A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

Effective drugs against SARS-CoV-2 are urgently needed to treat severe cases of infection and for prophylactic use. The main viral protease (nsp5 or 3CLpro) represents an attractive and possibly broad-spectrum target for drug development as it is essential to the virus life cycle and highly conserve...

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Veröffentlicht in:	Antiviral research 2022-05, Vol.201, p.105272-105272, Article 105272
Hauptverfasser:	Chen, K.Y., Krischuns, T., Varga, L. Ortega, Harigua-Souiai, E., Paisant, S., Zettor, A., Chiaravalli, J., Delpal, A., Courtney, D., O'Brien, A., Baker, S.C., Decroly, E., Isel, C., Agou, F., Jacob, Y., Blondel, A., Naffakh, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	3CLpro Antiviral Agents - chemistry Antiviral Agents - pharmacology Biochemistry, Molecular Biology Cell-based assay COVID-19 Drug Treatment High-throughput screening Humans Life Sciences Luciferases - genetics Microbiology and Parasitology Molecular biology Molecular Docking Simulation nsp5 Peptide Hydrolases Protease Inhibitors - pharmacology SARS-CoV-2 Small molecule inhibitors Viral Proteases Virology
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