Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin

Previous studies have reported that phosphodiesterase 10A (PDE10) is overexpressed in colon epithelium during early stages of colon tumorigenesis and essential for colon cancer cell growth. Here we describe a novel non-COX inhibitory derivative of the anti-inflammatory drug, sulindac, with selective...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2021-11, Vol.14 (11), p.995-1008
Hauptverfasser:	Lee, Kevin J, Chang, Wen-Chi L, Chen, Xi, Valiyaveettil, Jacob, Ramirez-Alcantara, Veronica, Gavin, Elaine, Musiyenko, Alla, Madeira da Silva, Luciana, Annamdevula, Naga S, Leavesley, Silas J, Ward, Antonio, Mattox, Tyler, Lindsey, Ashley S, Andrews, Joel, Zhu, Bing, Wood, Charles, Neese, Ashleigh, Nguyen, Ashley, Berry, Kristy, Maxuitenko, Yulia, Moyer, Mary Pat, Nurmemmedov, Elmar, Gorman, Greg, Coward, Lori, Zhou, Gang, Keeton, Adam B, Cooper, Harry S, Clapper, Margie L, Piazza, Gary A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin Carcinogenesis Colon - pathology Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - prevention & control Mice Phosphodiesterase Inhibitors - pharmacology Sulindac - pharmacology
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