The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Patients with AML harboring a constitutively active internal tandem duplication mutation (ITD ) in the FMS-like kinase tyrosine kinase (FLT3) receptor generally have a poor prognosis. Several tyrosine kinase/FLT3 inhibitors ha...

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Veröffentlicht in:	Cancers 2022-03, Vol.14 (6), p.1593
Hauptverfasser:	Lopez-Millan, Belen, Costales, Paula, Gutiérrez-Agüera, Francisco, Díaz de la Guardia, Rafael, Roca-Ho, Heleia, Vinyoles, Meritxell, Rubio-Gayarre, Alba, Safi, Rémi, Castaño, Julio, Romecín, Paola Alejandra, Ramírez-Orellana, Manuel, Anguita, Eduardo, Jeremias, Irmela, Zamora, Lurdes, Rodríguez-Manzaneque, Juan Carlos, Bueno, Clara, Morís, Francisco, Menendez, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Antibiotics Antibodies Apoptosis Bone marrow Cell cycle Cytotoxicity Enzyme inhibitors FDA approval Flow cytometry Hematopoietic stem cells Kinases Leukemia Mutation Patients Prognosis Protein-tyrosine kinase Research parks Stem cells Xenografts
Online-Zugang:	Volltext
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