A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment
Prolonged exposure to high altitudes above 2500 m above sea level (a.s.l.) can cause cognitive and behavioral dysfunctions. Herein, we sought to investigate the effects of chronic exposure to plateau hypoxia on the hippocampus in a rat model by using voxel-based morphometry, creatine chemical exchan...
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| Veröffentlicht in: | Neurochemical research 2022-04, Vol.47 (4), p.979-1000 |
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| creator | Zhu, Dongyong He, Bo Zhang, Mengdi Wan, Yixuan Liu, Ruibin Wang, Lei Zhang, Yi Li, Yunqing Gao, Fabao |
| description | Prolonged exposure to high altitudes above 2500 m above sea level (a.s.l.) can cause cognitive and behavioral dysfunctions. Herein, we sought to investigate the effects of chronic exposure to plateau hypoxia on the hippocampus in a rat model by using voxel-based morphometry, creatine chemical exchange saturation transfer (CrCEST) and dynamic contrast-enhanced MR imaging techniques. 58 healthy 4-week-old male rats were randomized into plateau hypoxia rats (H group) as the experimental group and plain rats (P group) as the control group. H group rats were transported from Chengdu (500 m a.s.l.), a city in a plateau located in southwestern China, to the Qinghai–Tibet Plateau (4250 m a.s.l.), Yushu, China, and then fed for 8 months there, while P group rats were fed in Chengdu (500 m a.s.l.), China. After 8 months of exposure to plateau hypoxia, open-field and elevated plus maze tests revealed that the anxiety-like behavior of the H group rats was more serious than that of the P group rats, and the Morris water maze test revealed impaired spatial memory function in the H group rats. Multimodal MR imaging analysis revealed a decreased volume of the regional gray matter, lower CrCEST contrast and higher transport coefficient Ktrans in the hippocampus compared with the P group rats. Further correlation analysis found associations of quantitative MRI parameters of the hippocampus with the behavioral performance of H group rats. In this study, we validated the viability of using noninvasive multimodal MR imaging techniques to evaluate the effects of chronic exposure to a plateau hypoxic environment on the hippocampus. |
| doi_str_mv | 10.1007/s11064-021-03498-5 |
| format | Article |
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Herein, we sought to investigate the effects of chronic exposure to plateau hypoxia on the hippocampus in a rat model by using voxel-based morphometry, creatine chemical exchange saturation transfer (CrCEST) and dynamic contrast-enhanced MR imaging techniques. 58 healthy 4-week-old male rats were randomized into plateau hypoxia rats (H group) as the experimental group and plain rats (P group) as the control group. H group rats were transported from Chengdu (500 m a.s.l.), a city in a plateau located in southwestern China, to the Qinghai–Tibet Plateau (4250 m a.s.l.), Yushu, China, and then fed for 8 months there, while P group rats were fed in Chengdu (500 m a.s.l.), China. After 8 months of exposure to plateau hypoxia, open-field and elevated plus maze tests revealed that the anxiety-like behavior of the H group rats was more serious than that of the P group rats, and the Morris water maze test revealed impaired spatial memory function in the H group rats. Multimodal MR imaging analysis revealed a decreased volume of the regional gray matter, lower CrCEST contrast and higher transport coefficient Ktrans in the hippocampus compared with the P group rats. Further correlation analysis found associations of quantitative MRI parameters of the hippocampus with the behavioral performance of H group rats. In this study, we validated the viability of using noninvasive multimodal MR imaging techniques to evaluate the effects of chronic exposure to a plateau hypoxic environment on the hippocampus.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-021-03498-5</identifier><identifier>PMID: 34981302</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Anxiety ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Chronic exposure ; Cognition ; Cognitive ability ; Correlation analysis ; Creatine ; Exposure ; High altitude ; Hippocampus ; Hippocampus - diagnostic imaging ; Hypoxia ; Hypoxia - complications ; Imaging techniques ; Magnetic Resonance Imaging ; Male ; Maze Learning ; Memory Disorders - etiology ; Memory tasks ; Morphometry ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Rats ; Rodents ; Sea level ; Spatial analysis ; Spatial memory ; Substantia grisea ; Transport properties</subject><ispartof>Neurochemical research, 2022-04, Vol.47 (4), p.979-1000</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-7a5823132aa454bda444042d58a3fc606228299b0577b5844be69a572d916b933</citedby><cites>FETCH-LOGICAL-c474t-7a5823132aa454bda444042d58a3fc606228299b0577b5844be69a572d916b933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-021-03498-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-021-03498-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34981302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Dongyong</creatorcontrib><creatorcontrib>He, Bo</creatorcontrib><creatorcontrib>Zhang, Mengdi</creatorcontrib><creatorcontrib>Wan, Yixuan</creatorcontrib><creatorcontrib>Liu, Ruibin</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Li, Yunqing</creatorcontrib><creatorcontrib>Gao, Fabao</creatorcontrib><title>A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Prolonged exposure to high altitudes above 2500 m above sea level (a.s.l.) can cause cognitive and behavioral dysfunctions. Herein, we sought to investigate the effects of chronic exposure to plateau hypoxia on the hippocampus in a rat model by using voxel-based morphometry, creatine chemical exchange saturation transfer (CrCEST) and dynamic contrast-enhanced MR imaging techniques. 