Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia

Oxidative stress in cardiac disease promotes proarrhythmic disturbances in Ca homeostasis, impairing luminal Ca regulation of the sarcoplasmic reticulum (SR) Ca release channel, the RyR2 (ryanodine receptor), and increasing channel activity. However, exact mechanisms underlying redox-mediated increa...

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Veröffentlicht in:	Circulation research 2022-03, Vol.130 (5), p.711-724
Hauptverfasser:	Hamilton, Shanna, Terentyeva, Radmila, Bogdanov, Vladimir, Kim, Tae Yun, Perger, Fruzsina, Yan, Jiajie, Ai, Xun, Carnes, Cynthia A., Belevych, Andriy E., George, Christopher H., Davis, Jonathan P., Gyorke, Sandor, Choi, Bum-Rak, Terentyev, Dmitry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - metabolism Calcium - metabolism Calcium Signaling Heart Diseases - metabolism Intracellular Signaling Peptides and Proteins - metabolism Isoproterenol - pharmacology Membrane Glycoproteins - metabolism Myocytes, Cardiac - metabolism Original Research Oxidoreductases - metabolism Oxidoreductases - pharmacology Rats Reactive Oxygen Species - metabolism Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism
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