Heterologous Catalysis of the Final Steps of Tetracycline Biosynthesis by Saccharomyces cerevisiae

Developing treatments for antibiotic resistant bacterial infections is among the highest priority public health challenges worldwide. Tetracyclines, one of the most important classes of antibiotics, have fallen prey to antibiotic resistance, necessitating the generation of new analogs. Many tetracyc...

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Veröffentlicht in:	ACS chemical biology 2021-08, Vol.16 (8), p.1425-1434
Hauptverfasser:	Herbst, Ehud, Lee, Arden, Tang, Yi, Snyder, Scott A, Cornish, Virginia W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - metabolism Anti-Bacterial Agents - biosynthesis Fungal Proteins - metabolism Hydroxylation Mixed Function Oxygenases - metabolism NADH, NADPH Oxidoreductases - metabolism Oxidation-Reduction Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - metabolism Tetracycline - biosynthesis Tetracyclines - chemistry Tetracyclines - metabolism
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