Effect of vitamin D source and dietary cation–anion difference in peripartum dairy cows on calcium homeostasis and milk production

Abstract The objective of this experiment was to determine the effects of dietary vitamin D source on serum calcium (Ca), urinary Ca excretion, and milk production when fed in combination with a prepartum acidogenic negative dietary cation–anion difference (DCAD) diet. Nonlactating, pregnant multipa...

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Veröffentlicht in:Translational animal science 2022-01, Vol.6 (1), p.txac010-txac010
Hauptverfasser: Beck, Matthew R, Zapalac, Dakota, Chapman, James D, Zanzalari, K P, Holub, Glenn A, Bascom, Scott S, Engstrom, Mark A, Reuter, R Ryan, Foote, Andrew P
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container_issue 1
container_start_page txac010
container_title Translational animal science
container_volume 6
creator Beck, Matthew R
Zapalac, Dakota
Chapman, James D
Zanzalari, K P
Holub, Glenn A
Bascom, Scott S
Engstrom, Mark A
Reuter, R Ryan
Foote, Andrew P
description Abstract The objective of this experiment was to determine the effects of dietary vitamin D source on serum calcium (Ca), urinary Ca excretion, and milk production when fed in combination with a prepartum acidogenic negative dietary cation–anion difference (DCAD) diet. Nonlactating, pregnant multiparous cows (n = 15), balanced for breed (Holstein n = 9 and Jersey n = 6), and previous mature equivalent milk production, were assigned to one of three treatments (five cows/treatment), consisting of a control (PCH; positive DCAD, 8.9 mEq/100 g DM) and two negative DCAD diets (−15.4 mEq/100 g DM), one with vitamin D3 (cholecalciferol; NCH) and one with 25-hydroxyvitamin D3 (calcidiol; NCA; DSM nutritional products). The treatments were formulated to provide 1.95 mg/d of vitamin D and were fed 28 d prior to expected calving date. Delivery of vitamin D sources was accomplished by manufacture of a pellet and 2 kg of these pellets were individually fed simultaneously each day along with 2 kg of ground corn daily at 0800 hours. Negative DCAD treatments were formulated to provide 0.46 kg/d of Animate (Phibro Animal Health) and, if needed, additional Animate was top-dressed at each feeding to achieve a urine pH between 5.5 and 6.0 based on the previous day’s urine pH. Close-up cows had ad libitum access to chopped bermudagrass (Cynodon dactylon L.) hay and hay intake was measured using SmartFeed Pro systems (C-Lock Inc.; Rapid City, SD). Prepartum urine and serum samples were collected weekly and serum was collected 36, 48, and 72 h post-calving. Prepartum dry matter intake (DMI) as a percent of body weight was not (P = 0.66) affected by treatments. Cows fed NCH and NCA had greater (P = 0.02) prepartum serum Ca than PCH and tended to have greater urinary Ca excretions (P = 0.10). Average postpartum serum Ca (mg/dL) was greater (P = 0.05) for cows fed NCH (8.8) compared with PCH (7.8), whereas NCA (8.4) was numerically intermediate and not (P > 0.05) different from either of the other treatments. Postpartum DMI was not affected by treatment (P = 0.39). Daily milk yield (MY) (kg/d) was greatest (P < 0.01) for NCA (37.5) compared with the other treatments and NCH (34.1) was intermediate and greater than PCH (29.9). These results suggest that an acidogenic prepartum diet in combination with vitamin D was effective in maintaining peripartum serum Ca and the 25-hydroxy form of vitamin D improved MY compared with NCH in early lactation.
