Role of medical comorbidity in the association between psychiatric disorders and mortality among patients with COVID-19
We examined whether excess chronic medical comorbidity mediated excess COVID-19 inpatient mortality among people with mental disorders in the early phase of the pandemic, a question with important implications for public health and clinical decision-making. Using records of 2599 COVID-19 hospitalize...
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| Veröffentlicht in: | Social Psychiatry and Psychiatric Epidemiology 2022-08, Vol.57 (8), p.1727-1730 |
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| creator | Martínez-Alés, Gonzalo Fernández-Jiménez, Eduardo Mediavilla, Roberto Quintana-Díaz, Manuel Louzao, Iker Cebolla, Susana Muñoz-Sanjosé, Ainoa Bayón, Carmen Susser, Ezra S. Bravo-Ortiz, María Fe |
| description | We examined whether excess chronic medical comorbidity mediated excess COVID-19 inpatient mortality among people with mental disorders in the early phase of the pandemic, a question with important implications for public health and clinical decision-making. Using records of 2599 COVID-19 hospitalized patients, we conducted a formal causal mediation analysis to estimate the extent to which chronic comorbidity mediates the association between mental disorders and COVID-19 mortality. The Odds Ratio (95% CI) for Natural Indirect Effect and Controlled Direct Effect were 1.07(1.02, 1.14) and 1.40 (1.00, 1.95), respectively, suggesting that a large proportion of excess COVID-19 mortality among people with mental disorders may be explained by factors other than comorbidity. |
| doi_str_mv | 10.1007/s00127-022-02271-5 |
| format | Article |
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Using records of 2599 COVID-19 hospitalized patients, we conducted a formal causal mediation analysis to estimate the extent to which chronic comorbidity mediates the association between mental disorders and COVID-19 mortality. The Odds Ratio (95% CI) for Natural Indirect Effect and Controlled Direct Effect were 1.07(1.02, 1.14) and 1.40 (1.00, 1.95), respectively, suggesting that a large proportion of excess COVID-19 mortality among people with mental disorders may be explained by factors other than comorbidity.</description><identifier>ISSN: 0933-7954</identifier><identifier>EISSN: 1433-9285</identifier><identifier>DOI: 10.1007/s00127-022-02271-5</identifier><identifier>PMID: 35322285</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Bipolar disorder ; Brief Report ; Comorbidity ; COVID-19 ; Decision making ; Epidemiology ; Hospital patients ; Humans ; Mediation ; Medicine ; Medicine & Public Health ; Mental disorders ; Mental Disorders - epidemiology ; Mental Disorders - psychology ; Mental illness ; Mentally ill ; Mortality ; Pandemics ; Patient outcomes ; Psychiatry ; Public health ; SARS-CoV-2</subject><ispartof>Social Psychiatry and Psychiatric Epidemiology, 2022-08, Vol.57 (8), p.1727-1730</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-5ccc31d250a202d9230ba62c7c257574080372cc38235e0404b8bcbbc7d826d53</citedby><cites>FETCH-LOGICAL-c541t-5ccc31d250a202d9230ba62c7c257574080372cc38235e0404b8bcbbc7d826d53</cites><orcidid>0000-0002-1902-4067</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00127-022-02271-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00127-022-02271-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,778,782,883,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35322285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martínez-Alés, Gonzalo</creatorcontrib><creatorcontrib>Fernández-Jiménez, Eduardo</creatorcontrib><creatorcontrib>Mediavilla, Roberto</creatorcontrib><creatorcontrib>Quintana-Díaz, Manuel</creatorcontrib><creatorcontrib>Louzao, Iker</creatorcontrib><creatorcontrib>Cebolla, Susana</creatorcontrib><creatorcontrib>Muñoz-Sanjosé, Ainoa</creatorcontrib><creatorcontrib>Bayón, Carmen</creatorcontrib><creatorcontrib>Susser, Ezra S.