Interstitial Lung Disease and Transverse Myelitis: A Possible Complication of COVID-19 Vaccine
The clinical impact of the severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic is growing, and vaccine-associated complications are becoming more evident. Although global vaccination against coronavirus disease 19 (COVID-19) is an outstanding accomplishment, safety concerns and adverse outcome...
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Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-02, Vol.14 (2), p.e21875 |
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description | The clinical impact of the severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic is growing, and vaccine-associated complications are becoming more evident. Although global vaccination against coronavirus disease 19 (COVID-19) is an outstanding accomplishment, safety concerns and adverse outcomes are also emerging that need to be addressed promptly. The most reported side effects of the COVID-19 vaccine include fever, myalgia, headache, and injection site reactions. Acute transverse myelitis (ATM) and interstitial lung disease (ILD) following the CoronaVac vaccine are rarely reported. We report a case of ILD followed by acute myelopathy in a female who presented with dyspnea, cough, and fever after the second dose of the COVID-19 vaccine. On the third day of admission, she developed paresthesia and bilateral upper and lower limb weakness. She was diagnosed with ILD and ATM due to the COVID-19 vaccine based on imaging and detailed investigations after ruling out all possible causes. Her neurological and respiratory manifestations improved gradually after starting intravenous methylprednisolone. |
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Although global vaccination against coronavirus disease 19 (COVID-19) is an outstanding accomplishment, safety concerns and adverse outcomes are also emerging that need to be addressed promptly. The most reported side effects of the COVID-19 vaccine include fever, myalgia, headache, and injection site reactions. Acute transverse myelitis (ATM) and interstitial lung disease (ILD) following the CoronaVac vaccine are rarely reported. We report a case of ILD followed by acute myelopathy in a female who presented with dyspnea, cough, and fever after the second dose of the COVID-19 vaccine. On the third day of admission, she developed paresthesia and bilateral upper and lower limb weakness. She was diagnosed with ILD and ATM due to the COVID-19 vaccine based on imaging and detailed investigations after ruling out all possible causes. Her neurological and respiratory manifestations improved gradually after starting intravenous methylprednisolone.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.21875</identifier><identifier>PMID: 35273846</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Antibodies ; Antigens ; Asthma ; Case reports ; Coronaviruses ; COVID-19 vaccines ; Dehydrogenases ; Disease transmission ; Drug dosages ; Dyspnea ; Etiology ; Hospitals ; Hypertension ; Immune system ; Infectious Disease ; Inflammatory diseases ; Internal Medicine ; Lung diseases ; Lungs ; Magnetic resonance imaging ; Proteins ; Pulmonology ; Respiratory distress syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Spinal cord ; Tomography ; Viruses ; West Nile virus</subject><ispartof>Curēus (Palo Alto, CA), 2022-02, Vol.14 (2), p.e21875</ispartof><rights>Copyright © 2022, Khan et al.</rights><rights>Copyright © 2022, Khan et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Khan et al. 2022 Khan et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-a1102b88184792fd9d3d854b0353bc6fad6a5c7e55c0e6223ba67ed6ee75e9cc3</citedby><cites>FETCH-LOGICAL-c309t-a1102b88184792fd9d3d854b0353bc6fad6a5c7e55c0e6223ba67ed6ee75e9cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901165/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901165/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35273846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Zunaira</creatorcontrib><creatorcontrib>Khattak, Ahmad Ammar</creatorcontrib><creatorcontrib>Rafiq, Nawal</creatorcontrib><creatorcontrib>Amin, Anam</creatorcontrib><creatorcontrib>Abdullah, Mahwish</creatorcontrib><title>Interstitial Lung Disease and Transverse Myelitis: A Possible Complication of COVID-19 Vaccine</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>The clinical impact of the severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic is growing, and vaccine-associated complications are becoming more evident. Although global vaccination against coronavirus disease 19 (COVID-19) is an outstanding accomplishment, safety concerns and adverse outcomes are also emerging that need to be addressed promptly. The most reported side effects of the COVID-19 vaccine include fever, myalgia, headache, and injection site reactions. Acute transverse myelitis (ATM) and interstitial lung disease (ILD) following the CoronaVac vaccine are rarely reported. We report a case of ILD followed by acute myelopathy in a female who presented with dyspnea, cough, and fever after the second dose of the COVID-19 vaccine. On the third day of admission, she developed paresthesia and bilateral upper and lower limb weakness. She was diagnosed with ILD and ATM due to the COVID-19 vaccine based on imaging and detailed investigations after ruling out all possible causes. Her neurological and respiratory manifestations improved gradually after starting intravenous methylprednisolone.