Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic
Background and objectives In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In consequence, pulmonary infections due to other respiratory pathogens also decreased. Here, we evaluated the number...
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| Veröffentlicht in: | Journal of neurology 2022-07, Vol.269 (7), p.3389-3399 |
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| creator | Völk, Stefanie Pfirrmann, Markus Koedel, Uwe Pfister, Hans-Walter Lang, Thomas Scheibe, Franziska Salih, Farid Herzig-Nichtweiss, Julia Zimmermann, Julian Alonso, Angelika Wittstock, Matthias Totzeck, Andreas Schramm, Patrick Schirotzek, Ingo Onur, Oezguer A. Pelz, Johann Otto Ottomeyer, Caroline Luger, Sebastian Barlinn, Kristian Binder, Tobias Wöbker, Gabriele Reimann, Gernot Urbanek, Christian Heckelmann, Jan Lochner, Piergiorgio Berghoff, Martin Schönenberger, Silvia Neumann, Bernhard Niesen, Wolf-Dirk Dohmen, Christian Huttner, Hagen B. Günther, Albrecht Klein, Matthias |
| description | Background and objectives
In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In consequence, pulmonary infections due to other respiratory pathogens also decreased. Here, we evaluated the number of bacterial and viral meningitis and encephalitis cases during the coronavirus disease 2019 (COVID-19) pandemic.
Methods
In a multicentre retrospective analysis of data from January 2016 until December 2020, numbers of patients diagnosed with bacterial meningitis and other types of CNS infections (such as viral meningitis and encephalitis) at 26 German hospitals were studied. Furthermore, the number of common meningitis-preceding ear-nose-throat infections (sinusitis, mastoiditis and otitis media) was evaluated.
Results
Compared to the previous years, the total number of patients diagnosed with pneumococcal meningitis was reduced (
n
= 64 patients/year in 2020 vs.
n
= 87 to 120 patients/year between 2016 and 2019, all
p
|
| doi_str_mv | 10.1007/s00415-022-11034-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8938731</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2679455325</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-e98adaa20697229b358957215da4e15b780812a198fe30ee9a7da0e06936ca1e3</originalsourceid><addsrcrecordid>eNp9kU9P3DAQxS1UVLbAF-CALPXSS4rHfzb2pVK121IkJC7A1XKSWdYocYKdsOq3r5cF2nLgZNnvN29m_Ag5AfYVGCvPEmMSVME4LwCYkMVmj8xAinyVynwgs_zGCiWUPCCfUrpnjOksfCQHQgmYC61npFpi3fqA1Ac6rpGGqasw0n5FBzd6DGOiGz-uaYfBhzs_-rQlzzF2LtB1nwY_ujbRZopZfnJYXN1eLAsw2SA02Pn6iOyvMoPHz-chufn543rxq7i8Or9YfL8salnKsUCjXeMcZ3NTcm4qobRRJQfVOImgqlIzDdyB0SsUDNG4snEMMy7mtQMUh-TbzneYqg6bOg8fXWuH6DsXf9veefu_Evza3vWPVhuhSwHZ4MuzQewfJkyj7XyqsW1dwH5Kls8lF6A16Ix-foPe91MMeb1MlUYqJbjKFN9RdexTirh6HQaY3UZodxHaHKF9itBuctHpv2u8lrxklgGxA9Kw_XSMf3u_Y_sH55qnQQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2679455325</pqid></control><display><type>article</type><title>Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic</title><source>SpringerLink Journals</source><creator>Völk, Stefanie ; Pfirrmann, Markus ; Koedel, Uwe ; Pfister, Hans-Walter ; Lang, Thomas ; Scheibe, Franziska ; Salih, Farid ; Herzig-Nichtweiss, Julia ; Zimmermann, Julian ; Alonso, Angelika ; Wittstock, Matthias ; Totzeck, Andreas ; Schramm, Patrick ; Schirotzek, Ingo ; Onur, Oezguer A. ; Pelz, Johann Otto ; Ottomeyer, Caroline ; Luger, Sebastian ; Barlinn, Kristian ; Binder, Tobias ; Wöbker, Gabriele ; Reimann, Gernot ; Urbanek, Christian ; Heckelmann, Jan ; Lochner, Piergiorgio ; Berghoff, Martin ; Schönenberger, Silvia ; Neumann, Bernhard ; Niesen, Wolf-Dirk ; Dohmen, Christian ; Huttner, Hagen B. ; Günther, Albrecht ; Klein, Matthias</creator><creatorcontrib>Völk, Stefanie ; Pfirrmann, Markus ; Koedel, Uwe ; Pfister, Hans-Walter ; Lang, Thomas ; Scheibe, Franziska ; Salih, Farid ; Herzig-Nichtweiss, Julia ; Zimmermann, Julian ; Alonso, Angelika ; Wittstock, Matthias ; Totzeck, Andreas ; Schramm, Patrick ; Schirotzek, Ingo ; Onur, Oezguer A. ; Pelz, Johann Otto ; Ottomeyer, Caroline ; Luger, Sebastian ; Barlinn, Kristian ; Binder, Tobias ; Wöbker, Gabriele ; Reimann, Gernot ; Urbanek, Christian ; Heckelmann, Jan ; Lochner, Piergiorgio ; Berghoff, Martin ; Schönenberger, Silvia ; Neumann, Bernhard ; Niesen, Wolf-Dirk ; Dohmen, Christian ; Huttner, Hagen B. ; Günther, Albrecht ; Klein, Matthias</creatorcontrib><description>Background and objectives
