Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism

It is well established that glutamate plays an important role in drug-induced and cue-induced reinstatement of drug seeking. However, the role of glutamate in drug reward is unclear. In this study, we systemically evaluated the effects of multiple glutamate transporter (GLT) inhibitors on extracellu...

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Veröffentlicht in:	The Journal of neuroscience 2022-03, Vol.42 (11), p.2327-2343
Hauptverfasser:	Yang, Hong-Ju, Hempel, Briana J, Bi, Guo-Hua, He, Yi, Zhang, Hai-Ying, Gardner, Eliot L, Xi, Zheng-Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System X-AG - metabolism Animals Antisense oligonucleotides Antisense therapy Astrocytes - metabolism Brain Caudate-putamen Cocaine Cocaine - pharmacology Cocaine-Related Disorders - metabolism DARPP-32 protein Dopamine Drug abuse Drug addiction Drug dosages Drug self-administration Female Glutamic Acid - metabolism Glutamic acid receptors (ionotropic) Glutamic acid transporter Inhibitors Intravenous administration Male N-Methyl-D-aspartic acid receptors N-Methylaspartate - pharmacology Neostriatum Nucleus Accumbens Oligonucleotides Pallidum (ventral) Rats Receptors Receptors, N-Methyl-D-Aspartate Reinforcement Reinforcement schedules Reinstatement Rodents Self Administration Spiny neurons Ventral tegmentum α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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