Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

The spatial organization of immune cells within the tumor microenvironment (TME) largely determines the anti-tumor immunity and also highly predicts tumor progression and therapeutic response. Tim-3 is a well-accepted immune checkpoint and plays multifaceted immunoregulatory roles via interaction wi...

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Veröffentlicht in:	Molecular therapy 2022-03, Vol.30 (3), p.1135-1148
Hauptverfasser:	Wang, Tixiao, Zhang, Jie, Li, Na, Li, Mengzhen, Ma, Shuaiya, Tan, Siyu, Guo, Xiaowei, Wang, Zehua, Wu, Zhuanchang, Gao, Lifen, Ma, Chunhong, Liang, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - therapy CD8-Positive T-Lymphocytes Hepatitis A Virus Cellular Receptor 2 - genetics Hepatitis A Virus Cellular Receptor 2 - metabolism Humans immune checkpoint blockade Ligands Liver Neoplasms multiplexed immunofluorescence Original Tim-3 Tim-3 ligands Tumor Microenvironment
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