Protein-Based Hydrogels: Promising Materials for Tissue Engineering
The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents' structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to ach...
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| Veröffentlicht in: | Polymers 2022-02, Vol.14 (5), p.986 |
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| container_title | Polymers |
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| creator | Davari, Niyousha Bakhtiary, Negar Khajehmohammadi, Mehran Sarkari, Soulmaz Tolabi, Hamidreza Ghorbani, Farnaz Ghalandari, Behafarid |
| description | The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents' structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to achieve the best network structure necessary for the formation of the hydrogel with desired properties, the failure rate of tissue engineering projects will be significantly reduced. In this review, we examine the behavior of proteins as an essential and effective component of hydrogels, and describe the factors that can enhance the protein-based hydrogels' structure. Furthermore, we outline the fabrication route of protein-based hydrogels from protein microstructure and the selection of appropriate materials according to recent research to growth factors, crucial members of the protein family, and their delivery approaches. Finally, the unmet needs and current challenges in developing the ideal biomaterials for protein-based hydrogels are discussed, and emerging strategies in this area are highlighted. |
| doi_str_mv | 10.3390/polym14050986 |
| format | Article |
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If the engineered processes are in line with the procedures that natural materials undergo to achieve the best network structure necessary for the formation of the hydrogel with desired properties, the failure rate of tissue engineering projects will be significantly reduced. In this review, we examine the behavior of proteins as an essential and effective component of hydrogels, and describe the factors that can enhance the protein-based hydrogels' structure. Furthermore, we outline the fabrication route of protein-based hydrogels from protein microstructure and the selection of appropriate materials according to recent research to growth factors, crucial members of the protein family, and their delivery approaches. Finally, the unmet needs and current challenges in developing the ideal biomaterials for protein-based hydrogels are discussed, and emerging strategies in this area are highlighted.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym14050986</identifier><identifier>PMID: 35267809</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biocompatibility ; Biomedical materials ; Failure rates ; Growth factors ; Hyaluronic acid ; Hydrogels ; Hydrogen bonds ; Investigations ; Materials selection ; Mechanical properties ; Polyethylene glycol ; Polyvinyl alcohol ; Proteins ; Review ; Tissue engineering</subject><ispartof>Polymers, 2022-02, Vol.14 (5), p.986</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Biocompatibility Biomedical materials Failure rates Growth factors Hyaluronic acid Hydrogels Hydrogen bonds Investigations Materials selection Mechanical properties Polyethylene glycol Polyvinyl alcohol Proteins Review Tissue engineering |
| title | Protein-Based Hydrogels: Promising Materials for Tissue Engineering |
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