Copper Oxide Nanoparticle-Decorated Carbon Nanoparticle Composite Colloidal Preparation through Laser Ablation for Antimicrobial and Antiproliferative Actions against Breast Cancer Cell Line, MCF-7
Copper oxide (CuO) nanoparticle- (NP-) decorated carbon NPs (CNPs) were produced as colloidal suspension through pulsed laser ablation technique in liquid (PLAL) medium. The antimicrobial activity of the produced NPs was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli)...
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| Veröffentlicht in: | BioMed research international 2022, Vol.2022 (1), p.9863616-9863616 |
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| creator | Mohammed, Salman A. A. Khashan, Khawla S. Jabir, Majid S. Abdulameer, Farah A. Sulaiman, Ghassan M. Al-Omar, Mohsen S. Mohammed, Hamdoon A. Hadi, Aseel A. Khan, Riaz A. |
| description | Copper oxide (CuO) nanoparticle- (NP-) decorated carbon NPs (CNPs) were produced as colloidal suspension through pulsed laser ablation technique in liquid (PLAL) medium. The antimicrobial activity of the produced NPs was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), and anticancer activity was tested against breast cancer cell line, MCF-7, together with the biocompatibility assessment of these NPs. The X-ray diffraction (XRD) patterns of the obtained CNPs showed peaks at 26.58° and 43.78° (2θ) identical to (002) and (111) planes, respectively, of the carbon phases. It also displayed new peaks at 38.5° and 48.64° (2θ) after doping with CuO NPs. Transmission electron microscope (TEM) images revealed the crystalline nature with the spherical shape of the prepared CNPs with 5-40 nm diameter ranges. In addition, the NP effects on the bacterial cell walls and nucleic acid were confirmed using a scanning electron microscope (SEM) and microscopic fluorescence analysis. The NPs showed antibacterial activity through SEM examinations against the pathogenic microbial species, S. aureus and E. coli. In the cellular material release assay, the optical density of the bacterial cells, treated with NPs, displayed a significant increase with the time of exposure to NPs, and the cytotoxicity reached more than 80% of the level for the CNPs decorated with CuO NPs. The morphology of the MCF-7 cells treated with NPs decreased numbers, and the loss of contact with the surrounding cells was observed. These results confirmed that the CNPs decorated with CuO NPs have no observable side effects and can be safely used for therapeutic applications. It is also noteworthy that it is the first report of preparation of CuO NPs decorated with CNPs (CuO NPs-CNPs) by PLAL, and the produced NPs showed antimicrobial antiproliferative activities against breast cancer cell lines, MCF-7. The main advantage of the PLAL technique of synthesizing CuO NPs-CNPs provided a two-step, cost-effective, and eco-friendly method. |
| doi_str_mv | 10.1155/2022/9863616 |
| format | Article |
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A. ; Khashan, Khawla S. ; Jabir, Majid S. ; Abdulameer, Farah A. ; Sulaiman, Ghassan M. ; Al-Omar, Mohsen S. ; Mohammed, Hamdoon A. ; Hadi, Aseel A. ; Khan, Riaz A.</creator><contributor>Ansari, Irfan A.</contributor><creatorcontrib>Mohammed, Salman A. A. ; Khashan, Khawla S. ; Jabir, Majid S. ; Abdulameer, Farah A. ; Sulaiman, Ghassan M. ; Al-Omar, Mohsen S. ; Mohammed, Hamdoon A. ; Hadi, Aseel A. ; Khan, Riaz A. ; Ansari, Irfan A.</creatorcontrib><description>Copper oxide (CuO) nanoparticle- (NP-) decorated carbon NPs (CNPs) were produced as colloidal suspension through pulsed laser ablation technique in liquid (PLAL) medium. The antimicrobial activity of the produced NPs was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), and anticancer activity was tested against breast cancer cell line, MCF-7, together with the biocompatibility assessment of these NPs. The X-ray diffraction (XRD) patterns of the obtained CNPs showed peaks at 26.58° and 43.78° (2θ) identical to (002) and (111) planes, respectively, of the carbon phases. It also displayed new peaks at 38.5° and 48.64° (2θ) after doping with CuO NPs. Transmission electron microscope (TEM) images revealed the crystalline nature with the spherical shape of the prepared CNPs with 5-40 nm diameter ranges. In