Exosomes: A Tool for Bone Tissue Engineering
Mesenchymal stem cells (MSCs) have been repeatedly shown to be a valuable source for cell-based therapy in regenerative medicine, including bony tissue repair. However, engraftment at the injury site is poor. Recently, it has been suggested that MSCs and other cells act through a paracrine signaling...
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| Veröffentlicht in: | Tissue engineering. Part B, Reviews Reviews, 2022-02, Vol.28 (1), p.11-113 |
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| creator | Huber, Julika Griffin, Michelle F Longaker, Michael T Quarto, Natalina |
| description | Mesenchymal stem cells (MSCs) have been repeatedly shown to be a valuable source for cell-based therapy in regenerative medicine, including bony tissue repair. However, engraftment at the injury site is poor. Recently, it has been suggested that MSCs and other cells act through a paracrine signaling mechanism. Exosomes are nanostructures that have been implicated in this process. They carry DNA, RNA, proteins, and lipids and play an important role in cell-to-cell communication directly modulating their target cell at a transcriptional level. In a bone microenvironment, they have been shown to increase osteogenesis and osteogenic differentiation
in vivo
and
in vitro
. In the following review, we will discuss the most advanced and significant knowledge of biological functions of exosomes in bone regeneration and their clinical applications in osseous diseases. |
| doi_str_mv | 10.1089/ten.teb.2020.0246 |
| format | Article |
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in vivo
and
in vitro
. In the following review, we will discuss the most advanced and significant knowledge of biological functions of exosomes in bone regeneration and their clinical applications in osseous diseases.</description><identifier>ISSN: 1937-3368</identifier><identifier>EISSN: 1937-3376</identifier><identifier>DOI: 10.1089/ten.teb.2020.0246</identifier><identifier>PMID: 33297857</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Bone growth ; Bones ; Cell Differentiation ; Cell interactions ; Engraftment ; Exosomes ; Exosomes - metabolism ; Immunogenicity ; Lipids ; Mesenchymal Stem Cells ; Mesenchyme ; Microenvironments ; mRNA ; Osteogenesis ; Paracrine signalling ; Regenerative Medicine ; Review ; Review Articles ; Stem cells ; Tissue Engineering ; Transcription</subject><ispartof>Tissue engineering. Part B, Reviews, 2022-02, Vol.28 (1), p.11-113</ispartof><rights>2022, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright Mary Ann Liebert, Inc. Feb 2022</rights><rights>Copyright 2022, Mary Ann Liebert, Inc., publishers 2022 Mary Ann Liebert, Inc., publishers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-988a3777913ad372d78f2f22f1be74bd6564554cb11ca5112a7360b19f49006f3</citedby><cites>FETCH-LOGICAL-c523t-988a3777913ad372d78f2f22f1be74bd6564554cb11ca5112a7360b19f49006f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33297857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huber, Julika</creatorcontrib><creatorcontrib>Griffin, Michelle F</creatorcontrib><creatorcontrib>Longaker, Michael T</creatorcontrib><creatorcontrib>Quarto, Natalina</creatorcontrib><title>Exosomes: A Tool for Bone Tissue Engineering</title><title>Tissue engineering. Part B, Reviews</title><addtitle>Tissue Eng Part B Rev</addtitle><description>Mesenchymal stem cells (MSCs) have been repeatedly shown to be a valuable source for cell-based therapy in regenerative medicine, including bony tissue repair. However, engraftment at the injury site is poor. Recently, it has been suggested that MSCs and other cells act through a paracrine signaling mechanism. Exosomes are nanostructures that have been implicated in this process. They carry DNA, RNA, proteins, and lipids and play an important role in cell-to-cell communication directly modulating their target cell at a transcriptional level. In a bone microenvironment, they have been shown to increase osteogenesis and osteogenic differentiation
in vivo
and
in vitro
