Slip-Ups in the Diagnosis of Cardiac Amyloidosis: A Case Fatality in Point
This case report illustrates a tragic example of a "missed diagnosis" of amyloid light-chain (AL) amyloidosis with cardiac involvement that led to progressive heart failure and the ultimate death of the patient. It had a rather atypical presentation in terms of cardiac imaging, although th...
Gespeichert in:
| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-02, Vol.14 (2), p.e22458 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | e22458 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 14 |
| creator | Hobocan, Marissa Shaik, Ayesha Saad, Amjad Dasgupta, Oisharya Jaiswal, Abhishek |
| description | This case report illustrates a tragic example of a "missed diagnosis" of amyloid light-chain (AL) amyloidosis with cardiac involvement that led to progressive heart failure and the ultimate death of the patient. It had a rather atypical presentation in terms of cardiac imaging, although there were certain highly suspicious clinical features, cardiac and otherwise. It also illustrates the importance of selecting the most appropriate assays to establish (or rule out) the presence of monoclonal immunoglobulin consistent with AL amyloidosis, which has a poor clinical prognosis, as unfortunately demonstrated in this case. |
| doi_str_mv | 10.7759/cureus.22458 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2645759719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c266t-613c951d2b5411ed524ea25deb8f984465be6d30373473349b214fa0580d6c673</originalsourceid><addsrcrecordid>eNpVkM1Lw0AQxRdRbKm9eZaAV1P3ezcehFKtHxQUtOdlk2zaLWm27iZC_3sTW0s9zTDz5s3jB8AlgiMhWHKbNd40YYQxZfIE9DHiMpZI0tOjvgeGIawghAgKDAU8Bz3CCGUCkT54_SjtJp5vQmSrqF6a6MHqReWCDZEroon2udVZNF5vS2fzbnwXjdtxMNFU17q09bY7fHe2qi_AWaHLYIb7OgDz6ePn5DmevT29TMazOMOc1zFHJEsYynHKKEImZ5gajVluUlkkklLOUsNzAokgVBBCkxQjWmjIJMx5xgUZgPud76ZJ1ybPTFV7XaqNt2vtt8ppq_5vKrtUC_etZEIxlp3B9d7Au6_GhFqtXOOrNrPCvOXCEoGSVnWzU2XeheBNcfiAoOrgqx189Qu_lV8dpzqI_1CTH_v_f4s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2645759719</pqid></control><display><type>article</type><title>Slip-Ups in the Diagnosis of Cardiac Amyloidosis: A Case Fatality in Point</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Hobocan, Marissa ; Shaik, Ayesha ; Saad, Amjad ; Dasgupta, Oisharya ; Jaiswal, Abhishek</creator><creatorcontrib>Hobocan, Marissa ; Shaik, Ayesha ; Saad, Amjad ; Dasgupta, Oisharya ; Jaiswal, Abhishek</creatorcontrib><description>This case report illustrates a tragic example of a "missed diagnosis" of amyloid light-chain (AL) amyloidosis with cardiac involvement that led to progressive heart failure and the ultimate death of the patient. It had a rather atypical presentation in terms of cardiac imaging, although there were certain highly suspicious clinical features, cardiac and otherwise. It also illustrates the importance of selecting the most appropriate assays to establish (or rule out) the presence of monoclonal immunoglobulin consistent with AL amyloidosis, which has a poor clinical prognosis, as unfortunately demonstrated in this case.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.22458</identifier><identifier>PMID: 35345713</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Amyloidosis ; Anemia ; Autopsies ; Biopsy ; Bone marrow ; Cardiac arrhythmia ; Cardiology ; Case reports ; Coronaviruses ; COVID-19 ; Dyspnea ; Electrocardiography ; Fatalities ; Heart failure ; Hematology ; Hospitalization ; Internal Medicine ; Light ; Mammography ; Medical diagnosis ; Medical prognosis ; Proteins ; Ultrasonic imaging ; Urine</subject><ispartof>Curēus (Palo Alto, CA), 2022-02, Vol.14 (2), p.e22458</ispartof><rights>Copyright © 2022, Hobocan et al.</rights><rights>Copyright © 2022, Hobocan et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Hobocan et al. 2022 Hobocan et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c266t-613c951d2b5411ed524ea25deb8f984465be6d30373473349b214fa0580d6c673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942287/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942287/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35345713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hobocan, Marissa</creatorcontrib><creatorcontrib>Shaik, Ayesha</creatorcontrib><creatorcontrib>Saad, Amjad</creatorcontrib><creatorcontrib>Dasgupta, Oisharya</creatorcontrib><creatorcontrib>Jaiswal, Abhishek</creatorcontrib><title>Slip-Ups in the Diagnosis of Cardiac Amyloidosis: A Case Fatality in Point</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>This case report illustrates a tragic example of a "missed diagnosis" of amyloid light-chain (AL) amyloidosis with cardiac involvement that led to progressive heart failure and the ultimate death of the patient. It had a rather atypical presentation in terms of cardiac imaging, although there were certain highly suspicious clinical features, cardiac and otherwise. It also illustrates the importance of selecting the most appropriate assays to establish (or rule out) the presence of monoclonal immunoglobulin consistent with AL amyloidosis, which has a poor clinical prognosis, as unfortunately demonstrated in this case.