addition, the NP effects on the bacterial cell walls and nucleic acid were confirmed using a scanning electron microscope (SEM) and microscopic fluorescence analysis. The NPs showed antibacterial activity through SEM examinations against the pathogenic microbial species, S. aureus and E. coli. In the cellular material release assay, the optical density of the bacterial cells, treated with NPs, displayed a significant increase with the time of exposure to NPs, and the cytotoxicity reached more than 80% of the level for the CNPs decorated with CuO NPs. The morphology of the MCF-7 cells treated with NPs decreased numbers, and the loss of contact with the surrounding cells was observed. These results confirmed that the CNPs decorated with CuO NPs have no observable side effects and can be safely used for therapeutic applications. It is also noteworthy that it is the first report of preparation of CuO NPs decorated with CNPs (CuO NPs-CNPs) by PLAL, and the produced NPs showed antimicrobial antiproliferative activities against breast cancer cell lines, MCF-7. The main advantage of the PLAL technique of synthesizing CuO NPs-CNPs provided a two-step, cost-effective, and eco-friendly method.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/9863616</identifier><identifier>PMID: 35299896</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Ablation ; Ablation (Vaporization technology) ; Anti-infective agents ; Antibacterial activity ; Anticancer properties ; Antimicrobial activity ; Antimicrobial agents ; Antimitotic agents ; Antineoplastic agents ; Antiproliferatives ; Antitumor activity ; Apoptosis ; Biocompatibility ; Breast cancer ; Breast Neoplasms - drug therapy ; Cancer therapies ; Carbon ; Carbon - chemistry ; Carbon - pharmacology ; Care and treatment ; Cell walls ; Colloids ; Colloids - chemistry ; Colloids - pharmacology ; Copper ; Copper - chemistry ; Copper - pharmacology ; Copper oxide ; Copper oxides ; Cuprite ; Cytology ; Cytotoxicity ; Decoration ; Diffraction patterns ; E coli ; Escherichia coli ; Escherichia coli - drug effects ; Female ; Fluorescence ; Health aspects ; Humans ; Image transmission ; Investigations ; Laser ablation ; Laser Therapy ; Lasers ; MCF-7 Cells ; Metal Nanoparticles - chemistry ; Metal oxides ; Microorganisms ; Morphology ; Nanomaterials ; Nanoparticles ; Nanostructured materials ; Nucleic acids ; Optical density ; Pharmaceutical research ; Production processes ; Pulsed lasers ; Scanning electron microscopy ; Side effects ; Silicon wafers ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Therapeutic applications ; Thin films ; Toxicity ; Tumor cell lines ; X-ray diffraction</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.9863616-9863616</ispartof><rights>Copyright © 2022 Salman A. A. Mohammed et al.</rights><rights>COPYRIGHT 2022 John Wiley & Sons, Inc.</rights><rights>Copyright © 2022 Salman A. A. Mohammed et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Salman A. A. Mohammed et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-889e9837611f05dc71791e11b408d7f213ef7872373dc206223067588446a203</citedby><cites>FETCH-LOGICAL-c476t-889e9837611f05dc71791e11b408d7f213ef7872373dc206223067588446a203</cites><orcidid>0000-0003-0759-8298 ; 0000-0003-2896-6790 ; 0000-0001-8134-9623 ; 0000-0002-9250-100X ; 0000-0001-9028-9191 ; 0000-0003-0185-0149 ; 0000-0001-6388-3849</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923787/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923787/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35299896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ansari, Irfan A.</contributor><creatorcontrib>Mohammed, Salman A. A.</creatorcontrib><creatorcontrib>Khashan, Khawla S.</creatorcontrib><creatorcontrib>Jabir, Majid S.</creatorcontrib><creatorcontrib>Abdulameer, Farah A.</creatorcontrib><creatorcontrib>Sulaiman, Ghassan M.</creatorcontrib><creatorcontrib>Al-Omar, Mohsen S.</creatorcontrib><creatorcontrib>Mohammed, Hamdoon A.</creatorcontrib><creatorcontrib>Hadi, Aseel A.</creatorcontrib><creatorcontrib>Khan, Riaz A.