Spectroscopic and Computational Investigation of the Epoxyqueuosine Reductase QueG Reveals Intriguing Similarities with the Reductive Dehalogenase PceA

Queuosine (Q) is a highly modified nucleoside of transfer RNA that is formed from guanosine triphosphate over the course of eight steps. The final step in this process, involving the conversion of epoxyqueuosine (oQ) to Q, is catalyzed by the enzyme QueG. A recent X-ray crystallographic study reveal...

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Veröffentlicht in:	Biochemistry (Easton) 2022-02, Vol.61 (3), p.195-205
Hauptverfasser:	Greenhalgh, Elizabeth D, Kincannon, William, Bandarian, Vahe, Brunold, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus subtilis Catalysis Circular Dichroism - methods Cobalt - chemistry Crystallography, X-Ray - methods Density Functional Theory Electron Spin Resonance Spectroscopy - methods Models, Molecular Nucleoside Q - analogs & derivatives Nucleoside Q - chemistry Oxidoreductases - chemistry RNA, Transfer - chemistry Vitamin B 12 - chemistry
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