A lysine-rich cluster in the N-BAR domain of ARF GTPase-activating protein ASAP1 is necessary for binding and bundling actin filaments

Actin filament maintenance is critical for both normal cell homeostasis and events associated with malignant transformation. The ADP-ribosylation factor GTPase-activating protein ASAP1 regulates the dynamics of filamentous actin-based structures, including stress fibers, focal adhesions, and circula...

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Veröffentlicht in:	The Journal of biological chemistry 2022-03, Vol.298 (3), p.101700-101700, Article 101700
Hauptverfasser:	Gasilina, Anjelika, Yoon, Hye-Young, Jian, Xiaoying, Luo, Ruibai, Randazzo, Paul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism actin-binding protein Actins Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism ADP ribosylation factor ADP-Ribosylation Factors - metabolism ArfGAP cytoskeleton GTPase activating protein GTPase-Activating Proteins - metabolism Lysine - metabolism microfilaments Nerve Tissue Proteins - metabolism Protein Binding Protein Domains stress fibers
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