Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classifica...

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Veröffentlicht in:	Nature reviews. Microbiology 2020-02, Vol.18 (2), p.67-83
Hauptverfasser:	Makarova, Kira S., Wolf, Yuri I., Iranzo, Jaime, Shmakov, Sergey A., Alkhnbashi, Omer S., Brouns, Stan J. J., Charpentier, Emmanuelle, Cheng, David, Haft, Daniel H., Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J. M., Scott, David, Shah, Shiraz A., Siksnys, Virginijus, Terns, Michael P., Venclovas, Česlovas, White, Malcolm F., Yakunin, Alexander F., Yan, Winston, Zhang, Feng, Garrett, Roger A., Backofen, Rolf, van der Oost, John, Barrangou, Rodolphe, Koonin, Eugene V.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/181/2474 631/181/735 631/250/2152 631/326/1321 631/326/26/2526 631/326/325 631/326/4041 631/326/41/2530 Adaptive immunity Archaea - genetics Bacteria - genetics Biological evolution Biomedical and Life Sciences Classification CRISPR CRISPR-Cas Systems - genetics CRISPR-Cas Systems - physiology Evolution, Molecular Evolutionary genetics Gene Expression Regulation, Archaeal - physiology Gene Expression Regulation, Bacterial - physiology Genes Infectious Diseases Life Sciences Medical Microbiology Microbiology Nuclease Parasitology Review Article Ribonucleic acid RNA Signal transduction Transposition Virology
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