</description><subject>Amyloidosis</subject><subject>Anemia</subject><subject>Autopsies</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Case reports</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Dyspnea</subject><subject>Electrocardiography</subject><subject>Fatalities</subject><subject>Heart failure</subject><subject>Hematology</subject><subject>Hospitalization</subject><subject>Internal Medicine</subject><subject>Light</subject><subject>Mammography</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Proteins</subject><subject>Ultrasonic imaging</subject><subject>Urine</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkM1Lw0AQxRdRbKm9eZaAV1P3ezcehFKtHxQUtOdlk2zaLWm27iZC_3sTW0s9zTDz5s3jB8AlgiMhWHKbNd40YYQxZfIE9DHiMpZI0tOjvgeGIawghAgKDAU8Bz3CCGUCkT54_SjtJp5vQmSrqF6a6MHqReWCDZEroon2udVZNF5vS2fzbnwXjdtxMNFU17q09bY7fHe2qi_AWaHLYIb7OgDz6ePn5DmevT29TMazOMOc1zFHJEsYynHKKEImZ5gajVluUlkkklLOUsNzAokgVBBCkxQjWmjIJMx5xgUZgPud76ZJ1ybPTFV7XaqNt2vtt8ppq_5vKrtUC_etZEIxlp3B9d7Au6_GhFqtXOOrNrPCvOXCEoGSVnWzU2XeheBNcfiAoOrgqx189Qu_lV8dpzqI_1CTH_v_f4s</recordid><startdate>20220221</startdate><enddate>20220221</enddate><creator>Hobocan, Marissa</creator><creator>Shaik, Ayesha</creator><creator>Saad, Amjad</creator><creator>Dasgupta, Oisharya</creator><creator>Jaiswal, Abhishek</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20220221</creationdate><title>Slip-Ups in the Diagnosis of Cardiac Amyloidosis: A Case Fatality in Point</title><author>Hobocan, Marissa ; Shaik, Ayesha ; Saad, Amjad ; Dasgupta, Oisharya ; Jaiswal, Abhishek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c266t-613c951d2b5411ed524ea25deb8f984465be6d30373473349b214fa0580d6c673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amyloidosis</topic><topic>Anemia</topic><topic>Autopsies</topic><topic>Biopsy</topic><topic>Bone marrow</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Case reports</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Dyspnea</topic><topic>Electrocardiography</topic><topic>Fatalities</topic><topic>Heart failure</topic><topic>Hematology</topic><topic>Hospitalization</topic><topic>Internal Medicine</topic><topic>Light</topic><topic>Mammography</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Proteins</topic><topic>Ultrasonic imaging</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hobocan, Marissa</creatorcontrib><creatorcontrib>Shaik, Ayesha</creatorcontrib><creatorcontrib>Saad, Amjad</creatorcontrib><creatorcontrib>Dasgupta, Oisharya</creatorcontrib><creatorcontrib>Jaiswal, Abhishek</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hobocan, Marissa</au><au>Shaik, Ayesha</au><au>Saad, Amjad</au><au>Dasgupta, Oisharya</au><au>Jaiswal, Abhishek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Slip-Ups in the Diagnosis of Cardiac Amyloidosis: A Case Fatality in Point</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2022-02-21</date><risdate>2022</risdate><volume>14</volume><issue>2</issue><spage>e22458</spage><pages>e22458-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>This case report illustrates a tragic example of a "missed diagnosis" of amyloid light-chain (AL) amyloidosis with cardiac involvement that led to progressive heart failure and the ultimate death of the patient. It had a rather atypical presentation in terms of cardiac imaging, although there were certain highly suspicious clinical features, cardiac and otherwise. It also illustrates the importance of selecting the most appropriate assays to establish (or rule out) the presence of monoclonal immunoglobulin consistent with AL amyloidosis, which has a poor clinical prognosis, as unfortunately demonstrated in this case.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>35345713</pmid><doi>10.7759/cureus.22458</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2022-02, Vol.14 (2), p.e22458 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942287 |
| source | PubMed Central Open Access; PubMed Central |
| subjects | Amyloidosis Anemia Autopsies Biopsy Bone marrow Cardiac arrhythmia Cardiology Case reports Coronaviruses COVID-19 Dyspnea Electrocardiography Fatalities Heart failure Hematology Hospitalization Internal Medicine Light Mammography Medical diagnosis Medical prognosis Proteins Ultrasonic imaging Urine |
| title | Slip-Ups in the Diagnosis of Cardiac Amyloidosis: A Case Fatality in Point |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T11%3A10%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Slip-Ups%20in%20the%20Diagnosis%20of%20Cardiac%20Amyloidosis:%20A%20Case%20Fatality%20in%20Point&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Hobocan,%20Marissa&rft.date=2022-02-21&rft.volume=14&rft.issue=2&rft.spage=e22458&rft.pages=e22458-&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.22458&rft_dat=%3Cproquest_pubme%3E2645759719%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2645759719&rft_id=info:pmid/35345713&rfr_iscdi=true |