Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients

Osteosarcoma (OS) is a genetically diverse bone cancer that lacks a consistent targetable mutation. Recent studies suggest the IGF/PI3K/mTOR pathway and YAP/TAZ paralogs regulate cell fate and proliferation in response to biomechanical cues within the tumor microenvironment. How this occurs and thei...

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Veröffentlicht in:	Oncotarget 2022, Vol.13 (1), p.521-533
Hauptverfasser:	Molina, Eric R, Chim, Letitia K, Lamhamedi-Cherradi, Salah-Eddine, Mohiuddin, Sana, McCall, David, Cuglievan, Branko, Krishnan, Sandhya, Porter, Robert W, Ingram, Davis R, Wang, Wei-Lien, Lazar, Alexander J, Scott, David W, Truong, Danh D, Daw, Najat C, Ludwig, Joseph A, Mikos, Antonios G
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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