Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage

GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that mutant mice lacking the GCN2-binding domain suffer from growth retardation and postnatal lethality via GCN2-independ...

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Veröffentlicht in:	International journal of molecular sciences 2022-03, Vol.23 (6), p.3201
Hauptverfasser:	Liu, Jun, Kasai, Shuya, Tatara, Yota, Yamazaki, Hiromi, Mimura, Junsei, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Sato, Tsubasa, Ozaki, Taku, Tanji, Kunikazu, Wakabayashi, Koichi, Maeda, Hayato, Mizukami, Hiroki, Shinkai, Yasuhiro, Kumagai, Yoshito, Tomita, Hirofumi, Itoh, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Amino acid starvation Amino acids Animals Body weight Body weight loss Catabolism Cell cycle Embryogenesis Esterification Food intake Glucose Glycogen Glycogens Growth rate Kinases Lipid metabolism Lipids Lipoproteins (very low density) Liver Liver - metabolism Liver Glycogen - metabolism Mammals Mice Mice, Knockout Mitochondria Oxidation Peptide Elongation Factors - metabolism Protein Serine-Threonine Kinases Proteins Proteomics RNA-Binding Proteins - metabolism Rodents Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Starvation Tamoxifen Tamoxifen - adverse effects Tamoxifen - metabolism Trans-Activators - metabolism Weight Loss
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