STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages

Objectives. Although a recent study reported that stimulator of interferon genes (STING) in macrophages has an important regulatory effect on liver ischemia-reperfusion injury (IRI), the underlying mechanism of STING-dependent innate immune activation in liver macrophages (Kupffer cells, KCs) remain...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.8123157-19
Hauptverfasser:	Wu, Xin-yi, Chen, Ya-jun, Liu, Chang-an, Gong, Jun-hua, Xu, Xue-song
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood vessels Caspase 1 - metabolism Cytokines Humans Inflammation Ischemia Liver Liver - pathology Macrophages - metabolism Male Mice Microscopy Phosphate-Binding Proteins - metabolism Pore Forming Cytotoxic Proteins - metabolism Reperfusion Injury - physiopathology Signal Transduction Spleen Transfection
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