</creatorcontrib><title>Copper Oxide Nanoparticle-Decorated Carbon Nanoparticle Composite Colloidal Preparation through Laser Ablation for Antimicrobial and Antiproliferative Actions against Breast Cancer Cell Line, MCF-7</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Copper oxide (CuO) nanoparticle- (NP-) decorated carbon NPs (CNPs) were produced as colloidal suspension through pulsed laser ablation technique in liquid (PLAL) medium. The antimicrobial activity of the produced NPs was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), and anticancer activity was tested against breast cancer cell line, MCF-7, together with the biocompatibility assessment of these NPs. The X-ray diffraction (XRD) patterns of the obtained CNPs showed peaks at 26.58° and 43.78° (2θ) identical to (002) and (111) planes, respectively, of the carbon phases. It also displayed new peaks at 38.5° and 48.64° (2θ) after doping with CuO NPs. Transmission electron microscope (TEM) images revealed the crystalline nature with the spherical shape of the prepared CNPs with 5-40 nm diameter ranges. In addition, the NP effects on the bacterial cell walls and nucleic acid were confirmed using a scanning electron microscope (SEM) and microscopic fluorescence analysis. The NPs showed antibacterial activity through SEM examinations against the pathogenic microbial species, S. aureus and E. coli. In the cellular material release assay, the optical density of the bacterial cells, treated with NPs, displayed a significant increase with the time of exposure to NPs, and the cytotoxicity reached more than 80% of the level for the CNPs decorated with CuO NPs. The morphology of the MCF-7 cells treated with NPs decreased numbers, and the loss of contact with the surrounding cells was observed. These results confirmed that the CNPs decorated with CuO NPs have no observable side effects and can be safely used for therapeutic applications. It is also noteworthy that it is the first report of preparation of CuO NPs decorated with CNPs (CuO NPs-CNPs) by PLAL, and the produced NPs showed antimicrobial antiproliferative activities against breast cancer cell lines, MCF-7. The main advantage of the PLAL technique of synthesizing CuO NPs-CNPs provided a two-step, cost-effective, and eco-friendly method.</description><subject>Ablation</subject><subject>Ablation (Vaporization technology)</subject><subject>Anti-infective agents</subject><subject>Antibacterial activity</subject><subject>Anticancer properties</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Antiproliferatives</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Biocompatibility</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Cancer therapies</subject><subject>Carbon</subject><subject>Carbon - chemistry</subject><subject>Carbon - pharmacology</subject><subject>Care and treatment</subject><subject>Cell walls</subject><subject>Colloids</subject><subject>Colloids - chemistry</subject><subject>Colloids - pharmacology</subject><subject>Copper</subject><subject>Copper - chemistry</subject><subject>Copper - pharmacology</subject><subject>Copper oxide</subject><subject>Copper oxides</subject><subject>Cuprite</subject><subject>Cytology</subject><subject>Cytotoxicity</subject><subject>Decoration</subject><subject>Diffraction patterns</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Image transmission</subject><subject>Investigations</subject><subject>Laser ablation</subject><subject>Laser Therapy</subject><subject>Lasers</subject><subject>MCF-7 Cells</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal oxides</subject><subject>Microorganisms</subject><subject>Morphology</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanostructured materials</subject><subject>Nucleic acids</subject><subject>Optical density</subject><subject>Pharmaceutical research</subject><subject>Production processes</subject><subject>Pulsed lasers</subject><subject>Scanning electron microscopy</subject><subject>Side effects</subject><subject>Silicon wafers</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Therapeutic applications</subject><subject>Thin films</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>X-ray diffraction</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk1vEzEQhlcIRKvSG2dkiQsSXeqPjT8uSGFLASlQDr1bjnc2ceXYi70p9Afyv_A2IVAO-DLjmWdee-ypqucEvyFkNjunmNJzJTnjhD-qjikjTc1JQx4ffMaOqtOcb3BZknCs-NPqiM2oUlLx4-pnG4cBErr64TpAX0yIg0mjsx7qC7AxmRE61Jq0jOFBFrVxM8TsxsnzPrrOePQ1Qcmb0RV4XKe4Xa3RwuQiP1_6XbiPZRNGt3E2xaUrRSZ095EhRe96mMpvAc3thGdkVsaFPKJ3CUwxrQm2yLXgPVq4AGfoc3tZi2fVk974DKd7e1JdX76_bj_Wi6sPn9r5oraN4GMtpQIlmeCE9HjWWUGEIkDIssGyEz0lDHohBWWCdZZiTinDXMykbBpuKGYn1dud7LBdbqCzEMZkvB6S25h0p6Nx-mEmuLVexVstVdGUogi82guk-G0LedQbl21pxgSI26wpb7BSqvxqQV_-g97EbQqlu3tKlh9k7A-1Mh60C30s59pJVM-5EryhjSKFOttR5c1zTtAfrkywnuZIT3Ok93NU8Bd_t3mAf09NAV7vgLULnfnu_i_3C0eg0Gw</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Mohammed, Salman A. 