The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue
Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL)....
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description | Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL). This study hypothesized that NRL treatment a potential ameliorate nephrotoxicity and cardiotoxicity caused by TAA.
Thirty-two Wistar Albino male rats (3-4 months old and 280-300 g in weight) were divided into four groups. (a) Control, (b) TAA was administered 200 mg/kg
twice a weekly (c) NRL was orally administered at the dose of 100 mg/kg
every other day by gavages. (d) TAA and NRL-treated groups were assigned 200 mg/kg TAA and 100 mg/kg NRL for three weeks.
As a result of these dose administration thiobarbituric acid reactive substances (TBARS) levels, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) levels were detected. The results were shown that TAA leads to a significant rise in TBARS level and a significant decrease in GPx, CAT, SOD, and GSH levels in the heart and kidney tissue according to the control group. The finding of this study the NRL treatment reduced TBARS levels and increased antioxidant level. Administration of NRL prevents the biochemical and histopathological alterations induced by TAA.
The findings of this study show that the antioxidant activity of NRL can protect against biochemical and histological damage caused by TAA in heart and kidney tissue. |
doi_str_mv | 10.4274/tjps.galenos.2021.30806 |
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Thirty-two Wistar Albino male rats (3-4 months old and 280-300 g in weight) were divided into four groups. (a) Control, (b) TAA was administered 200 mg/kg
twice a weekly (c) NRL was orally administered at the dose of 100 mg/kg
every other day by gavages. (d) TAA and NRL-treated groups were assigned 200 mg/kg TAA and 100 mg/kg NRL for three weeks.
As a result of these dose administration thiobarbituric acid reactive substances (TBARS) levels, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) levels were detected. The results were shown that TAA leads to a significant rise in TBARS level and a significant decrease in GPx, CAT, SOD, and GSH levels in the heart and kidney tissue according to the control group. The finding of this study the NRL treatment reduced TBARS levels and increased antioxidant level. Administration of NRL prevents the biochemical and histopathological alterations induced by TAA.
The findings of this study show that the antioxidant activity of NRL can protect against biochemical and histological damage caused by TAA in heart and kidney tissue.</description><identifier>ISSN: 1304-530X</identifier><identifier>EISSN: 2148-6247</identifier><identifier>DOI: 10.4274/tjps.galenos.2021.30806</identifier><identifier>PMID: 35227035</identifier><language>eng</language><publisher>Turkey: Galenos Publishing House</publisher><subject>Antioxidants ; Edema ; Enzymes ; Free radicals ; Gene expression ; Heart ; Hemorrhage ; Herbal medicine ; Investigations ; Laboratory animals ; Lipid peroxidation ; Lipids ; Oils & fats ; Original ; Oxidative stress</subject><ispartof>Turkish journal of pharmaceutical sciences, 2022-02, Vol.19 (1), p.1-8</ispartof><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2022 Turk J Pharm Sci, Published by Galenos Publishing House. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3902-3210 ; 0000-0001-5755-3560 ; 0000-0003-4226-674X ; 0000-0001-5566-8321 ; 0000-0003-2907-2019</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892551/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892551/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35227035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Türkmen, Neşe Başak</creatorcontrib><creatorcontrib>Yüce, Hande</creatorcontrib><creatorcontrib>Taşlıdere, Aslı</creatorcontrib><creatorcontrib>Şahin, Yasemin</creatorcontrib><creatorcontrib>Çiftçi, Osman</creatorcontrib><title>The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue</title><title>Turkish journal of pharmaceutical sciences</title><addtitle>Turk J Pharm Sci</addtitle><description>Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL). This study hypothesized that NRL treatment a potential ameliorate nephrotoxicity and cardiotoxicity caused by TAA.
Thirty-two Wistar Albino male rats (3-4 months old and 280-300 g in weight) were divided into four groups. (a) Control, (b) TAA was administered 200 mg/kg
twice a weekly (c) NRL was orally administered at the dose of 100 mg/kg
every other day by gavages. (d) TAA and NRL-treated groups were assigned 200 mg/kg TAA and 100 mg/kg NRL for three weeks.
As a result of these dose administration thiobarbituric acid reactive substances (TBARS) levels, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) levels were detected. The results were shown that TAA leads to a significant rise in TBARS level and a significant decrease in GPx, CAT, SOD, and GSH levels in the heart and kidney tissue according to the control group. The finding of this study the NRL treatment reduced TBARS levels and increased antioxidant level. Administration of NRL prevents the biochemical and histopathological alterations induced by TAA.
