Spermidine Regulates Mitochondrial Function by Enhancing eIF5A Hypusination and Contributes to Reactive Oxygen Species Production and Ganoderic Acid Biosynthesis in Ganoderma lucidum

Spermidine, a kind of polycation and one important member of the polyamine family, is essential for survival in many kinds of organisms and participates in the regulation of cell growth and metabolism. To explore the mechanism by which spermidine regulates ganoderic acid (GA) biosynthesis in Ganoder...

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Veröffentlicht in:	Applied and environmental microbiology 2022-03, Vol.88 (6), p.e0203721-e0203721
Hauptverfasser:	Han, Xiaofei, Shangguan, Jiaolei, Wang, Zi, Li, Yu, Fan, Junpei, Ren, Ang, Zhao, Mingwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Cell growth Eukaryotic Translation Initiation Factor 5A Ganoderic acid Ganoderma lucidum Genetics and Molecular Biology Homeostasis Hydroxylase Initiation factor eIF-5A Metabolites Mitochondria Mitochondria - metabolism Mushrooms Oxygen Peptide Initiation Factors Polyamines Polyelectrolytes Reactive oxygen species Reactive Oxygen Species - metabolism Reishi - metabolism RNA-Binding Proteins Secondary metabolites Spermidine Spermidine - metabolism Spermidine synthase Triterpenes
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