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A. ; Khashan, Khawla S. ; Jabir, Majid S. ; Abdulameer, Farah A. ; Sulaiman, Ghassan M. ; Al-Omar, Mohsen S. ; Mohammed, Hamdoon A. ; Hadi, Aseel A. ; Khan, Riaz A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-889e9837611f05dc71791e11b408d7f213ef7872373dc206223067588446a203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ablation</topic><topic>Ablation (Vaporization technology)</topic><topic>Anti-infective agents</topic><topic>Antibacterial activity</topic><topic>Anticancer properties</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Antiproliferatives</topic><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Biocompatibility</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Cancer therapies</topic><topic>Carbon</topic><topic>Carbon - chemistry</topic><topic>Carbon - pharmacology</topic><topic>Care and treatment</topic><topic>Cell walls</topic><topic>Colloids</topic><topic>Colloids - chemistry</topic><topic>Colloids - pharmacology</topic><topic>Copper</topic><topic>Copper - chemistry</topic><topic>Copper - pharmacology</topic><topic>Copper oxide</topic><topic>Copper oxides</topic><topic>Cuprite</topic><topic>Cytology</topic><topic>Cytotoxicity</topic><topic>Decoration</topic><topic>Diffraction patterns</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Image transmission</topic><topic>Investigations</topic><topic>Laser ablation</topic><topic>Laser Therapy</topic><topic>Lasers</topic><topic>MCF-7 Cells</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal oxides</topic><topic>Microorganisms</topic><topic>Morphology</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanostructured materials</topic><topic>Nucleic acids</topic><topic>Optical density</topic><topic>Pharmaceutical research</topic><topic>Production processes</topic><topic>Pulsed lasers</topic><topic>Scanning electron microscopy</topic><topic>Side effects</topic><topic>Silicon wafers</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Therapeutic applications</topic><topic>Thin films</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohammed, Salman A. A.</creatorcontrib><creatorcontrib>Khashan, Khawla S.</creatorcontrib><creatorcontrib>Jabir, Majid S.</creatorcontrib><creatorcontrib>Abdulameer, Farah A.</creatorcontrib><creatorcontrib>Sulaiman, Ghassan M.</creatorcontrib><creatorcontrib>Al-Omar, Mohsen S.</creatorcontrib><creatorcontrib>Mohammed, Hamdoon A.</creatorcontrib><creatorcontrib>Hadi, Aseel A.</creatorcontrib><creatorcontrib>Khan, Riaz A.</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohammed, Salman A. A.</au><au>Khashan, Khawla S.</au><au>Jabir, Majid S.</au><au>Abdulameer, Farah A.</au><au>Sulaiman, Ghassan M.</au><au>Al-Omar, Mohsen S.</au><au>Mohammed, Hamdoon A.</au><au>Hadi, Aseel A.</au><au>Khan, Riaz A.</au><au>Ansari, Irfan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Copper Oxide Nanoparticle-Decorated Carbon Nanoparticle Composite Colloidal Preparation through Laser Ablation for Antimicrobial and Antiproliferative Actions against Breast Cancer Cell Line, MCF-7</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>9863616</spage><epage>9863616</epage><pages>9863616-9863616</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Copper oxide (CuO) nanoparticle- (NP-) decorated carbon NPs (CNPs) were produced as colloidal suspension through pulsed laser ablation technique in liquid (PLAL) medium. The antimicrobial activity of the produced NPs was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), and anticancer activity was tested against breast cancer cell line, MCF-7, together with the biocompatibility assessment of these NPs. The X-ray diffraction (XRD) patterns of the obtained CNPs showed peaks at 26.58° and 43.78° (2θ) identical to (002) and (111) planes, respectively, of the carbon phases. It also displayed new