VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells

Haematopoietic stem cells (HSCs) home to the bone marrow via, in part, interactions with vascular cell adhesion molecule-1 (VCAM1) 1 – 3 . Once in the bone marrow, HSCs are vetted by perivascular phagocytes to ensure their self-integrity. Here we show that VCAM1 is also expressed on healthy HSCs and...

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Veröffentlicht in:	Nature cell biology 2022-03, Vol.24 (3), p.290-298
Hauptverfasser:	Pinho, Sandra, Wei, Qiaozhi, Maryanovich, Maria, Zhang, Dachuan, Balandrán, Juan Carlos, Pierce, Halley, Nakahara, Fumio, Di Staulo, Anna, Bartholdy, Boris A., Xu, Jianing, Borger, Daniel K., Verma, Amit, Frenette, Paul S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/106 13/31 14 59 59/5 631/250/2161 631/532/1542 631/67/71 64 64/60 82 Acute myeloid leukemia Biomedical and Life Sciences Bone Marrow Cancer Cancer Research Cell adhesion Cell adhesion molecules Cell Biology Clearances Deletion Developmental Biology Haplotypes Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Humans Immune clearance Immune Tolerance Immunoglobulins Immunological tolerance Immunosurveillance Letter Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukocytes (mononuclear) Life Sciences Major histocompatibility complex Medical prognosis Neoplastic Stem Cells Phagocytes Stem Cells Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism β2 Microglobulin
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