Distinguishing immune activation and inflammatory signatures of multisystem inflammatory syndrome in children (MIS-C) versus hemophagocytic lymphohistiocytosis (HLH)

Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening sequela of severe acute respiratory syndrome coronavirus 2 infection characterized by hyperinflammation and multiorgan dysfunction. Although hyperinflammation is a prominent manifestation of MIS-C, there is limit...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2022-05, Vol.149 (5), p.1592-1606.e16
Hauptverfasser:	Kumar, Deepak, Rostad, Christina A., Jaggi, Preeti, Villacis Nunez, D. Sofia, Prince, Chengyu, Lu, Austin, Hussaini, Laila, Nguyen, Thinh H., Malik, Sakshi, Ponder, Lori A., Shenoy, Sreekala P.V., Anderson, Evan J., Briones, Michael, Sanz, Ignacio, Prahalad, Sampath, Chandrakasan, Shanmuganathan
Format:	Artikel
Sprache:	eng
Schlagworte:	cardiac dysfunction Child COVID-19 COVID-19 - complications Cytokines - metabolism HLH Humans hyperinflammation Ligands Lymphohistiocytosis, Hemophagocytic - diagnosis MIS-C Systemic Inflammatory Response Syndrome T-cell activation Vascular Endothelial Growth Factor A
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