Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong
Tuberculosis (TB) is an important public health problem. Studies indicated that TAP plays a key role in the presentation and transport of antigenic peptides during anti- M.tb infection. Given the important biological role of the TAP gene involved in anti- M.tb infection, a family-based case–control...
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| Veröffentlicht in: | Molecular genetics and genomics : MGG 2022-05, Vol.297 (3), p.779-790 |
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| creator | Luo, Fang Zou, PinAng Liao, Yinqian Luo, Jiaze Luo, Dan Hu, Kuan Zhang, KaiXuan Wang, BaoGuo |
| description | Tuberculosis (TB) is an important public health problem. Studies indicated that TAP plays a key role in the presentation and transport of antigenic peptides during anti-
M.tb
infection. Given the important biological role of the TAP gene involved in anti-
M.tb
infection, a family-based case–control study including 133 tuberculosis patients, 107 healthy household contacts, and 173 healthy controls was conducted to assess the association between TAP gene polymorphisms and TB susceptibility. The basic information of subjects and their blood samples were collected. Four SNPs including rs1135216, rs1057141, rs241447, and rs3819721 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). Our results suggested that BMI, residence, bedroom crowding, indoor humidity, fitness activities, history of smoking, and TB exposure history were associated with the occurrence of tuberculosis (
P
|
| doi_str_mv | 10.1007/s00438-022-01885-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8943507</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2668573231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-1e838b1e1ddca16d4f0c7965f0f98c4a20eef3e868b818c688ad12942b3de02b3</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSNERUvLH2CBLLFhE_AribNBGo1oi1SJLtq15Tg3GVeJHXyTovn3eJoyPBZsbEvnu-f66GTZW0Y_MkqrT0ipFCqnnOeUKVXk4kV2xkpW5bLk4uXxzYrT7DXiA6WsKnn1KjsVheAFr4qzDDeIwTozu-BJA_MPAE_uNrekBw9kCsN-DHHaORyRGN-SeWkg2mUI6JDggham2TVucPOeOE8MuTaebHfOAx7Gp2VYrZN2tRjft8H3F9lJZwaEN8_3eXZ_-eVue53ffLv6ut3c5FZSOecMlFANA9a21rCylR21VV0WHe1qZaXhFKAToErVKKZsqZRpGa8lb0QLNJ3n2efVd1qaEVoLfo5m0FN0o4l7HYzTfyve7XQfHrWqpSholQw-PBvE8H0BnPXoUuJhMB7CgpqXUlJaF9UBff8P-hCW6FO8RJWqqAQXLFF8pWwMiBG642cY1YdO9dqpTp3qp061SEPv_oxxHPlVYgLECmCSfA_x9-7_2P4EncCvdg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2668573231</pqid></control><display><type>article</type><title>Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Luo, Fang ; Zou, PinAng ; Liao, Yinqian ; Luo, Jiaze ; Luo, Dan ; Hu, Kuan ; Zhang, KaiXuan ; Wang, BaoGuo</creator><creatorcontrib>Luo, Fang ; Zou, PinAng ; Liao, Yinqian ; Luo, Jiaze ; Luo, Dan ; Hu, Kuan ; Zhang, KaiXuan ; Wang, BaoGuo</creatorcontrib><description>Tuberculosis (TB) is an important public health problem. Studies indicated that TAP plays a key role in the presentation and transport of antigenic peptides during anti-
M.tb
infection. Given the important biological role of the TAP gene involved in anti-
M.tb
infection, a family-based case–control study including 133 tuberculosis patients, 107 healthy household contacts, and 173 healthy controls was conducted to assess the association between TAP gene polymorphisms and TB susceptibility. The basic information of subjects and their blood samples were collected. Four SNPs including rs1135216, rs1057141, rs241447, and rs3819721 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). Our results suggested that BMI, residence, bedroom crowding, indoor humidity, fitness activities, history of smoking, and TB exposure history were associated with the occurrence of tuberculosis (
P
