Gallic acid-coated silver nanoparticles as perspective drug nanocarriers: bioanalytical study
The ability of silver nanoparticles (AgNPs) to be used as drug nanocarriers has helped rapidly to invent novel strategies to treat diseases, such as cancer. The nanoparticles may offer a valuable tool to novel pH-sensitive drug delivery systems in the present scenario because of their undergoing mec...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2022-07, Vol.414 (18), p.5493-5505 |
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| creator | Nemčeková, Katarína Svitková, Veronika Sochr, Jozef Gemeiner, Pavol Labuda, Ján |
| description | The ability of silver nanoparticles (AgNPs) to be used as drug nanocarriers has helped rapidly to invent novel strategies to treat diseases, such as cancer. The nanoparticles may offer a valuable tool to novel pH-sensitive drug delivery systems in the present scenario because of their undergoing mechanisms associated with the regulated dissolution, aggregation, and generation of oxygen radicals as well. These processes could be monitored by electrochemical (bio)sensors that are less money and time-consuming compared to other analytical approaches, however, with comparable analytical performance. In this paper, synthesized and microscopically characterized gallic acid-coated AgNPs (GA-AgNPs) are investigated using spectral and electrochemical methods. To investigate the Ag
+
release, a 21-day ageing experiment is performed spectrophotometrically, finding that the peak maximum of GA-AgNPs spectra diminished by 24.5%. The highest Ag
+
content was electrochemically determined in the supernatant solution after centrifugation (6.97 μmol·L
−1
), while no significant concentration of silver ions in solution after redispersion was observed (1.26 μmol·L
−1
). The interaction experiment indicates a stabilization of GA-AgNPs in the presence of long-chain dsDNA as well as a mutual electrostatic interaction with DNA sugar-phosphate backbone. This interaction mechanism is confirmed by FTIR analysis, showing a shift (1049 to 1061 cm
−1
and 913 to 964 cm
−1
) specific to DNA phosphate bands. Finally, doxorubicin-loaded GA-AgNPs are monitored for the specific drug release in the physiological and more reactive weakly acidic microenvironment. Hereby, electrochemical (bio)sensing of GA-AgNPs undergoing mechanisms shows a huge potential to be used for monitoring of drug delivery systems at cancer therapy.
Graphical abstract |
| doi_str_mv | 10.1007/s00216-022-03955-2 |
| format | Article |
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+
release, a 21-day ageing experiment is performed spectrophotometrically, finding that the peak maximum of GA-AgNPs spectra diminished by 24.5%. The highest Ag
+
content was electrochemically determined in the supernatant solution after centrifugation (6.97 μmol·L
−1
), while no significant concentration of silver ions in solution after redispersion was observed (1.26 μmol·L
−1
). The interaction experiment indicates a stabilization of GA-AgNPs in the presence of long-chain dsDNA as well as a mutual electrostatic interaction with DNA sugar-phosphate backbone. This interaction mechanism is confirmed by FTIR analysis, showing a shift (1049 to 1061 cm
−1
and 913 to 964 cm
−1
) specific to DNA phosphate bands. Finally, doxorubicin-loaded GA-AgNPs are monitored for the specific drug release in the physiological and more reactive weakly acidic microenvironment. Hereby, electrochemical (bio)sensing of GA-AgNPs undergoing mechanisms shows a huge potential to be used for monitoring of drug delivery systems at cancer therapy.
Graphical abstract</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-022-03955-2</identifier><identifier>PMID: 35294597</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aging ; Analytical Chemistry ; Biochemistry ; Cancer ; Centrifugation ; Characterization and Evaluation of Materials ; Chemical sensors ; Chemistry ; Chemistry and Materials Science ; Deoxyribonucleic acid ; DNA ; Doxorubicin ; Drug delivery ; Drug delivery systems ; Drugs ; Electrochemistry ; Electrostatic properties ; Food Science ; Gallic acid ; Health aspects ; Laboratory Medicine ; Methods ; Microenvironments ; Monitoring/Environmental Analysis ; Nanoparticles ; pH effects ; Promising Early-Career (Bio)Analytical Researchers ; Research Paper ; Silver ; Spectrophotometry ; Vehicles</subject><ispartof>Analytical and bioanalytical chemistry, 2022-07, Vol.414 (18), p.5493-5505</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-4d588e098de967d8daf5fa13ddc24dab383879f7d48919d8bbf0504f8551323b3</citedby><cites>FETCH-LOGICAL-c541t-4d588e098de967d8daf5fa13ddc24dab383879f7d48919d8bbf0504f8551323b3</cites><orcidid>0000-0002-8048-5735</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-022-03955-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-022-03955-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35294597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nemčeková, Katarína</creatorcontrib><creatorcontrib>Svitková, Veronika</creatorcontrib><creatorcontrib>Sochr, Jozef</creatorcontrib><creatorcontrib>Gemeiner, Pavol</creatorcontrib><creatorcontrib>Labuda, Ján</creatorcontrib><title>Gallic acid-coated silver nanoparticles as perspective drug nanocarriers: bioanalytical study</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>The ability of silver nanoparticles (AgNPs) to be used as drug nanocarriers has helped rapidly to invent novel strategies to treat diseases, such as cancer. The nanoparticles may offer a valuable tool to novel pH-sensitive drug delivery systems in the present scenario because of their undergoing mechanisms associated with the regulated dissolution, aggregation, and generation of oxygen radicals as well. These processes could be monitored by electrochemical (bio)sensors that are less money and time-consuming compared to other analytical approaches, however, with comparable analytical performance. In this paper, synthesized and microscopically characterized gallic acid-coated AgNPs (GA-AgNPs) are investigated using spectral and electrochemical methods. To investigate the Ag
