The Efficacy of Cannabis in Reducing Back Pain: A Systematic Review
Objective To critically analyze the evidence and efficacy of cannabis to treat surgical and nonsurgical back pain via a Systematic Review. Methods We conducted a systematic review to investigate the efficacy of cannabis to treat non-surgical and surgical back pain. A literature search was performed...
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| Veröffentlicht in: | Global Spine Journal 2022-02, Vol.12 (2), p.343-352 |
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| creator | Price, Richard L. Charlot, Kaarina V. Frieler, Sven Dettori, Joseph R. Oskouian, Rod Chapman, Jens R. |
| description | Objective
To critically analyze the evidence and efficacy of cannabis to treat surgical and nonsurgical back pain via a Systematic Review.
Methods
We conducted a systematic review to investigate the efficacy of cannabis to treat non-surgical and surgical back pain. A literature search was performed with MEDLINE and Embase databases. Only RCTs and prospective cohort studies with concurrent control were included in this study. Risk of bias and quality grading was assessed for each included study.
Results
Database searches returned 1738 non-duplicated results. An initial screening excluded 1716 results. Twenty-two full text articles were assessed for eligibility. Four articles ultimately met pre-determined eligibility and were included in the study. Two studies addressed post-SCI pain while other two studies addressed low back pain. No studies specifically examined the use of cannabis for surgical back pain. The type of cannabis varied between study and included THC, dronabinol, and Nabilone. A total of 110 patients were included in the four studies reviewed. In each study, there was a quantifiable advantage of cannabis therapy for alleviating back pain. There were no serious adverse effects reported.
Conclusions
In all articles, cannabis was shown to be effective to treat back pain with an acceptable side effect profile. However, long-term follow up is lacking. As medicinal cannabis is being used more commonly for analgesic effect and patients are “self-prescribing” cannabis for back pain, additional studies are needed for healthcare providers to confidently recommend cannabis therapy for back pain.
Study Design
Systematic review. |
| doi_str_mv | 10.1177/21925682211065411 |
| format | Article |
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To critically analyze the evidence and efficacy of cannabis to treat surgical and nonsurgical back pain via a Systematic Review.
Methods
We conducted a systematic review to investigate the efficacy of cannabis to treat non-surgical and surgical back pain. A literature search was performed with MEDLINE and Embase databases. Only RCTs and prospective cohort studies with concurrent control were included in this study. Risk of bias and quality grading was assessed for each included study.
Results
Database searches returned 1738 non-duplicated results. An initial screening excluded 1716 results. Twenty-two full text articles were assessed for eligibility. Four articles ultimately met pre-determined eligibility and were included in the study. Two studies addressed post-SCI pain while other two studies addressed low back pain. No studies specifically examined the use of cannabis for surgical back pain. The type of cannabis varied between study and included THC, dronabinol, and Nabilone. A total of 110 patients were included in the four studies reviewed. In each study, there was a quantifiable advantage of cannabis therapy for alleviating back pain. There were no serious adverse effects reported.
Conclusions
In all articles, cannabis was shown to be effective to treat back pain with an acceptable side effect profile. However, long-term follow up is lacking. As medicinal cannabis is being used more commonly for analgesic effect and patients are “self-prescribing” cannabis for back pain, additional studies are needed for healthcare providers to confidently recommend cannabis therapy for back pain.
Study Design
Systematic review.</description><identifier>ISSN: 2192-5682</identifier><identifier>EISSN: 2192-5690</identifier><identifier>DOI: 10.1177/21925682211065411</identifier><identifier>PMID: 35128969</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Back pain ; EBSJ - Review ; Medical marijuana ; Pain management ; Systematic review</subject><ispartof>Global Spine Journal, 2022-02, Vol.12 (2), p.343-352</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is licensed under the Creative Commons Attribution – Non-Commercial – No Derivatives License https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022 2022 AO Spine, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-437ca7606f667c651ee38e7121d77d1d5dab4f4c7a4b8a33294ac1808dadf2ba3</citedby><cites>FETCH-LOGICAL-c466t-437ca7606f667c651ee38e7121d77d1d5dab4f4c7a4b8a33294ac1808dadf2ba3</cites><orcidid>0000-0002-0216-8363 ; 0000-0002-7261-2028</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907633/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907633/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,727,780,784,792,864,885,21966,27853,27922,27924,27925,44945,45333,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35128969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Price, Richard L.</creatorcontrib><creatorcontrib>Charlot, Kaarina V.</creatorcontrib><creatorcontrib>Frieler, Sven</creatorcontrib><creatorcontrib>Dettori, Joseph R.</creatorcontrib><creatorcontrib>Oskouian, Rod</creatorcontrib><creatorcontrib>Chapman, Jens R.</creatorcontrib><title>The Efficacy of Cannabis in Reducing Back Pain: A Systematic Review</title><title>Global Spine Journal</title><addtitle>Global Spine J</addtitle><description>Objective
To critically analyze the evidence and efficacy of cannabis to treat surgical and nonsurgical back pain via a Systematic Review.
Methods
We conducted a systematic review to investigate the efficacy of cannabis to treat non-surgical and surgical back pain. A literature search was performed with MEDLINE and Embase databases. Only RCTs and prospective cohort studies with concurrent control were included in this study. Risk of bias and quality grading was assessed for each included study.
Results
Database searches returned 1738 non-duplicated results. An initial screening excluded 1716 results. Twenty-two full text articles were assessed for eligibility. Four articles ultimately met pre-determined eligibility and were included in the study. Two studies addressed post-SCI pain while other two studies addressed low back pain. No studies specifically examined the use of cannabis for surgical back pain. The type of cannabis varied between study and included THC, dronabinol, and Nabilone. A total of 110 patients were included in the four studies reviewed. In each study, there was a quantifiable advantage of cannabis therapy for alleviating back pain. There were no serious adverse effects reported.