In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In consequence, pulmonary infections due to other respiratory pathogens also decreased. Here, we evaluated the number of bacterial and viral meningitis and encephalitis cases during the coronavirus disease 2019 (COVID-19) pandemic.
Methods
In a multicentre retrospective analysis of data from January 2016 until December 2020, numbers of patients diagnosed with bacterial meningitis and other types of CNS infections (such as viral meningitis and encephalitis) at 26 German hospitals were studied. Furthermore, the number of common meningitis-preceding ear-nose-throat infections (sinusitis, mastoiditis and otitis media) was evaluated.
Results
Compared to the previous years, the total number of patients diagnosed with pneumococcal meningitis was reduced (
n
= 64 patients/year in 2020 vs.
n
= 87 to 120 patients/year between 2016 and 2019, all
p
< 0.05). Additionally, the total number of patients diagnosed with otolaryngological infections was significantly lower (
n
= 1181 patients/year in 2020 vs.
n
= 1525 to 1754 patients/year between 2016 and 2019, all
p
< 0.001). We also observed a decline in viral meningitis and especially enterovirus meningitis (
n
= 25 patients/year in 2020 vs.
n
= 97 to 181 patients/year between 2016 and 2019, all
p
< 0.001).
Discussion
This multicentre retrospective analysis demonstrates a decline in the number of patients treated for viral and pneumococcal meningitis as well as otolaryngological infections in 2020 compared to previous years. Since the latter often precedes pneumococcal meningitis, this may point to the significance of the direct spread of pneumococci from an otolaryngological focus such as mastoiditis to the brain as one important pathophysiological route in the development of pneumococcal meningitis.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-022-11034-w</identifier><identifier>PMID: 35316388</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aseptic meningitis ; Coronaviruses ; COVID-19 ; Encephalitis ; Hospitals ; Hygiene ; Infections ; Mastoiditis ; Medicine ; Medicine & Public Health ; Meningitis ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Otitis media ; Pandemics ; Patients ; Respiratory diseases ; Severe acute respiratory syndrome coronavirus 2 ; Sinusitis ; Streptococcus infections</subject><ispartof>Journal of neurology, 2022-07, Vol.269 (7), p.3389-3399</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e98adaa20697229b358957215da4e15b780812a198fe30ee9a7da0e06936ca1e3</citedby><cites>FETCH-LOGICAL-c474t-e98adaa20697229b358957215da4e15b780812a198fe30ee9a7da0e06936ca1e3</cites><orcidid>0000-0001-6929-3831</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-022-11034-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-022-11034-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35316388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Völk, Stefanie</creatorcontrib><creatorcontrib>Pfirrmann, Markus</creatorcontrib><creatorcontrib>Koedel, Uwe</creatorcontrib><creatorcontrib>Pfister, Hans-Walter</creatorcontrib><creatorcontrib>Lang, Thomas</creatorcontrib><creatorcontrib>Scheibe, Franziska</creatorcontrib><creatorcontrib>Salih, Farid</creatorcontrib><creatorcontrib>Herzig-Nichtweiss, Julia</creatorcontrib><creatorcontrib>Zimmermann, Julian</creatorcontrib><creatorcontrib>Alonso, Angelika</creatorcontrib><creatorcontrib>Wittstock, Matthias</creatorcontrib><creatorcontrib>Totzeck, Andreas</creatorcontrib><creatorcontrib>Schramm, Patrick</creatorcontrib><creatorcontrib>Schirotzek, Ingo</creatorcontrib><creatorcontrib>Onur, Oezguer A.