The spectrum of sex differences in cancer

The spectrum of sex differences in cancer

Sex differences in cellular and systems biology have been evolutionarily selected to optimize reproductive success in all species with little (sperm) and big (ova) gamete producers. They are evident from the time of fertilization and accrue throughout development through genetic, epigenetic, and cir...

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Veröffentlicht in:Trends in Cancer 2022-04, Vol.8 (4), p.303-315
1. Verfasser: Rubin, Joshua B
Format: Artikel
Sprache:eng
Schlagworte:
Female
Humans
Male
Neoplasms - genetics
Neoplasms - metabolism
Protein Processing, Post-Translational
Sex Characteristics
Spermatozoa - metabolism
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creator Rubin, Joshua B
description Sex differences in cellular and systems biology have been evolutionarily selected to optimize reproductive success in all species with little (sperm) and big (ova) gamete producers. They are evident from the time of fertilization and accrue throughout development through genetic, epigenetic, and circulating sex hormone-dependent mechanisms. Among other effects, they significantly impact on chromatin organization, metabolism, cell cycle regulation, immunity, longevity, and cancer risk and survival. Sex differences in cancer should be expected and accounted for in basic, translational, and clinical oncology research.
doi_str_mv 10.1016/j.trecan.2022.01.013
format Article
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source MEDLINE; Alma/SFX Local Collection
subjects Female
Humans
Male
Neoplasms - genetics
Neoplasms - metabolism
Protein Processing, Post-Translational
Sex Characteristics
Spermatozoa - metabolism
title The spectrum of sex differences in cancer
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