</creatorcontrib><creatorcontrib>Bravo-Ortiz, María Fe</creatorcontrib><creatorcontrib>COVID@HULP group of investigators</creatorcontrib><creatorcontrib>on behalf of the COVID@HULP group of investigators</creatorcontrib><title>Role of medical comorbidity in the association between psychiatric disorders and mortality among patients with COVID-19</title><title>Social Psychiatry and Psychiatric Epidemiology</title><addtitle>Soc Psychiatry Psychiatr Epidemiol</addtitle><addtitle>Soc Psychiatry Psychiatr Epidemiol</addtitle><description>We examined whether excess chronic medical comorbidity mediated excess COVID-19 inpatient mortality among people with mental disorders in the early phase of the pandemic, a question with important implications for public health and clinical decision-making. Using records of 2599 COVID-19 hospitalized patients, we conducted a formal causal mediation analysis to estimate the extent to which chronic comorbidity mediates the association between mental disorders and COVID-19 mortality. The Odds Ratio (95% CI) for Natural Indirect Effect and Controlled Direct Effect were 1.07(1.02, 1.14) and 1.40 (1.00, 1.95), respectively, suggesting that a large proportion of excess COVID-19 mortality among people with mental disorders may be explained by factors other than comorbidity.</description><subject>Analysis</subject><subject>Bipolar disorder</subject><subject>Brief Report</subject><subject>Comorbidity</subject><subject>COVID-19</subject><subject>Decision making</subject><subject>Epidemiology</subject><subject>Hospital patients</subject><subject>Humans</subject><subject>Mediation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - psychology</subject><subject>Mental illness</subject><subject>Mentally ill</subject><subject>Mortality</subject><subject>Pandemics</subject><subject>Patient outcomes</subject><subject>Psychiatry</subject><subject>Public health</subject><subject>SARS-CoV-2</subject><issn>0933-7954</issn><issn>1433-9285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kl9rFDEUxYModq1-AR8k4IsvU2-SyWTmRSjrv0KhIOpryCTZ3ZSZZE1mu-y3945bWysiISTc_M5JbjiEvGRwxgDU2wLAuKqA83kqVslHZMFqIaqOt_IxWUCHe9XJ-oQ8K-UaAESnxFNyIqTgHJkF2X9Jg6dpRUfvgjUDtWlMuQ8uTAcaIp02nppSkg1mCinS3k977yPdloPdYC0HS10oKTufCzXRUZRPZpjlZkxxTbco9HEqdB-mDV1efb94X7HuOXmyMkPxL27XU_Lt44evy8_V5dWni-X5ZWVlzaZKWmsFc1yC4cBdxwX0puFWWS6VVDW0IBRHpuVCeqih7tve9r1VruWNk-KUvDv6bnc9tmjxJdkMepvDaPJBJxP0w5MYNnqdbnTb1VzJDg3e3Brk9GPny6THUKwfBhN92hXNm5q3CCtA9PVf6HXa5YjtIdVB2zBo5D21NoPXIa4S3mtnU32ukOC1Egyps39QOJwfg03RrwLWHwj4UWBzKiX71V2PDPQcF32Mi8ao6F9x0fNbXv35O3eS3_lAQByBgkdx7fN9S_-x_QkxL8oy</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Martínez-Alés, Gonzalo</creator><creator>Fernández-Jiménez, Eduardo</creator><creator>Mediavilla, Roberto</creator><creator>Quintana-Díaz, Manuel</creator><creator>Louzao, Iker</creator><creator>Cebolla, Susana</creator><creator>Muñoz-Sanjosé, Ainoa</creator><creator>Bayón, Carmen</creator><creator>Susser, Ezra S.</creator><creator>Bravo-Ortiz, María Fe</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1902-4067</orcidid></search><sort><creationdate>20220801</creationdate><title>Role of medical comorbidity in the association between psychiatric disorders and mortality among patients with COVID-19</title><author>Martínez-Alés, Gonzalo ; Fernández-Jiménez, Eduardo ; Mediavilla, Roberto ; Quintana-Díaz, Manuel ; Louzao, Iker ; Cebolla, Susana ; Muñoz-Sanjosé, Ainoa ; Bayón, Carmen ; Susser, Ezra S. ; Bravo-Ortiz, María Fe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-5ccc31d250a202d9230ba62c7c257574080372cc38235e0404b8bcbbc7d826d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Bipolar disorder</topic><topic>Brief Report</topic><topic>Comorbidity</topic><topic>COVID-19</topic><topic>Decision making</topic><topic>Epidemiology</topic><topic>Hospital patients</topic><topic>Humans</topic><topic>Mediation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Mental Disorders - 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| ispartof | Social Psychiatry and Psychiatric Epidemiology, 2022-08, Vol.57 (8), p.1727-1730 |
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| subjects | Analysis Bipolar disorder Brief Report Comorbidity COVID-19 Decision making Epidemiology Hospital patients Humans Mediation Medicine Medicine & Public Health Mental disorders Mental Disorders - epidemiology Mental Disorders - psychology Mental illness Mentally ill Mortality Pandemics Patient outcomes Psychiatry Public health SARS-CoV-2 |
| title | Role of medical comorbidity in the association between psychiatric disorders and mortality among patients with COVID-19 |
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