Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach

Background and Objectives Besides allergic reactions, antibodies against polyethylene glycol (PEG) have been associated with reduced PEG-asparaginase (PEG-ASNase) activity. Population pharmacokinetics (popPK) allow for an in-depth investigation of the influence of anti-PEG antibodies on PEG-ASNase p...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 2022-03, Vol.47 (2), p.187-198
Hauptverfasser:	Siebel, Christian, Lanvers-Kaminsky, Claudia, Alten, Julia, Smisek, Petr, Nath, Christa E., Rizzari, Carmelo, Boos, Joachim, Würthwein, Gudrun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents Asparaginase Biomedical and Life Sciences Biomedicine Child Human Physiology Humans Medical Biochemistry Original Original Research Article Pharmaceutical Sciences/Technology Pharmacology/Toxicology Pharmacy Polyethylene Glycols - pharmacokinetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
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