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Asthma</subject><subject>Case reports</subject><subject>Coronaviruses</subject><subject>COVID-19 vaccines</subject><subject>Dehydrogenases</subject><subject>Disease transmission</subject><subject>Drug dosages</subject><subject>Dyspnea</subject><subject>Etiology</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Immune system</subject><subject>Infectious Disease</subject><subject>Inflammatory diseases</subject><subject>Internal Medicine</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Magnetic resonance imaging</subject><subject>Proteins</subject><subject>Pulmonology</subject><subject>Respiratory distress syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Spinal cord</subject><subject>Tomography</subject><subject>Viruses</subject><subject>West Nile virus</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkc1LAzEQxYMoWqo3zxLw6tZ8NMmuB6HUr0JFD9qjIZudrZFttia7Bf97t7YWPc3A_HjzeA-hU0oGSons0rYB2jhgNFViD_UYlWmS0nS4_2c_QicxfhBCKFGMKHKIjrhgiqdD2UNvE99AiI1rnKnwtPVzfOMimAjY-AK_BOPjqgMAP35B1VHxCo_wcx2jyyvA43qxrJw1jas9rks8fppNbhKa4Zmx1nk4RgelqSKcbGcfvd7dvowfkunT_WQ8miaWk6xJDKWE5enarcpYWWQFL1IxzAkXPLeyNIU0wioQwhKQjPHcSAWFBFACMmt5H11vdJdtvoDCgm-CqfQyuIUJX7o2Tv-_ePeu5_VKpxmhVIpO4HwrEOrPFmKjP-o2-M6zZnIolBCKso662FA2dAkEKHcfKNHrQvSmEP1TSIef_XW1g3_j598pOIhV</recordid><startdate>20220203</startdate><enddate>20220203</enddate><creator>Khan, Zunaira</creator><creator>Khattak, Ahmad Ammar</creator><creator>Rafiq, Nawal</creator><creator>Amin, Anam</creator><creator>Abdullah, Mahwish</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20220203</creationdate><title>Interstitial Lung Disease and Transverse Myelitis: A Possible Complication of COVID-19 Vaccine</title><author>Khan, Zunaira ; Khattak, Ahmad Ammar ; Rafiq, Nawal ; Amin, Anam ; Abdullah, Mahwish</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-a1102b88184792fd9d3d854b0353bc6fad6a5c7e55c0e6223ba67ed6ee75e9cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies</topic><topic>Antigens</topic><topic>Asthma</topic><topic>Case reports</topic><topic>Coronaviruses</topic><topic>COVID-19 vaccines</topic><topic>Dehydrogenases</topic><topic>Disease transmission</topic><topic>Drug dosages</topic><topic>Dyspnea</topic><topic>Etiology</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Immune system</topic><topic>Infectious Disease</topic><topic>Inflammatory diseases</topic><topic>Internal Medicine</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Magnetic resonance imaging</topic><topic>Proteins</topic><topic>Pulmonology</topic><topic>Respiratory distress syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Spinal cord</topic><topic>Tomography</topic><topic>Viruses</topic><topic>West Nile virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Zunaira</creatorcontrib><creatorcontrib>Khattak, Ahmad Ammar</creatorcontrib><creatorcontrib>Rafiq, Nawal</creatorcontrib><creatorcontrib>Amin, Anam</creatorcontrib><creatorcontrib>Abdullah, Mahwish</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Zunaira</au><au>Khattak, Ahmad Ammar</au><au>Rafiq, Nawal</au><au>Amin, Anam</au><au>Abdullah, Mahwish</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interstitial Lung Disease and Transverse Myelitis: A Possible Complication of COVID-19 Vaccine</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2022-02-03</date><risdate>2022</risdate><volume>14</volume><issue>2</issue><spage>e21875</spage><pages>e21875-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>The clinical impact of the severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic is growing, and vaccine-associated complications are becoming more evident. 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subjects | Antibodies Antigens Asthma Case reports Coronaviruses COVID-19 vaccines Dehydrogenases Disease transmission Drug dosages Dyspnea Etiology Hospitals Hypertension Immune system Infectious Disease Inflammatory diseases Internal Medicine Lung diseases Lungs Magnetic resonance imaging Proteins Pulmonology Respiratory distress syndrome Severe acute respiratory syndrome coronavirus 2 Spinal cord Tomography Viruses West Nile virus |
title | Interstitial Lung Disease and Transverse Myelitis: A Possible Complication of COVID-19 Vaccine |
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