t(4;12)(q12;p13) ETV6-rearranged AML without eosinophilia does not involve PDGFRA: relevance for imatinib insensitivity

Acute myeloid leukemia (AML) with t(4;12)(q12;p13) translocation is rare and often associated with an aggressive clinical course and poor prognosis. Previous reports based on fluorescence in situ hybridization (FISH) analysis have suggested that ETV6::PDGFRA fusions are present in these patients, de...

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Veröffentlicht in:	Blood advances 2022-02, Vol.6 (3), p.818-827
Hauptverfasser:	Mueller, Sarah B., Dal Cin, Paola, Le, Long P., Dias-Santagata, Dora, Lennerz, Jochen K., Iafrate, A. John, Marble, Hetal Desai, Brunner, Andrew M., Weinstock, Matthew J., Luskin, Marlise R., De Angelo, Daniel J., Stone, Richard M., Nardi, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Eosinophilia - genetics Humans Imatinib Mesylate - pharmacology Imatinib Mesylate - therapeutic use In Situ Hybridization, Fluorescence Leukemia, Myeloid, Acute - genetics Myeloid Neoplasia Receptor Protein-Tyrosine Kinases Retrospective Studies
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