< 0.05). A significant association was observed between the TAP1 rs1135216 CT/CC genotype and increased TB risk, and the ORs were 2.56 (95% CI 1.31–4.99) and 6.73 (95% CI 1.33–34.02), respectively. TAP2 rs3819721 GG genotype carriers also showed an increased risk of TB when compared TB patients to healthy household contacts. Haplotype analysis revealed that the haplotype CT at rs1057141 and rs1135216 (OR = 11.34, 95% CI 1.49–86.56; OR = 7.45, 95% CI 1.43–38.76), as well as TA at rs241447 and rs3819721 (OR = 2.20, 95% CI 1.07–4.56) had a significantly increased risk of TB. The genetic risk scores (GRS) analysis of the four loci indicated that the risk of tuberculosis increased with increasing GRS scores in TB vs HHC (
P
trend
= 0.010) and in TB vs HC (
P
trend
= 0.001). In conclusion, our findings suggested that the SNPs of rs1135216 and rs3819721 were associated with TB susceptibility among the tuberculosis-prone families in the Chinese Han population and the risk of developing tuberculosis increases with the number of risk alleles, which could help identify high-risk groups in time and take scientific preventive measures. Further cohort studies with large samples are needed to validate the role of TAP gene variants on TB susceptibility.</description><identifier>ISSN: 1617-4615</identifier><identifier>EISSN: 1617-4623</identifier><identifier>DOI: 10.1007/s00438-022-01885-3</identifier><identifier>PMID: 35325275</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animal Genetics and Genomics ; Antigen presentation ; Biochemistry ; Biomedical and Life Sciences ; Case-Control Studies ; China - epidemiology ; Gene Frequency ; Gene polymorphism ; Genetic analysis ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Health care ; Human Genetics ; Humans ; Life Sciences ; Microbial Genetics and Genomics ; Original ; Original Article ; Plant Genetics and Genomics ; Polymerase chain reaction ; Polymorphism, Single Nucleotide - genetics ; Public health ; Restriction fragment length polymorphism ; Risk groups ; Single-nucleotide polymorphism ; Susceptibility ; Tuberculosis ; Tuberculosis - epidemiology ; Tuberculosis - genetics</subject><ispartof>Molecular genetics and genomics : MGG, 2022-05, Vol.297 (3), p.779-790</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-1e838b1e1ddca16d4f0c7965f0f98c4a20eef3e868b818c688ad12942b3de02b3</citedby><cites>FETCH-LOGICAL-c404t-1e838b1e1ddca16d4f0c7965f0f98c4a20eef3e868b818c688ad12942b3de02b3</cites><orcidid>0000-0001-8207-3665</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00438-022-01885-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00438-022-01885-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,778,782,883,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35325275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Fang</creatorcontrib><creatorcontrib>Zou, PinAng</creatorcontrib><creatorcontrib>Liao, Yinqian</creatorcontrib><creatorcontrib>Luo, Jiaze</creatorcontrib><creatorcontrib>Luo, Dan</creatorcontrib><creatorcontrib>Hu, Kuan</creatorcontrib><creatorcontrib>Zhang, KaiXuan</creatorcontrib><creatorcontrib>Wang, BaoGuo</creatorcontrib><title>Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong</title><title>Molecular genetics and genomics : MGG</title><addtitle>Mol Genet Genomics</addtitle><addtitle>Mol Genet Genomics</addtitle><description>Tuberculosis (TB) is an important public health problem. Studies indicated that TAP plays a key role in the presentation and transport of antigenic peptides during anti-
M.tb
infection. Given the important biological role of the TAP gene involved in anti-
M.tb
infection, a family-based case–control study including 133 tuberculosis patients, 107 healthy household contacts, and 173 healthy controls was conducted to assess the association between TAP gene polymorphisms and TB susceptibility. The basic information of subjects and their blood samples were collected. Four SNPs including rs1135216, rs1057141, rs241447, and rs3819721 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). Our results suggested that BMI, residence, bedroom crowding, indoor humidity, fitness activities, history of smoking, and TB exposure history were associated with the occurrence of tuberculosis (
P