</creatorcontrib><creatorcontrib>Pelz, Johann Otto</creatorcontrib><creatorcontrib>Ottomeyer, Caroline</creatorcontrib><creatorcontrib>Luger, Sebastian</creatorcontrib><creatorcontrib>Barlinn, Kristian</creatorcontrib><creatorcontrib>Binder, Tobias</creatorcontrib><creatorcontrib>Wöbker, Gabriele</creatorcontrib><creatorcontrib>Reimann, Gernot</creatorcontrib><creatorcontrib>Urbanek, Christian</creatorcontrib><creatorcontrib>Heckelmann, Jan</creatorcontrib><creatorcontrib>Lochner, Piergiorgio</creatorcontrib><creatorcontrib>Berghoff, Martin</creatorcontrib><creatorcontrib>Schönenberger, Silvia</creatorcontrib><creatorcontrib>Neumann, Bernhard</creatorcontrib><creatorcontrib>Niesen, Wolf-Dirk</creatorcontrib><creatorcontrib>Dohmen, Christian</creatorcontrib><creatorcontrib>Huttner, Hagen B.</creatorcontrib><creatorcontrib>Günther, Albrecht</creatorcontrib><creatorcontrib>Klein, Matthias</creatorcontrib><title>Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background and objectives
In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In consequence, pulmonary infections due to other respiratory pathogens also decreased. Here, we evaluated the number of bacterial and viral meningitis and encephalitis cases during the coronavirus disease 2019 (COVID-19) pandemic.
Methods
In a multicentre retrospective analysis of data from January 2016 until December 2020, numbers of patients diagnosed with bacterial meningitis and other types of CNS infections (such as viral meningitis and encephalitis) at 26 German hospitals were studied. Furthermore, the number of common meningitis-preceding ear-nose-throat infections (sinusitis, mastoiditis and otitis media) was evaluated.
Results
Compared to the previous years, the total number of patients diagnosed with pneumococcal meningitis was reduced (
n
= 64 patients/year in 2020 vs.
n
= 87 to 120 patients/year between 2016 and 2019, all
p
< 0.05). Additionally, the total number of patients diagnosed with otolaryngological infections was significantly lower (
n
= 1181 patients/year in 2020 vs.
n
= 1525 to 1754 patients/year between 2016 and 2019, all
p
< 0.001). We also observed a decline in viral meningitis and especially enterovirus meningitis (
n
= 25 patients/year in 2020 vs.
n
= 97 to 181 patients/year between 2016 and 2019, all
p
< 0.001).
Discussion
This multicentre retrospective analysis demonstrates a decline in the number of patients treated for viral and pneumococcal meningitis as well as otolaryngological infections in 2020 compared to previous years. Since the latter often precedes pneumococcal meningitis, this may point to the significance of the direct spread of pneumococci from an otolaryngological focus such as mastoiditis to the brain as one important pathophysiological route in the development of pneumococcal meningitis.</description><subject>Aseptic meningitis</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Encephalitis</subject><subject>Hospitals</subject><subject>Hygiene</subject><subject>Infections</subject><subject>Mastoiditis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningitis</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Otitis media</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Respiratory diseases</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sinusitis</subject><subject>Streptococcus