The findings of this study show that the antioxidant activity of NRL can protect against biochemical and histological damage caused by TAA in heart and kidney tissue.</description><subject>Antioxidants</subject><subject>Edema</subject><subject>Enzymes</subject><subject>Free radicals</subject><subject>Gene expression</subject><subject>Heart</subject><subject>Hemorrhage</subject><subject>Herbal medicine</subject><subject>Investigations</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Oils & fats</subject><subject>Original</subject><subject>Oxidative stress</subject><issn>1304-530X</issn><issn>2148-6247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1v1DAQhi0EoqvSvwCWuHDJ4o9x7FyQqlIooqKXReIWTeLJrleJvcRORf89kSgIOM1hHr3zjF7GXkmxBWXhbTme8naPI8WUt0ooudXCifoJ2ygJrqoV2KdsI7WAymjx7Yxd5HwUQshGa-vgOTvTRikrtNmww-5A_HKiMaQZC_HrYaC-ZJ4G_oXmNAafRp4i3x1Cwp4KTsFTFaJfevL87kfwWMI98fc44Z54iPyGcC4co-efg4_0wHch54VesGcDjpkuHuc5-_rhend1U93effx0dXlbnZSCUknXAdQOhUJAbTqorfSiWV072ymq-wGEVN4Z0TkvydbSNqJD0Q8NNKrW-py9-5V7WrqJfE-xzDi2pzlMOD-0CUP77yaGQ7tP961zjTJGrgFvHgPm9H2hXNop5J7GESOlJbfrEXBgG1Ar-vo_9JiWOa7vrRQIY1Y3t1Iv_zb6o_K7BP0TwjWNLg</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Türkmen, Neşe Başak</creator><creator>Yüce, Hande</creator><creator>Taşlıdere, Aslı</creator><creator>Şahin, Yasemin</creator><creator>Çiftçi, Osman</creator><general>Galenos Publishing House</general><general>Galenos Publishing</general><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3902-3210</orcidid><orcidid>https://orcid.org/0000-0001-5755-3560</orcidid><orcidid>https://orcid.org/0000-0003-4226-674X</orcidid><orcidid>https://orcid.org/0000-0001-5566-8321</orcidid><orcidid>https://orcid.org/0000-0003-2907-2019</orcidid></search><sort><creationdate>20220201</creationdate><title>The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue</title><author>Türkmen, Neşe Başak ; Yüce, Hande ; Taşlıdere, Aslı ; Şahin, Yasemin ; Çiftçi, Osman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p224t-18b4468a02a4a35b4671d09035b7b2e6cf4012d850b8d1e761790ba0cf9492633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants</topic><topic>Edema</topic><topic>Enzymes</topic><topic>Free radicals</topic><topic>Gene expression</topic><topic>Heart</topic><topic>Hemorrhage</topic><topic>Herbal medicine</topic><topic>Investigations</topic><topic>Laboratory animals</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Oils & fats</topic><topic>Original</topic><topic>Oxidative stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Türkmen, Neşe Başak</creatorcontrib><creatorcontrib>Yüce, Hande</creatorcontrib><creatorcontrib>Taşlıdere, Aslı</creatorcontrib><creatorcontrib>Şahin, Yasemin</creatorcontrib><creatorcontrib>Çiftçi, Osman</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Turkish journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Türkmen, Neşe Başak</au><au>Yüce, Hande</au><au>Taşlıdere, Aslı</au><au>Şahin, Yasemin</au><au>Çiftçi, Osman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue</atitle><jtitle>Turkish journal of pharmaceutical sciences</jtitle><addtitle>Turk J Pharm Sci</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>19</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1304-530X</issn><eissn>2148-6247</eissn><abstract>Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL). This study hypothesized that NRL treatment a potential ameliorate nephrotoxicity and cardiotoxicity caused by TAA.
Thirty-two Wistar Albino male rats (3-4 months old and 280-300 g in weight) were divided into four groups. (a) Control, (b) TAA was administered 200 mg/kg
twice a weekly (c) NRL was orally administered at the dose of 100 mg/kg
every other day by gavages. (d) TAA and NRL-treated groups were assigned 200 mg/kg TAA and 100 mg/kg NRL for three weeks.
As a result of these dose administration thiobarbituric acid reactive substances (TBARS) levels, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) levels were detected. The results were shown that TAA leads to a significant rise in TBARS level and a significant decrease in GPx, CAT, SOD, and GSH levels in the heart and kidney tissue according to the control group. The finding of this study the NRL treatment reduced TBARS levels and increased antioxidant level. Administration of NRL prevents the biochemical and histopathological alterations induced by TAA.
The findings of this study show that the antioxidant activity of NRL can protect against biochemical and histological damage caused by TAA in heart and kidney tissue.</abstract><cop>Turkey</cop><pub>Galenos Publishing House</pub><pmid>35227035</pmid><doi>10.4274/tjps.galenos.2021.30806</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3902-3210</orcidid><orcidid>https://orcid.org/0000-0001-5755-3560</orcidid><orcidid>https://orcid.org/0000-0003-4226-674X</orcidid><orcidid>https://orcid.org/0000-0001-5566-8321</orcidid><orcidid>https://orcid.org/0000-0003-2907-2019</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Antioxidants Edema Enzymes Free radicals Gene expression Heart Hemorrhage Herbal medicine Investigations Laboratory animals Lipid peroxidation Lipids Oils & fats Original Oxidative stress |
title | The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue |
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