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Nonlactating, pregnant multiparous cows (n = 15), balanced for breed (Holstein n = 9 and Jersey n = 6), and previous mature equivalent milk production, were assigned to one of three treatments (five cows/treatment), consisting of a control (PCH; positive DCAD, 8.9 mEq/100 g DM) and two negative DCAD diets (−15.4 mEq/100 g DM), one with vitamin D3 (cholecalciferol; NCH) and one with 25-hydroxyvitamin D3 (calcidiol; NCA; DSM nutritional products). The treatments were formulated to provide 1.95 mg/d of vitamin D and were fed 28 d prior to expected calving date. Delivery of vitamin D sources was accomplished by manufacture of a pellet and 2 kg of these pellets were individually fed simultaneously each day along with 2 kg of ground corn daily at 0800 hours. Negative DCAD treatments were formulated to provide 0.46 kg/d of Animate (Phibro Animal Health) and, if needed, additional Animate was top-dressed at each feeding to achieve a urine pH between 5.5 and 6.0 based on the previous day’s urine pH. Close-up cows had ad libitum access to chopped bermudagrass (Cynodon dactylon L.) hay and hay intake was measured using SmartFeed Pro systems (C-Lock Inc.; Rapid City, SD). Prepartum urine and serum samples were collected weekly and serum was collected 36, 48, and 72 h post-calving. Prepartum dry matter intake (DMI) as a percent of body weight was not (P = 0.66) affected by treatments. Cows fed NCH and NCA had greater (P = 0.02) prepartum serum Ca than PCH and tended to have greater urinary Ca excretions (P = 0.10). Average postpartum serum Ca (mg/dL) was greater (P = 0.05) for cows fed NCH (8.8) compared with PCH (7.8), whereas NCA (8.4) was numerically intermediate and not (P &gt; 0.05) different from either of the other treatments. Postpartum DMI was not affected by treatment (P = 0.39). Daily milk yield (MY) (kg/d) was greatest (P &lt; 0.01) for NCA (37.5) compared with the other treatments and NCH (34.1) was intermediate and greater than PCH (29.9). These results suggest that an acidogenic prepartum diet in combination with vitamin D was effective in maintaining peripartum serum Ca and the 25-hydroxy form of vitamin D improved MY compared with NCH in early lactation.</description><identifier>ISSN: 2573-2102</identifier><identifier>EISSN: 2573-2102</identifier><identifier>DOI: 10.1093/tas/txac010</identifier><identifier>PMID: 35291427</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Alfacalcidol ; Body weight ; Calcifediol ; Dairy cattle ; Dietary supplements industry ; Production data ; Ruminant Nutrition ; Vitamin D</subject><ispartof>Translational animal science, 2022-01, Vol.6 (1), p.txac010-txac010</ispartof><rights>The Author(s) 2022. 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Nonlactating, pregnant multiparous cows (n = 15), balanced for breed (Holstein n = 9 and Jersey n = 6), and previous mature equivalent milk production, were assigned to one of three treatments (five cows/treatment), consisting of a control (PCH; positive DCAD, 8.9 mEq/100 g DM) and two negative DCAD diets (−15.4 mEq/100 g DM), one with vitamin D3 (cholecalciferol; NCH) and one with 25-hydroxyvitamin D3 (calcidiol; NCA; DSM nutritional products). The treatments were formulated to provide 1.95 mg/d of vitamin D and were fed 28 d prior to expected calving date. Delivery of vitamin D sources was accomplished by manufacture of a pellet and 2 kg of these pellets were individually fed simultaneously each day along with 2 kg of ground corn daily at 0800 hours. Negative DCAD treatments were formulated to provide 0.46 kg/d of Animate (Phibro Animal Health) and, if needed, additional Animate was top-dressed at each feeding to achieve a urine pH between 5.5 and 6.0 based on the previous day’s urine pH. Close-up cows had ad libitum