Regulation of stem cell identity by miR-200a during spinal cord regeneration

Axolotls are an important model organism for multiple types of regeneration, including functional spinal cord regeneration. Remarkably, axolotls can repair their spinal cord after a small lesion injury and can also regenerate their entire tail following amputation. Several classical signaling pathwa...

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Veröffentlicht in:	Development (Cambridge) 2022-02, Vol.149 (3)
Hauptverfasser:	Walker, Sarah E, Sabin, Keith Z, Gearhart, Micah D, Yamamoto, Kenta, Echeverri, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Ambystoma mexicanum - metabolism Animals Antagomirs - metabolism beta Catenin - antagonists & inhibitors beta Catenin - chemistry beta Catenin - metabolism Cell Differentiation Fetal Proteins - genetics Fetal Proteins - metabolism Mesoderm - cytology Mesoderm - metabolism MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Neural Stem Cells - cytology Neural Stem Cells - metabolism Neuroglia - cytology Neuroglia - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Spinal Cord - cytology Spinal Cord - metabolism Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal Cord Regeneration - genetics Stem Cells - cytology Stem Cells - metabolism Stem Cells and Regeneration T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Tail - physiology Wnt Signaling Pathway
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