Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability

Genome integrity requires complete and accurate DNA replication once per cell division cycle. Replication stress poses obstacles to this process that must be overcome to prevent replication fork collapse. An important regulator of replication fork stability is the RAD51 protein, which promotes repli...

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Veröffentlicht in:	The Journal of biological chemistry 2022-03, Vol.298 (3), p.101672-101672, Article 101672
Hauptverfasser:	Mohamed, Taha, Adolph, Madison B., Cortez, David
Format:	Artikel
Sprache:	eng
Schlagworte:	cxorf57 dimerization DNA combing DNA repair DNA Replication DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism fork protection fork reversal genome stability Genomic Instability Humans RAD51 Rad51 Recombinase - genetics Rad51 Recombinase - metabolism RADX RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RPA Transcription Factors - genetics
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