Human Coxsackie- and adenovirus receptor is a putative target of neutrophil elastase-mediated shedding

Background During viral-induced myocarditis, immune cells migrate towards the site of infection and secrete proteases, which in turn can act as sheddases by cleaving extracellular domains of transmembrane proteins. We were interested in the shedding of the Coxsackie- and adenovirus receptor (CAR) th...

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Veröffentlicht in:	Molecular biology reports 2022-04, Vol.49 (4), p.3213-3223
Hauptverfasser:	Herrmann, Leonie, Schelletter, Louise, Hoffrogge, Raimund, Niehaus, Karsten, Rudolph, Volker, Farr, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cardiomyocytes Cathepsin G Cell migration Coxsackie and Adenovirus Receptor-Like Membrane Protein Elastase Flow cytometry Heart diseases Histology Humans Immunofluorescence Leukocyte Elastase Leukocytes (neutrophilic) Life Sciences Matrix metalloproteinase Membrane proteins Morphology Myocarditis Neutrophils Original Original Article Proteinase 3 Proteolysis Receptors, Virus Serine proteinase Tandem Mass Spectrometry
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