Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem cells in a process known as reprogramming. Notably, partial and reversible reprogramming does not change cell identity but can reverse markers of aging in cells,...

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Veröffentlicht in:	Aging cell 2022-03, Vol.21 (3), p.e13578-n/a
Hauptverfasser:	Chondronasiou, Dafni, Gill, Diljeet, Mosteiro, Lluc, Urdinguio, Rocio G., Berenguer‐Llergo, Antonio, Aguilera, Mònica, Durand, Sylvere, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Abad, Maria, Martin‐Herranz, Daniel E., Stephan‐Otto Attolini, Camille, Prats, Neus, Kroemer, Guido, Fraga, Mario F., Reik, Wolf, Serrano, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Animals Cell Differentiation Cellular Reprogramming - genetics DNA damage DNA methylation DNA Methylation - genetics epigenetic clocks Epigenetics Epigenome Induced Pluripotent Stem Cells - metabolism KLF4 protein Metabolomics Mice Myc protein Oct-4 protein OSKM Pancreas Pluripotency Rejuvenation reprogramming Spleen Stem cell transplantation Stem cells Transcription Transcription factors Transcriptomes transcriptomic clocks Transcriptomics Yamanaka
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