The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer

Selenium (Se) is incorporated into the body via the selenocysteine (Sec) biosynthesis pathway, which is critical in the synthesis of selenoproteins, such as glutathione peroxidases and thioredoxin reductases. Selenoproteins, which play a key role in several biological processes, including ferroptosi...

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Veröffentlicht in:	Journal of cellular biochemistry 2022-03, Vol.123 (3), p.532-542
Hauptverfasser:	Kalimuthu, Kalishwaralal, Keerthana, Chenicheri K., Mohan, Manikandan, Arivalagan, Jaison, Christyraj, Johnson Retnaraj Samuel Selvan, Firer, Michael A., Choudry, Mohammad Haroon Asif, Anto, Ruby John, Lee, Yong J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Biological activity Biomarkers Biosynthesis Cancer Cancer therapies cancer therapy Carrier Proteins - metabolism Drug resistance Endoplasmic reticulum Epigenetics Ferroptosis Glutathione glutathione peroxidase‐4 Humans Metabolic Networks and Pathways Metabolic pathways Metabolism Molecular modelling Neoplasms - drug therapy Peptides Proteins Reductases Selenium Selenium - metabolism Selenium - therapeutic use Selenocysteine selenocysteine insertion sequence binding protein 2 Selenoproteins Selenoproteins - chemistry Selenoproteins - metabolism Therapeutic applications Therapeutic targets Thioredoxin thioredoxin reductase 1 Thioredoxin-Disulfide Reductase - metabolism
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