p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin

Chemotherapeutic drug-induced p53-dependent crosstalk among tumor cells affects the sensitivity of tumor cells to chemotherapeutic drugs, contributing to chemoresistance. Therefore, pharmacological targeting of p53 may contribute to overcoming drug resistance. The localization of p53 is closely rela...

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Veröffentlicht in:	International journal of molecular sciences 2022-03, Vol.23 (6), p.3290
Hauptverfasser:	Kong, Qinghuan, Yan, Xiaoyu, Cheng, Meiyu, Jiang, Xin, Xu, Long, Shen, Luyan, Yu, Huimei, Sun, Liankun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Autophagy Cancer therapies Carcinoma, Ovarian Epithelial - drug therapy Cell cycle Cell death Cell growth Cell Line, Tumor Chemoresistance Chemotherapy Cisplatin Cisplatin - therapeutic use Crosstalk DNA, Mitochondrial - pharmacology Domains Drug dosages Drug resistance Drug Resistance, Neoplasm - genetics Female Homeostasis Humans Localization Metabolism Mitochondria Mitochondrial DNA Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Phosphorylation Proteasome inhibitors Proteins Transcription Transcription factors Tumor cells Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Ubiquitin Ubiquitin - metabolism
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