access to chopped bermudagrass (Cynodon dactylon L.) hay and hay intake was measured using SmartFeed Pro systems (C-Lock Inc.; Rapid City, SD). Prepartum urine and serum samples were collected weekly and serum was collected 36, 48, and 72 h post-calving. Prepartum dry matter intake (DMI) as a percent of body weight was not (P = 0.66) affected by treatments. Cows fed NCH and NCA had greater (P = 0.02) prepartum serum Ca than PCH and tended to have greater urinary Ca excretions (P = 0.10). Average postpartum serum Ca (mg/dL) was greater (P = 0.05) for cows fed NCH (8.8) compared with PCH (7.8), whereas NCA (8.4) was numerically intermediate and not (P &gt; 0.05) different from either of the other treatments. Postpartum DMI was not affected by treatment (P = 0.39). Daily milk yield (MY) (kg/d) was greatest (P &lt; 0.01) for NCA (37.5) compared with the other treatments and NCH (34.1) was intermediate and greater than PCH (29.9). These results suggest that an acidogenic prepartum diet in combination with vitamin D was effective in maintaining peripartum serum Ca and the 25-hydroxy form of vitamin D improved MY compared with NCH in early lactation.</description><subject>Alfacalcidol</subject><subject>Body weight</subject><subject>Calcifediol</subject><subject>Dairy cattle</subject><subject>Dietary supplements industry</subject><subject>Production data</subject><subject>Ruminant Nutrition</subject><subject>Vitamin D</subject><issn>2573-2102</issn><issn>2573-2102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kk1rFjEQxxex2FJ78i4BQQR52rzsbjYXodT6AoVe9BxmZ5M2upusSbbVmwe_gd_QT2Ien6elBSk5TJj8_n9mJlNVzxg9ZFSJowzpKH8HpIw-qvZ4I8WKM8of37nvVgcpfaGUMqVUy-iTalc0XLGay73q16m1BjMJlly5DJPz5C1JYYloCPiBDM5kiD8IQnbB__n5G3yJJV1k0fhCFcVsopsh5mUiA7g1Ha4TKRjCiK5kL8NkQiq1uvTPdXLjVzLHMCy4tn1a7VgYkznYxv3q87vTTycfVmfn7z-eHJ-tsJYqrwZu7dD2tWGqa63oa-Q9bcAiR0BhWdcy0QEbeiW4lNbKHqSsQXLEDhplxH71ZuM7L_1kBjQ-Rxj1HN1UetQBnL7_4t2lvghXulOsE11TDF5tDWL4tpiU9eQSmnEEb8KSNG9rShvG266gLzboBYxGO29DccQ1ro-lbGTNOiYKdfgfqpzBTA6DN9aV_D3B640AY0gpGntbPaN6vRG6TFlvN6LQz-82fMve_H8BXm6AsMwPOv0FpAXDuQ</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Beck, Matthew R</creator><creator>Zapalac, Dakota</creator><creator>Chapman, James D</creator><creator>Zanzalari, K P</creator><creator>Holub, Glenn A</creator><creator>Bascom, Scott S</creator><creator>Engstrom, Mark A</creator><creator>Reuter, R Ryan</creator><creator>Foote, Andrew P</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8571-5184</orcidid><orcidid>https://orcid.org/0000-0002-7995-1540</orcidid><orcidid>https://orcid.org/0000-0002-8498-7855</orcidid></search><sort><creationdate>20220101</creationdate><title>Effect of vitamin D source and dietary cation–anion difference in peripartum dairy cows on calcium homeostasis and milk production</title><author>Beck, Matthew R ; Zapalac, Dakota ; Chapman, James D ; Zanzalari, K P ; Holub, Glenn A ; Bascom, Scott S ; Engstrom, Mark A ; Reuter, R Ryan ; Foote, Andrew P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-d2ffd6b4e1986f3b4c2b05afc2cac3f186138a1db93277ff7ba774a72cc8a59e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alfacalcidol</topic><topic>Body weight</topic><topic>Calcifediol</topic><topic>Dairy cattle</topic><topic>Dietary supplements industry</topic><topic>Production data</topic><topic>Ruminant Nutrition</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beck, Matthew R</creatorcontrib><creatorcontrib>Zapalac, Dakota</creatorcontrib><creatorcontrib>Chapman, James D</creatorcontrib><creatorcontrib>Zanzalari, K P</creatorcontrib><creatorcontrib>Holub, Glenn A</creatorcontrib><creatorcontrib>Bascom, Scott S</creatorcontrib><creatorcontrib>Engstrom, Mark A</creatorcontrib><creatorcontrib>Reuter, R Ryan</creatorcontrib><creatorcontrib>Foote, Andrew P</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beck, Matthew