Eukaryotic TYW1 Is a Radical SAM Flavoenzyme

TYW1 is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the condensation of pyruvate and N-methylguanosine-containing tRNAPhe, forming 4-demethylwyosine-containing tRNAPhe. Homologues of TYW1 are found in both archaea and eukarya; archaeal homologues consist of a single domain, while e...

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Veröffentlicht in:	Biochemistry (Easton) 2021-07, Vol.60 (27), p.2179-2185
Hauptverfasser:	Young, Anthony P., Bandarian, Vahe
Format:	Artikel
Sprache:	eng
Schlagworte:	Flavin Mononucleotide - metabolism NADP - metabolism Oxidoreductases - metabolism S-Adenosylmethionine - metabolism Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism
Online-Zugang:	Volltext
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