Conclusions
In all articles, cannabis was shown to be effective to treat back pain with an acceptable side effect profile. However, long-term follow up is lacking. As medicinal cannabis is being used more commonly for analgesic effect and patients are “self-prescribing” cannabis for back pain, additional studies are needed for healthcare providers to confidently recommend cannabis therapy for back pain.
Study Design
Systematic review.</description><subject>Back pain</subject><subject>EBSJ - Review</subject><subject>Medical marijuana</subject><subject>Pain management</subject><subject>Systematic review</subject><issn>2192-5682</issn><issn>2192-5690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kcFOGzEQhq0KVBDkAXqpLHHhEtixd8deDpUgogUJCdSmZ2vW6w2GxEvXu6ny9nUUGqAVnoNHnm9-z-hn7BNkJwBKnQooRYFaCIAMixzgA9tfv40LLLOdba7FHhvF-JClg0JJEB_ZnixA6BLLfTaZ3jt-2TTekl3xtuETCoEqH7kP_LurB-vDjF-QfeR35MMZP-c_VrF3C-q9TcDSu9-HbLeheXSj5_uA_fx6OZ1cjW9uv11Pzm_GNkfsx7lUlhRm2CAqiwU4J7VTIKBWqoa6qKnKm9wqyitNUooyJws60zXVjahIHrAvG92noVq42rrQdzQ3T51fULcyLXnzthL8vZm1S6PLTKGUSeD4WaBrfw0u9mbho3XzOQXXDtEITCE0Ckjo0T_oQzt0Ia2XKJmGRoQ1BRvKdm2MnWu2w0Bm1i6Z_1xKPZ9fb7Ht-OtJAk42QKSZe_n2fcU__dWX9w</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Price, Richard L.</creator><creator>Charlot, Kaarina V.</creator><creator>Frieler, Sven</creator><creator>Dettori, Joseph R.</creator><creator>Oskouian, Rod</creator><creator>Chapman, Jens R.</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0216-8363</orcidid><orcidid>https://orcid.org/0000-0002-7261-2028</orcidid></search><sort><creationdate>20220201</creationdate><title>The Efficacy of Cannabis in Reducing Back Pain: A Systematic Review</title><author>Price, Richard L. ; Charlot, Kaarina V. ; Frieler, Sven ; Dettori, Joseph R. ; Oskouian, Rod ; Chapman, Jens R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-437ca7606f667c651ee38e7121d77d1d5dab4f4c7a4b8a33294ac1808dadf2ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Back pain</topic><topic>EBSJ - Review</topic><topic>Medical marijuana</topic><topic>Pain management</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Price, Richard L.</creatorcontrib><creatorcontrib>Charlot, Kaarina V.</creatorcontrib><creatorcontrib>Frieler, Sven</creatorcontrib><creatorcontrib>Dettori, Joseph R.</creatorcontrib><creatorcontrib>Oskouian, Rod</creatorcontrib><creatorcontrib>Chapman, Jens R.</creatorcontrib><collection>SAGE Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Global Spine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Price, Richard L.</au><au>Charlot, Kaarina V.</au><au>Frieler, Sven</au><au>Dettori, Joseph R.</au><au>Oskouian, Rod</au><au>Chapman, Jens R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Efficacy of Cannabis in Reducing Back Pain: A Systematic Review</atitle><jtitle>Global Spine Journal</jtitle><addtitle>Global Spine J</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>12</volume><issue>2</issue><spage>343</spage><epage>352</epage><pages>343-352</pages><issn>2192-5682</issn><eissn>2192-5690</eissn><abstract>Objective
To critically analyze the evidence and efficacy of cannabis to treat surgical and nonsurgical back pain via a Systematic Review.
Methods
We conducted a systematic review to investigate the efficacy of cannabis to treat non-surgical and surgical back pain. A literature search was performed with MEDLINE and Embase databases. Only RCTs and prospective cohort studies with concurrent control were included in this study. Risk of bias and quality grading was assessed for each included study.
Results
Database searches returned 1738 non-duplicated results. An initial screening excluded 1716 results. Twenty-two full text articles were assessed for eligibility. Four articles ultimately met pre-determined eligibility and were included in the study. Two studies addressed post-SCI pain while other two studies addressed low back pain. No studies specifically examined the use of cannabis for surgical back pain. The type of cannabis varied between study and included THC, dronabinol, and Nabilone. A total of 110 patients were included in the four studies reviewed. In each study, there was a quantifiable advantage of cannabis therapy for alleviating back pain. There were no serious adverse effects reported.
Conclusions
In all articles, cannabis was shown to be effective to treat back pain with an acceptable side effect profile. However, long-term follow up is lacking. As medicinal cannabis is being used more commonly for analgesic effect and patients are “self-prescribing” cannabis for back pain, additional studies are needed for healthcare providers to confidently recommend cannabis therapy for back pain.
Study Design
Systematic review.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>35128969</pmid><doi>10.1177/21925682211065411</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0216-8363</orcidid><orcidid>https://orcid.org/0000-0002-7261-2028</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2192-5682 |
| ispartof | Global Spine Journal, 2022-02, Vol.12 (2), p.343-352 |
| issn | 2192-5682 2192-5690 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8907633 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SAGE Journals |
| subjects | Back pain EBSJ - Review Medical marijuana Pain management Systematic review |
| title | The Efficacy of Cannabis in Reducing Back Pain: A Systematic Review |
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