peaks at 38.5° and 48.64° (2θ) after doping with CuO NPs. Transmission electron microscope (TEM) images revealed the crystalline nature with the spherical shape of the prepared CNPs with 5-40 nm diameter ranges. In addition, the NP effects on the bacterial cell walls and nucleic acid were confirmed using a scanning electron microscope (SEM) and microscopic fluorescence analysis. The NPs showed antibacterial activity through SEM examinations against the pathogenic microbial species, S. aureus and E. coli. In the cellular material release assay, the optical density of the bacterial cells, treated with NPs, displayed a significant increase with the time of exposure to NPs, and the cytotoxicity reached more than 80% of the level for the CNPs decorated with CuO NPs. The morphology of the MCF-7 cells treated with NPs decreased numbers, and the loss of contact with the surrounding cells was observed. These results confirmed that the CNPs decorated with CuO NPs have no observable side effects and can be safely used for therapeutic applications. It is also noteworthy that it is the first report of preparation of CuO NPs decorated with CNPs (CuO NPs-CNPs) by PLAL, and the produced NPs showed antimicrobial antiproliferative activities against breast cancer cell lines, MCF-7. The main advantage of the PLAL technique of synthesizing CuO NPs-CNPs provided a two-step, cost-effective, and eco-friendly method.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35299896</pmid><doi>10.1155/2022/9863616</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0759-8298</orcidid><orcidid>https://orcid.org/0000-0003-2896-6790</orcidid><orcidid>https://orcid.org/0000-0001-8134-9623</orcidid><orcidid>https://orcid.org/0000-0002-9250-100X</orcidid><orcidid>https://orcid.org/0000-0001-9028-9191</orcidid><orcidid>https://orcid.org/0000-0003-0185-0149</orcidid><orcidid>https://orcid.org/0000-0001-6388-3849</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2022, Vol.2022 (1), p.9863616-9863616 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8923787 |
| source | MEDLINE; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Ablation Ablation (Vaporization technology) Anti-infective agents Antibacterial activity Anticancer properties Antimicrobial activity Antimicrobial agents Antimitotic agents Antineoplastic agents Antiproliferatives Antitumor activity Apoptosis Biocompatibility Breast cancer Breast Neoplasms - drug therapy Cancer therapies Carbon Carbon - chemistry Carbon - pharmacology Care and treatment Cell walls Colloids Colloids - chemistry Colloids - pharmacology Copper Copper - chemistry Copper - pharmacology Copper oxide Copper oxides Cuprite Cytology Cytotoxicity Decoration Diffraction patterns E coli Escherichia coli Escherichia coli - drug effects Female Fluorescence Health aspects Humans Image transmission Investigations Laser ablation Laser Therapy Lasers MCF-7 Cells Metal Nanoparticles - chemistry Metal oxides Microorganisms Morphology Nanomaterials Nanoparticles Nanostructured materials Nucleic acids Optical density Pharmaceutical research Production processes Pulsed lasers Scanning electron microscopy Side effects Silicon wafers Staphylococcus aureus Staphylococcus aureus - drug effects Therapeutic applications Thin films Toxicity Tumor cell lines X-ray diffraction |
| title | Copper Oxide Nanoparticle-Decorated Carbon Nanoparticle Composite Colloidal Preparation through Laser Ablation for Antimicrobial and Antiproliferative Actions against Breast Cancer Cell Line, MCF-7 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A21%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Copper%20Oxide%20Nanoparticle-Decorated%20Carbon%20Nanoparticle%20Composite%20Colloidal%20Preparation%20through%20Laser%20Ablation%20for%20Antimicrobial%20and%20Antiproliferative%20Actions%20against%20Breast%20Cancer%20Cell%20Line,%20MCF-7&rft.jtitle=BioMed%20research%20international&rft.au=Mohammed,%20Salman%20A.%20A.&rft.date=2022&rft.volume=2022&rft.issue=1&rft.spage=9863616&rft.epage=9863616&rft.pages=9863616-9863616&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2022/9863616&rft_dat=%3Cgale_pubme%3EA697642491%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2640852933&rft_id=info:pmid/35299896&rft_galeid=A697642491&rfr_iscdi=true |