections ; Infectious diseases ; Inflammation ; Interleukin 10 ; Interleukin 6 ; Intervention ; Meta-analysis ; Middle Aged ; Older people ; Physical training ; Proteins ; Randomized Controlled Trials as Topic ; Resistance Training ; Review ; Severe acute respiratory syndrome coronavirus 2 ; Sports training ; Strength training ; Subgroups ; Systematic review ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>International journal of environmental research and public health, 2022-03, Vol.19 (6), p.3434</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-c056aba7f96abe5da9178341fe1d18e4e1ec8a87a2492ecb063ca9320c01f10f3</citedby><cites>FETCH-LOGICAL-c418t-c056aba7f96abe5da9178341fe1d18e4e1ec8a87a2492ecb063ca9320c01f10f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950894/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950894/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35329121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sang-Dol</creatorcontrib><creatorcontrib>Yeun, Young-Ran</creatorcontrib><title>Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults.</description><subject>Adults</subject><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Bias</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Disease resistance</subject><subject>Exercise</subject><subject>Gene expression</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Intervention</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Physical training</subject><subject>Proteins</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Resistance Training</subject><subject>Review</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sports training</subject><subject>Strength training</subject><subject>Subgroups</subject><subject>Systematic review</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdksFu1DAQhiMEoqVw5YgsceGSYsdONuaAtIoWqFQEKss5mnXGrRfH3trOovBEPCZmW6qW04w8n__5PZ6ieMnoKeeSvjVbDLsrJmnDBRePimPWNLQUDWWP7-VHxbMYt5TyVjTyaXHEa15JVrHj4vdKa1QpEq_JBUYTEziFZB3AOOMuiXekKy8QVDJ7JF-DT2gcATeQM6ctjCMkH2bSzcn_MA4jydWVHTDYmSyHyab4jizJtzkmzKhRucne4M-DwmdMUC4d2Dn3PRjIp340v3AgnXcpeGtzug4GbHxePNE54IvbeFJ8_7Bad5_K8y8fz7rleakEa1OpaN3ABhZa5oD1AJItWi6YRjawFgUyVC20C6iErFBt8twUSF5RRZlmVPOT4v2N7m7ajDgozD7A9rtgRghz78H0DyvOXPWXft-3sqatFFngza1A8NcTxtSPJiq0Fhz6KfZVIwSlgi9YRl__h279FPJADlQl6kbwKlOnN5QKPsaA-s4Mo_3fJegfLkG-8Or-E-7wf7_O_wCotbH5</recordid><startdate>20220314</startdate><enddate>20220314</enddate><creator>Kim, Sang-Dol</creator><creator>Yeun, Young-Ran</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220314</creationdate><title>Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</title><author>Kim, Sang-Dol ; Yeun, Young-Ran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-c056aba7f96abe5da9178341fe1d18e4e1ec8a87a2492ecb063ca9320c01f10f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adults</topic><topic>Aged</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Bias</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Clinical trials</topic><topic>Confidence intervals</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Disease resistance</topic><topic>Exercise</topic><topic>Gene expression</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Intervention</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Physical training</topic><topic>Proteins</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Resistance Training</topic><topic>Review</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Sports training</topic><topic>Strength training</topic><topic>Subgroups</topic><topic>Systematic review</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sang-Dol</creatorcontrib><creatorcontrib>Yeun, Young-Ran</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sang-Dol</au><au>Yeun, Young-Ran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2022-03-14</date><risdate>2022</risdate><volume>19</volume><issue>6</issue><spage>3434</spage><pages>3434-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35329121</pmid><doi>10.3390/ijerph19063434</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Aged Aging Alzheimer's disease Bias Biomarkers Biomarkers - metabolism C-reactive protein C-Reactive Protein - analysis Clinical trials Confidence intervals Coronaviruses COVID-19 Cytokines Diabetes Disease resistance Exercise Gene expression Geriatrics Humans Infections Infectious diseases Inflammation Interleukin 10 Interleukin 6 Intervention Meta-analysis Middle Aged Older people Physical training Proteins Randomized Controlled Trials as Topic Resistance Training Review Severe acute respiratory syndrome coronavirus 2 Sports training Strength training Subgroups Systematic review Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
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