. In the following review, we will discuss the most advanced and significant knowledge of biological functions of exosomes in bone regeneration and their clinical applications in osseous diseases.</description><subject>Bone growth</subject><subject>Bones</subject><subject>Cell Differentiation</subject><subject>Cell interactions</subject><subject>Engraftment</subject><subject>Exosomes</subject><subject>Exosomes - metabolism</subject><subject>Immunogenicity</subject><subject>Lipids</subject><subject>Mesenchymal Stem Cells</subject><subject>Mesenchyme</subject><subject>Microenvironments</subject><subject>mRNA</subject><subject>Osteogenesis</subject><subject>Paracrine signalling</subject><subject>Regenerative Medicine</subject><subject>Review</subject><subject>Review Articles</subject><subject>Stem cells</subject><subject>Tissue Engineering</subject><subject>Transcription</subject><issn>1937-3368</issn><issn>1937-3376</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1LwzAYhYMoTqc_wBspeGtrPtp8eCHMMT9g4M28DmmbzI4umUkr-u9N2Rx650VIeHPOeQ8PABcIZghycdNpm3W6zDDEMIM4pwfgBAnCUkIYPdy_KR-B0xBWEFJIGT8GI0KwYLxgJ-B69umCW-twm0yShXNtYpxP7p3VyaIJodfJzC4bq7Vv7PIMHBnVBn2-u8fg9WG2mD6l85fH5-lknlYFJl0qOFeEMSYQUTVhuGbcYIOxQaVmeVnTguZFkVclQpUqEMKKEQpLJEwuYkdDxuBum7vpy7WuK207r1q58c1a-S_pVCP__tjmTS7dh-RcYFGwGHC1C_DuvdehkyvXexs7S0yxQIhRlkcV2qoq70Lw2uw3ICgHwDICjqeUA2A5AI6ey9_V9o4folHAtoJhrKxtG11q3_0j-hvzPIlw</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Huber, Julika</creator><creator>Griffin, Michelle F</creator><creator>Longaker, Michael T</creator><creator>Quarto, Natalina</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>20220201</creationdate><title>Exosomes: A Tool for Bone Tissue Engineering</title><author>Huber, Julika ; Griffin, Michelle F ; Longaker, Michael T ; Quarto, Natalina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-988a3777913ad372d78f2f22f1be74bd6564554cb11ca5112a7360b19f49006f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bone growth</topic><topic>Bones</topic><topic>Cell Differentiation</topic><topic>Cell interactions</topic><topic>Engraftment</topic><topic>Exosomes</topic><topic>Exosomes - metabolism</topic><topic>Immunogenicity</topic><topic>Lipids</topic><topic>Mesenchymal Stem Cells</topic><topic>Mesenchyme</topic><topic>Microenvironments</topic><topic>mRNA</topic><topic>Osteogenesis</topic><topic>Paracrine signalling</topic><topic>Regenerative Medicine</topic><topic>Review</topic><topic>Review Articles</topic><topic>Stem cells</topic><topic>Tissue Engineering</topic><topic>Transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huber, Julika</creatorcontrib><creatorcontrib>Griffin, Michelle F</creatorcontrib><creatorcontrib>Longaker, Michael T</creatorcontrib><creatorcontrib>Quarto, Natalina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Tissue engineering. Part B, Reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huber, Julika</au><au>Griffin, Michelle F</au><au>Longaker, Michael T</au><au>Quarto, Natalina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exosomes: A Tool for Bone Tissue Engineering</atitle><jtitle>Tissue engineering. Part B, Reviews</jtitle><addtitle>Tissue Eng Part B Rev</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>28</volume><issue>1</issue><spage>11</spage><epage>113</epage><pages>11-113</pages><issn>1937-3368</issn><eissn>1937-3376</eissn><abstract>Mesenchymal stem cells (MSCs) have been repeatedly shown to be a valuable source for cell-based therapy in regenerative medicine, including bony tissue repair. However, engraftment at the injury site is poor. Recently, it has been suggested that MSCs and other cells act through a paracrine signaling mechanism. Exosomes are nanostructures that have been implicated in this process. They carry DNA, RNA, proteins, and lipids and play an important role in cell-to-cell communication directly modulating their target cell at a transcriptional level. In a bone microenvironment, they have been shown to increase osteogenesis and osteogenic differentiation
in vivo
and
in vitro
. In the following review, we will discuss the most advanced and significant knowledge of biological functions of exosomes in bone regeneration and their clinical applications in osseous diseases.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>33297857</pmid><doi>10.1089/ten.teb.2020.0246</doi><tpages>103</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1937-3368 |
| ispartof | Tissue engineering. Part B, Reviews, 2022-02, Vol.28 (1), p.11-113 |
| issn | 1937-3368 1937-3376 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bone growth Bones Cell Differentiation Cell interactions Engraftment Exosomes Exosomes - metabolism Immunogenicity Lipids Mesenchymal Stem Cells Mesenchyme Microenvironments mRNA Osteogenesis Paracrine signalling Regenerative Medicine Review Review Articles Stem cells Tissue Engineering Transcription |
| title | Exosomes: A Tool for Bone Tissue Engineering |
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