infections</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9P3DAQxS1UVLbAF-CALPXSS4rHfzb2pVK121IkJC7A1XKSWdYocYKdsOq3r5cF2nLgZNnvN29m_Ag5AfYVGCvPEmMSVME4LwCYkMVmj8xAinyVynwgs_zGCiWUPCCfUrpnjOksfCQHQgmYC61npFpi3fqA1Ac6rpGGqasw0n5FBzd6DGOiGz-uaYfBhzs_-rQlzzF2LtB1nwY_ujbRZopZfnJYXN1eLAsw2SA02Pn6iOyvMoPHz-chufn543rxq7i8Or9YfL8salnKsUCjXeMcZ3NTcm4qobRRJQfVOImgqlIzDdyB0SsUDNG4snEMMy7mtQMUh-TbzneYqg6bOg8fXWuH6DsXf9veefu_Evza3vWPVhuhSwHZ4MuzQewfJkyj7XyqsW1dwH5Kls8lF6A16Ix-foPe91MMeb1MlUYqJbjKFN9RdexTirh6HQaY3UZodxHaHKF9itBuctHpv2u8lrxklgGxA9Kw_XSMf3u_Y_sH55qnQQ</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Völk, Stefanie</creator><creator>Pfirrmann, Markus</creator><creator>Koedel, Uwe</creator><creator>Pfister, Hans-Walter</creator><creator>Lang, Thomas</creator><creator>Scheibe, Franziska</creator><creator>Salih, Farid</creator><creator>Herzig-Nichtweiss, Julia</creator><creator>Zimmermann, Julian</creator><creator>Alonso, Angelika</creator><creator>Wittstock, Matthias</creator><creator>Totzeck, Andreas</creator><creator>Schramm, Patrick</creator><creator>Schirotzek, Ingo</creator><creator>Onur, Oezguer A.</creator><creator>Pelz, Johann Otto</creator><creator>Ottomeyer, Caroline</creator><creator>Luger, Sebastian</creator><creator>Barlinn, Kristian</creator><creator>Binder, Tobias</creator><creator>Wöbker, Gabriele</creator><creator>Reimann, Gernot</creator><creator>Urbanek, Christian</creator><creator>Heckelmann, Jan</creator><creator>Lochner, Piergiorgio</creator><creator>Berghoff, Martin</creator><creator>Schönenberger, Silvia</creator><creator>Neumann, Bernhard</creator><creator>Niesen, Wolf-Dirk</creator><creator>Dohmen, Christian</creator><creator>Huttner, Hagen B.</creator><creator>Günther, Albrecht</creator><creator>Klein, Matthias</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6929-3831</orcidid></search><sort><creationdate>20220701</creationdate><title>Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic</title><author>Völk, Stefanie ; Pfirrmann, Markus ; Koedel, Uwe ; Pfister, Hans-Walter ; Lang, Thomas ; Scheibe, Franziska ; Salih, Farid ; Herzig-Nichtweiss, Julia ; Zimmermann, Julian ; Alonso, Angelika ; Wittstock, Matthias ; Totzeck, Andreas ; Schramm, Patrick ; Schirotzek, Ingo ; Onur, Oezguer A. ; Pelz, Johann Otto ; Ottomeyer, Caroline ; Luger, Sebastian ; Barlinn, Kristian ; Binder, Tobias ; Wöbker, Gabriele ; Reimann, Gernot ; Urbanek, Christian ; Heckelmann, Jan ; Lochner, Piergiorgio ; Berghoff, Martin ; Schönenberger, Silvia ; Neumann, Bernhard ; Niesen, Wolf-Dirk ; Dohmen, Christian ; Huttner, Hagen B. ; Günther, Albrecht ; Klein, Matthias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e98adaa20697229b358957215da4e15b780812a198fe30ee9a7da0e06936ca1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aseptic meningitis</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Encephalitis</topic><topic>Hospitals</topic><topic>Hygiene</topic><topic>Infections</topic><topic>Mastoiditis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meningitis</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Otitis media</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Respiratory diseases</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Sinusitis</topic><topic>Streptococcus infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Völk, Stefanie</creatorcontrib><creatorcontrib>Pfirrmann, Markus</creatorcontrib><creatorcontrib>Koedel, Uwe</creatorcontrib><creatorcontrib>Pfister, Hans-Walter</creatorcontrib><creatorcontrib>Lang, Thomas</creatorcontrib><creatorcontrib>Scheibe, 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Martin</creatorcontrib><creatorcontrib>Schönenberger, Silvia</creatorcontrib><creatorcontrib>Neumann, Bernhard</creatorcontrib><creatorcontrib>Niesen, Wolf-Dirk</creatorcontrib><creatorcontrib>Dohmen, Christian</creatorcontrib><creatorcontrib>Huttner, Hagen B.</creatorcontrib><creatorcontrib>Günther, Albrecht</creatorcontrib><creatorcontrib>Klein, Matthias</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Völk, Stefanie</au><au>Pfirrmann, Markus</au><au>Koedel, Uwe</au><au>Pfister, Hans-Walter</au><au>Lang, Thomas</au><au>Scheibe, Franziska</au><au>Salih, Farid</au><au>Herzig-Nichtweiss, Julia</au><au>Zimmermann, Julian</au><au>Alonso, Angelika</au><au>Wittstock, Matthias</au><au>Totzeck, Andreas</au><au>Schramm, Patrick</au><au>Schirotzek, Ingo</au><au>Onur, Oezguer A.