Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis

Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to diabetic complications. The underlying mechanism, however, remains elusive. We previously demonstrated as a susceptibility gene for type 2 diabetes mellitus (T2DM) and showed that it was increased in multiple tis...

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Veröffentlicht in:	International journal of molecular sciences 2022-03, Vol.23 (5), p.2879
Hauptverfasser:	Wan, Yiqi, Liu, Zhirui, Wu, Andong, Khan, Abdul Haseeb, Zhu, Ying, Ding, Shuangjin, Li, Xueer, Zhao, Ya, Dai, Ximo, Zhou, Jin, Liu, Jiankun, Li, Yuanyuan, Gong, Xueting, Liu, Man, Tian, Xiao-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biological activity Biological Phenomena Caenorhabditis elegans Cardiovascular disease Cell activation Cell cycle Cell growth Cells, Cultured Cellular Senescence - genetics Datasets Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Endothelial cells Galactosidase Genes Glucose Human Umbilical Vein Endothelial Cells - metabolism Humans Hyperglycemia Hyperglycemia - genetics Hyperglycemia - metabolism Innate immunity Metabolic disorders Metabolic syndrome Phenotypes Proteins Rats Senescence Smooth muscle Transcriptomics Tumor necrosis factor-α Umbilical vein β-Galactosidase
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