< 0.05). A significant association was observed between the TAP1 rs1135216 CT/CC genotype and increased TB risk, and the ORs were 2.56 (95% CI 1.31–4.99) and 6.73 (95% CI 1.33–34.02), respectively. TAP2 rs3819721 GG genotype carriers also showed an increased risk of TB when compared TB patients to healthy household contacts. Haplotype analysis revealed that the haplotype CT at rs1057141 and rs1135216 (OR = 11.34, 95% CI 1.49–86.56; OR = 7.45, 95% CI 1.43–38.76), as well as TA at rs241447 and rs3819721 (OR = 2.20, 95% CI 1.07–4.56) had a significantly increased risk of TB. The genetic risk scores (GRS) analysis of the four loci indicated that the risk of tuberculosis increased with increasing GRS scores in TB vs HHC (
P
trend
= 0.010) and in TB vs HC (
P
trend
= 0.001). In conclusion, our findings suggested that the SNPs of rs1135216 and rs3819721 were associated with TB susceptibility among the tuberculosis-prone families in the Chinese Han population and the risk of developing tuberculosis increases with the number of risk alleles, which could help identify high-risk groups in time and take scientific preventive measures. Further cohort studies with large samples are needed to validate the role of TAP gene variants on TB susceptibility.</description><subject>Animal Genetics and Genomics</subject><subject>Antigen presentation</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic analysis</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Health care</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Original</subject><subject>Original Article</subject><subject>Plant Genetics and Genomics</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Public health</subject><subject>Restriction fragment length polymorphism</subject><subject>Risk groups</subject><subject>Single-nucleotide polymorphism</subject><subject>Susceptibility</subject><subject>Tuberculosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - genetics</subject><issn>1617-4615</issn><issn>1617-4623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhSNERUvLH2CBLLFhE_AribNBGo1oi1SJLtq15Tg3GVeJHXyTovn3eJoyPBZsbEvnu-f66GTZW0Y_MkqrT0ipFCqnnOeUKVXk4kV2xkpW5bLk4uXxzYrT7DXiA6WsKnn1KjsVheAFr4qzDDeIwTozu-BJA_MPAE_uNrekBw9kCsN-DHHaORyRGN-SeWkg2mUI6JDggham2TVucPOeOE8MuTaebHfOAx7Gp2VYrZN2tRjft8H3F9lJZwaEN8_3eXZ_-eVue53ffLv6ut3c5FZSOecMlFANA9a21rCylR21VV0WHe1qZaXhFKAToErVKKZsqZRpGa8lb0QLNJ3n2efVd1qaEVoLfo5m0FN0o4l7HYzTfyve7XQfHrWqpSholQw-PBvE8H0BnPXoUuJhMB7CgpqXUlJaF9UBff8P-hCW6FO8RJWqqAQXLFF8pWwMiBG642cY1YdO9dqpTp3qp061SEPv_oxxHPlVYgLECmCSfA_x9-7_2P4EncCvdg</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Luo, Fang</creator><creator>Zou, PinAng</creator><creator>Liao, Yinqian</creator><creator>Luo, Jiaze</creator><creator>Luo, Dan</creator><creator>Hu, Kuan</creator><creator>Zhang, KaiXuan</creator><creator>Wang, BaoGuo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8207-3665</orcidid></search><sort><creationdate>20220501</creationdate><title>Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong</title><author>Luo, Fang ; Zou, PinAng ; Liao, Yinqian ; Luo, Jiaze ; Luo, Dan ; Hu, Kuan ; Zhang, KaiXuan ; Wang, BaoGuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-1e838b1e1ddca16d4f0c7965f0f98c4a20eef3e868b818c688ad12942b3de02b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal Genetics and Genomics</topic><topic>Antigen presentation</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic analysis</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Health care</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Original</topic><topic>Original Article</topic><topic>Plant Genetics and Genomics</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Public health</topic><topic>Restriction fragment length polymorphism</topic><topic>Risk groups</topic><topic>Single-nucleotide polymorphism</topic><topic>Susceptibility</topic><topic>Tuberculosis</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Fang</creatorcontrib><creatorcontrib>Zou, PinAng</creatorcontrib><creatorcontrib>Liao, Yinqian</creatorcontrib><creatorcontrib>Luo, Jiaze</creatorcontrib><creatorcontrib>Luo, Dan</creatorcontrib><creatorcontrib>Hu, Kuan</creatorcontrib><creatorcontrib>Zhang, KaiXuan</creatorcontrib><creatorcontrib>Wang, BaoGuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular genetics and genomics : MGG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Fang</au><au>Zou, PinAng</au><au>Liao, Yinqian</au><au>Luo, Jiaze</au><au>Luo, Dan</au><au>Hu, Kuan</au><au>Zhang, KaiXuan</au><au>Wang, BaoGuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong</atitle><jtitle>Molecular genetics and genomics : MGG</jtitle><stitle>Mol Genet Genomics</stitle><addtitle>Mol Genet Genomics</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>297</volume><issue>3</issue><spage>779</spage><epage>790</epage><pages>779-790</pages><issn>1617-4615</issn><eissn>1617-4623</eissn><abstract>Tuberculosis (TB) is an important public health problem. Studies indicated that TAP plays a key role in the presentation and transport of antigenic peptides during anti-
M.tb
infection. Given the important biological role of the TAP gene involved in anti-
M.tb
infection, a family-based case–control study including 133 tuberculosis patients, 107 healthy household contacts, and 173 healthy controls was conducted to assess the association between TAP gene polymorphisms and TB susceptibility. The basic information of subjects and their blood samples were collected. Four SNPs including rs1135216, rs1057141, rs241447, and rs3819721 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). Our results suggested that BMI, residence, bedroom crowding, indoor humidity, fitness activities, history of smoking, and TB exposure history were associated with the occurrence of tuberculosis (
P
< 0.05). A significant association was observed between the TAP1 rs1135216 CT/CC genotype and increased TB risk, and the ORs were 2.56 (95% CI 1.31–4.99) and 6.73 (95% CI 1.33–34.02), respectively. TAP2 rs3819721 GG genotype carriers also showed an increased risk of TB when compared TB patients to healthy household contacts. Haplotype analysis revealed that the haplotype CT at rs1057141 and rs1135216 (OR = 11.34, 95% CI 1.49–86.56; OR = 7.45, 95% CI 1.43–38.76), as well as TA at rs241447 and rs3819721 (OR = 2.20, 95% CI 1.07–4.56) had a significantly increased risk of TB. The genetic risk scores (GRS) analysis of the four loci indicated that the risk of tuberculosis increased with increasing GRS scores in TB vs HHC (
P
trend
= 0.010) and in TB vs HC (
P
trend
= 0.001). In conclusion, our findings suggested that the SNPs of rs1135216 and rs3819721 were associated with TB susceptibility among the tuberculosis-prone families in the Chinese Han population and the risk of developing tuberculosis increases with the number of risk alleles, which could help identify high-risk groups in time and take scientific preventive measures. Further cohort studies with large samples are needed to validate the role of TAP gene variants on TB susceptibility.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35325275</pmid><doi>10.1007/s00438-022-01885-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8207-3665</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular genetics and genomics : MGG, 2022-05, Vol.297 (3), p.779-790 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animal Genetics and Genomics Antigen presentation Biochemistry Biomedical and Life Sciences Case-Control Studies China - epidemiology Gene Frequency Gene polymorphism Genetic analysis Genetic Predisposition to Disease Genotype Haplotypes Health care Human Genetics Humans Life Sciences Microbial Genetics and Genomics Original Original Article Plant Genetics and Genomics Polymerase chain reaction Polymorphism, Single Nucleotide - genetics Public health Restriction fragment length polymorphism Risk groups Single-nucleotide polymorphism Susceptibility Tuberculosis Tuberculosis - epidemiology Tuberculosis - genetics |
| title | Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong |
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