Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells

Proper segregation of chromosomes during mitosis depends on “amphitelic attachments”—load-bearing connections of sister kinetochores to the opposite spindle poles via bundles of microtubules, termed as the “K-fibers.” Current models of spindle assembly assume that K-fibers arise largely from stochas...

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Veröffentlicht in:	Current biology 2022-03, Vol.32 (5), p.1049-1063.e4
Hauptverfasser:	Renda, Fioranna, Miles, Christopher, Tikhonenko, Irina, Fisher, Rebecca, Carlini, Lina, Kapoor, Tarun M., Mogilner, Alex, Khodjakov, Alexey
Format:	Artikel
Sprache:	eng
Schlagworte:	agent-based simulation Chromosome Segregation computational model Humans kinetochore Kinetochores Microtubules Mitosis Spindle Apparatus spindle assembly
Online-Zugang:	Volltext
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