Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential...

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Veröffentlicht in:	Lancet neurology 2022-04, Vol.21 (4), p.329-341
Hauptverfasser:	Li, Yan, Nuscher, Brigitte, Franzmeier, Nicolai, Xiong, Chengjie, Hassenstab, Jason, McDade, Eric, Feederle, Regina, Karch, Celeste M, Schlepckow, Kai, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Haass, Christian, Adams, Sarah, Allegri, Ricardo, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chrem, Patricio, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Duong, Duc, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Groves, Alex, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ishii, Kenji, Jerome, Gina, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Koeppe, Robert, Kuder-Buletta, Elke, Levey, Allan, Lopez, Oscar, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, MountzMD, James, Nadkarni, Neelesh, Nagamatsu, Akemi, Norton, Joanne, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Schofield, Peter, Senda, Michio, Seyfried, Nick, Shady, Kristine, Sigurdson, Wendy, Smith, Jennifer, Sohrabi, Hamid, Taddei, Kevin, Thompson, Sarah, Wang, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides Animal models Biomarkers Cerebrospinal fluid Coding Cognition & reasoning Cognition - physiology Cognitive ability Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - genetics Cortex (parietal) Dementia disorders Hippocampus Humans Magnetic resonance imaging Membrane Glycoproteins - cerebrospinal fluid Membrane Glycoproteins - genetics Middle Aged Mutation Neurodegenerative diseases Neuroimaging Observational studies Pathology Positron emission tomography Receptors, Immunologic - genetics Statistical analysis Tau protein Threonine United States
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