R</au><au>Zapalac, Dakota</au><au>Chapman, James D</au><au>Zanzalari, K P</au><au>Holub, Glenn A</au><au>Bascom, Scott S</au><au>Engstrom, Mark A</au><au>Reuter, R Ryan</au><au>Foote, Andrew P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin D source and dietary cation–anion difference in peripartum dairy cows on calcium homeostasis and milk production</atitle><jtitle>Translational animal science</jtitle><addtitle>Transl Anim Sci</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>6</volume><issue>1</issue><spage>txac010</spage><epage>txac010</epage><pages>txac010-txac010</pages><issn>2573-2102</issn><eissn>2573-2102</eissn><abstract>Abstract The objective of this experiment was to determine the effects of dietary vitamin D source on serum calcium (Ca), urinary Ca excretion, and milk production when fed in combination with a prepartum acidogenic negative dietary cation–anion difference (DCAD) diet. Nonlactating, pregnant multiparous cows (n = 15), balanced for breed (Holstein n = 9 and Jersey n = 6), and previous mature equivalent milk production, were assigned to one of three treatments (five cows/treatment), consisting of a control (PCH; positive DCAD, 8.9 mEq/100 g DM) and two negative DCAD diets (−15.4 mEq/100 g DM), one with vitamin D3 (cholecalciferol; NCH) and one with 25-hydroxyvitamin D3 (calcidiol; NCA; DSM nutritional products). The treatments were formulated to provide 1.95 mg/d of vitamin D and were fed 28 d prior to expected calving date. Delivery of vitamin D sources was accomplished by manufacture of a pellet and 2 kg of these pellets were individually fed simultaneously each day along with 2 kg of ground corn daily at 0800 hours. Negative DCAD treatments were formulated to provide 0.46 kg/d of Animate (Phibro Animal Health) and, if needed, additional Animate was top-dressed at each feeding to achieve a urine pH between 5.5 and 6.0 based on the previous day’s urine pH. Close-up cows had ad libitum access to chopped bermudagrass (Cynodon dactylon L.) hay and hay intake was measured using SmartFeed Pro systems (C-Lock Inc.; Rapid City, SD). Prepartum urine and serum samples were collected weekly and serum was collected 36, 48, and 72 h post-calving. Prepartum dry matter intake (DMI) as a percent of body weight was not (P = 0.66) affected by treatments. Cows fed NCH and NCA had greater (P = 0.02) prepartum serum Ca than PCH and tended to have greater urinary Ca excretions (P = 0.10). Average postpartum serum Ca (mg/dL) was greater (P = 0.05) for cows fed NCH (8.8) compared with PCH (7.8), whereas NCA (8.4) was numerically intermediate and not (P &gt; 0.05) different from either of the other treatments. Postpartum DMI was not affected by treatment (P = 0.39). Daily milk yield (MY) (kg/d) was greatest (P &lt; 0.01) for NCA (37.5) compared with the other treatments and NCH (34.1) was intermediate and greater than PCH (29.9). These results suggest that an acidogenic prepartum diet in combination with vitamin D was effective in maintaining peripartum serum Ca and the 25-hydroxy form of vitamin D improved MY compared with NCH in early lactation.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>35291427</pmid><doi>10.1093/tas/txac010</doi><orcidid>https://orcid.org/0000-0001-8571-5184</orcidid><orcidid>https://orcid.org/0000-0002-7995-1540</orcidid><orcidid>https://orcid.org/0000-0002-8498-7855</orcidid><oa>free_for_read</oa></addata></record>
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subjects Alfacalcidol
Body weight
Calcifediol
Dairy cattle
Dietary supplements industry
Production data
Ruminant Nutrition
Vitamin D
title Effect of vitamin D source and dietary cation–anion difference in peripartum dairy cows on calcium homeostasis and milk production
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