</au><au>Pelz, Johann Otto</au><au>Ottomeyer, Caroline</au><au>Luger, Sebastian</au><au>Barlinn, Kristian</au><au>Binder, Tobias</au><au>Wöbker, Gabriele</au><au>Reimann, Gernot</au><au>Urbanek, Christian</au><au>Heckelmann, Jan</au><au>Lochner, Piergiorgio</au><au>Berghoff, Martin</au><au>Schönenberger, Silvia</au><au>Neumann, Bernhard</au><au>Niesen, Wolf-Dirk</au><au>Dohmen, Christian</au><au>Huttner, Hagen B.</au><au>Günther, Albrecht</au><au>Klein, Matthias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>269</volume><issue>7</issue><spage>3389</spage><epage>3399</epage><pages>3389-3399</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Background and objectives
In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In consequence, pulmonary infections due to other respiratory pathogens also decreased. Here, we evaluated the number of bacterial and viral meningitis and encephalitis cases during the coronavirus disease 2019 (COVID-19) pandemic.
Methods
In a multicentre retrospective analysis of data from January 2016 until December 2020, numbers of patients diagnosed with bacterial meningitis and other types of CNS infections (such as viral meningitis and encephalitis) at 26 German hospitals were studied. Furthermore, the number of common meningitis-preceding ear-nose-throat infections (sinusitis, mastoiditis and otitis media) was evaluated.
Results
Compared to the previous years, the total number of patients diagnosed with pneumococcal meningitis was reduced (
n
= 64 patients/year in 2020 vs.
n
= 87 to 120 patients/year between 2016 and 2019, all
p
< 0.05). Additionally, the total number of patients diagnosed with otolaryngological infections was significantly lower (
n
= 1181 patients/year in 2020 vs.
n
= 1525 to 1754 patients/year between 2016 and 2019, all
p
< 0.001). We also observed a decline in viral meningitis and especially enterovirus meningitis (
n
= 25 patients/year in 2020 vs.
n
= 97 to 181 patients/year between 2016 and 2019, all
p
< 0.001).
Discussion
This multicentre retrospective analysis demonstrates a decline in the number of patients treated for viral and pneumococcal meningitis as well as otolaryngological infections in 2020 compared to previous years. Since the latter often precedes pneumococcal meningitis, this may point to the significance of the direct spread of pneumococci from an otolaryngological focus such as mastoiditis to the brain as one important pathophysiological route in the development of pneumococcal meningitis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35316388</pmid><doi>10.1007/s00415-022-11034-w</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6929-3831</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5354 |
| ispartof | Journal of neurology, 2022-07, Vol.269 (7), p.3389-3399 |
| issn | 0340-5354 1432-1459 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8938731 |
| source | SpringerLink Journals |
| subjects | Aseptic meningitis Coronaviruses COVID-19 Encephalitis Hospitals Hygiene Infections Mastoiditis Medicine Medicine & Public Health Meningitis Neurology Neuroradiology Neurosciences Original Communication Otitis media Pandemics Patients Respiratory diseases Severe acute respiratory syndrome coronavirus 2 Sinusitis Streptococcus infections |
| title | Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T08%3A41%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decline%20in%20the%20number%20of%20patients%20with%20meningitis%20in%20German%20hospitals%20during%20the%20COVID-19%20pandemic&rft.jtitle=Journal%20of%20neurology&rft.au=V%C3%B6lk,%20Stefanie&rft.date=2022-07-01&rft.volume=269&rft.issue=7&rft.spage=3389&rft.epage=3399&rft.pages=3389-3399&rft.issn=0340-5354&rft.eissn=1432-1459&rft_id=info:doi/10.1007/s00415-022-11034-w&rft_dat=%3Cproquest_pubme%3E2679455325%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2679455325&rft_id=info:pmid/35316388&rfr_iscdi=true |