O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling

SignificanceEpidermal growth factor receptor (EGFR) is one of the most important membrane receptors that transduce growth signals into cells to sustain cell growth, proliferation, and survival. EGFR signal termination is initiated by EGFR internalization, followed by trafficking through endosomes, a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-03, Vol.119 (10), p.e2107453119-e2107453119
Hauptverfasser:	Wu, Liming, Cheng, Yaxian, Geng, Didi, Fan, Zhiya, Lin, Bingyi, Zhu, Qiang, Li, Jingchao, Qin, Weijie, Yi, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation - genetics Adaptor proteins Biological Sciences Cancer Cell growth Cell proliferation Cell survival Chemoresistance Degradation Deregulation Endosomes - genetics Endosomes - metabolism Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Glycosylation Growth factors Hep G2 Cells Hepatocyte growth factor Hepatocytes Humans Intracellular Intracellular signalling Kinases Lysosomes Lysosomes - genetics Lysosomes - metabolism N-Acetylglucosamine O-GlcNAcylation Protein transport Protein Transport - genetics Protein-tyrosine kinase receptors Proteins Receptors Signal Transduction Signaling Substrates Tumors Tyrosine Ubiquitination Xenografts Xenotransplantation
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