+
release, a 21-day ageing experiment is performed spectrophotometrically, finding that the peak maximum of GA-AgNPs spectra diminished by 24.5%. The highest Ag
+
content was electrochemically determined in the supernatant solution after centrifugation (6.97 μmol·L
−1
), while no significant concentration of silver ions in solution after redispersion was observed (1.26 μmol·L
−1
). The interaction experiment indicates a stabilization of GA-AgNPs in the presence of long-chain dsDNA as well as a mutual electrostatic interaction with DNA sugar-phosphate backbone. This interaction mechanism is confirmed by FTIR analysis, showing a shift (1049 to 1061 cm
−1
and 913 to 964 cm
−1
) specific to DNA phosphate bands. Finally, doxorubicin-loaded GA-AgNPs are monitored for the specific drug release in the physiological and more reactive weakly acidic microenvironment. Hereby, electrochemical (bio)sensing of GA-AgNPs undergoing mechanisms shows a huge potential to be used for monitoring of drug delivery systems at cancer therapy.
Graphical abstract</description><subject>Aging</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Cancer</subject><subject>Centrifugation</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical sensors</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Doxorubicin</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Electrochemistry</subject><subject>Electrostatic properties</subject><subject>Food Science</subject><subject>Gallic acid</subject><subject>Health aspects</subject><subject>Laboratory Medicine</subject><subject>Methods</subject><subject>Microenvironments</subject><subject>Monitoring/Environmental Analysis</subject><subject>Nanoparticles</subject><subject>pH effects</subject><subject>Promising Early-Career (Bio)Analytical 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study</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>414</volume><issue>18</issue><spage>5493</spage><epage>5505</epage><pages>5493-5505</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>The ability of silver nanoparticles (AgNPs) to be used as drug nanocarriers has helped rapidly to invent novel strategies to treat diseases, such as cancer. The nanoparticles may offer a valuable tool to novel pH-sensitive drug delivery systems in the present scenario because of their undergoing mechanisms associated with the regulated dissolution, aggregation, and generation of oxygen radicals as well. These processes could be monitored by electrochemical (bio)sensors that are less money and time-consuming compared to other analytical approaches, however, with comparable analytical performance. In this paper, synthesized and microscopically characterized gallic acid-coated AgNPs (GA-AgNPs) are investigated using spectral and electrochemical methods. To investigate the Ag
+
release, a 21-day ageing experiment is performed spectrophotometrically, finding that the peak maximum of GA-AgNPs spectra diminished by 24.5%. The highest Ag
+
content was electrochemically determined in the supernatant solution after centrifugation (6.97 μmol·L
−1
), while no significant concentration of silver ions in solution after redispersion was observed (1.26 μmol·L
−1
). The interaction experiment indicates a stabilization of GA-AgNPs in the presence of long-chain dsDNA as well as a mutual electrostatic interaction with DNA sugar-phosphate backbone. This interaction mechanism is confirmed by FTIR analysis, showing a shift (1049 to 1061 cm
−1
and 913 to 964 cm
−1
) specific to DNA phosphate bands. Finally, doxorubicin-loaded GA-AgNPs are monitored for the specific drug release in the physiological and more reactive weakly acidic microenvironment. Hereby, electrochemical (bio)sensing of GA-AgNPs undergoing mechanisms shows a huge potential to be used for monitoring of drug delivery systems at cancer therapy.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35294597</pmid><doi>10.1007/s00216-022-03955-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8048-5735</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Analytical Chemistry Biochemistry Cancer Centrifugation Characterization and Evaluation of Materials Chemical sensors Chemistry Chemistry and Materials Science Deoxyribonucleic acid DNA Doxorubicin Drug delivery Drug delivery systems Drugs Electrochemistry Electrostatic properties Food Science Gallic acid Health aspects Laboratory Medicine Methods Microenvironments Monitoring/Environmental Analysis Nanoparticles pH effects Promising Early-Career (Bio)Analytical Researchers Research Paper Silver Spectrophotometry Vehicles |
| title | Gallic acid-coated silver nanoparticles as perspective drug nanocarriers: bioanalytical study |
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