58 healthy 4-week-old male rats were randomized into plateau hypoxia rats (H group) as the experimental group and plain rats (P group) as the control group. H group rats were transported from Chengdu (500 m a.s.l.), a city in a plateau located in southwestern China, to the Qinghai–Tibet Plateau (4250 m a.s.l.), Yushu, China, and then fed for 8 months there, while P group rats were fed in Chengdu (500 m a.s.l.), China. After 8 months of exposure to plateau hypoxia, open-field and elevated plus maze tests revealed that the anxiety-like behavior of the H group rats was more serious than that of the P group rats, and the Morris water maze test revealed impaired spatial memory function in the H group rats. Multimodal MR imaging analysis revealed a decreased volume of the regional gray matter, lower CrCEST contrast and higher transport coefficient Ktrans in the hippocampus compared with the P group rats. Further correlation analysis found associations of quantitative MRI parameters of the hippocampus with the behavioral performance of H group rats. In this study, we validated the viability of using noninvasive multimodal MR imaging techniques to evaluate the effects of chronic exposure to a plateau hypoxic environment on the hippocampus.</description><subject>Animals</subject><subject>Anxiety</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Chronic exposure</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Correlation analysis</subject><subject>Creatine</subject><subject>Exposure</subject><subject>High altitude</subject><subject>Hippocampus</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hypoxia</subject><subject>Hypoxia - complications</subject><subject>Imaging techniques</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Maze Learning</subject><subject>Memory Disorders - etiology</subject><subject>Memory tasks</subject><subject>Morphometry</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sea level</subject><subject>Spatial analysis</subject><subject>Spatial memory</subject><subject>Substantia grisea</subject><subject>Transport properties</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1v1DAQhiMEokvhD3BAlrhwCfgziS9Iq-32Q-oKVOBsTRIn6yqxg-2s6N_hl9a7W8rHgZM1fp95Z0YzWfaa4PcE4_JDIAQXPMeU5JhxWeXiSbYgomR5ITF7mi0wSzIjEp9kL0K4xTilUfI8O9nThGG6yH4u0WYeohldCwPa3KCrEXpje_Qlzu0dch2KW43WXaebuI8uzTS5BsYp0WeQWI2cRcuDbnYagW3RyvXWHKLz2aZvZwMyFgG6gYg2rtXD3mm19c6aBq1_TC7MXqPoEvJ5gKhhRmu7M0kftY0vs2cdDEG_enhPs2_n66-ry_z608XVanmdN7zkMS9BVJQRRgG44HULnHPMaSsqYF1T4ILSikpZY1GWtag4r3UhQZS0laSoJWOn2cej7zTXo26bVNrDoCZvRvB3yoFRfyvWbFXvdqqqJKGEJIN3DwbefZ91iGo0odHDAFa7OShakKIguJI8oW__QW_d7G0aL1FMJIiKKlH0SDXeheB199gMwWp_Aup4AiptVR1OQImU9ObPMR5Tfu08AewIhCTZXvvftf9jew-H67xA</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Zhu, Dongyong</creator><creator>He, Bo</creator><creator>Zhang, Mengdi</creator><creator>Wan, Yixuan</creator><creator>Liu, Ruibin</creator><creator>Wang, Lei</creator><creator>Zhang, Yi</creator><creator>Li, Yunqing</creator><creator>Gao, Fabao</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220401</creationdate><title>A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment</title><author>Zhu, Dongyong ; He, Bo ; Zhang, Mengdi ; Wan, Yixuan ; Liu, Ruibin ; Wang, Lei ; Zhang, Yi ; Li, Yunqing ; Gao, Fabao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-7a5823132aa454bda444042d58a3fc606228299b0577b5844be69a572d916b933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Anxiety</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Chronic exposure</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Correlation analysis</topic><topic>Creatine</topic><topic>Exposure</topic><topic>High altitude</topic><topic>Hippocampus</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hypoxia</topic><topic>Hypoxia - complications</topic><topic>Imaging techniques</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Maze Learning</topic><topic>Memory Disorders - etiology</topic><topic>Memory tasks</topic><topic>Morphometry</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sea level</topic><topic>Spatial analysis</topic><topic>Spatial memory</topic><topic>Substantia grisea</topic><topic>Transport properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Dongyong</creatorcontrib><creatorcontrib>He, Bo</creatorcontrib><creatorcontrib>Zhang, Mengdi</creatorcontrib><creatorcontrib>Wan, Yixuan</creatorcontrib><creatorcontrib>Liu, Ruibin</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Li, Yunqing</creatorcontrib><creatorcontrib>Gao, Fabao</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Dongyong</au><au>He, Bo</au><au>Zhang, Mengdi</au><au>Wan, Yixuan</au><au>Liu, Ruibin</au><au>Wang, Lei</au><au>Zhang, Yi</au><au>Li, Yunqing</au><au>Gao, Fabao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>47</volume><issue>4</issue><spage>979</spage><epage>1000</epage><pages>979-1000</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Prolonged exposure to high altitudes above 2500 m above sea level (a.s.l.) can cause cognitive and behavioral dysfunctions. Herein, we sought to investigate the effects of chronic exposure to plateau hypoxia on the hippocampus in a rat model by using voxel-based morphometry, creatine chemical exchange saturation transfer (CrCEST) and dynamic contrast-enhanced MR imaging techniques. 58 healthy 4-week-old male rats were randomized into plateau hypoxia rats (H group) as the experimental group and plain rats (P group) as the control group. H group rats were transported from Chengdu (500 m a.s.l.), a city in a plateau located in southwestern China, to the Qinghai–Tibet Plateau (4250 m a.s.l.), Yushu, China, and then fed for 8 months there, while P group rats were fed in Chengdu (500 m a.s.l.), China. After 8 months of exposure to plateau hypoxia, open-field and elevated plus maze tests revealed that the anxiety-like behavior of the H group rats was more serious than that of the P group rats, and the Morris water maze test revealed impaired spatial memory function in the H group rats. Multimodal MR imaging analysis revealed a decreased volume of the regional gray matter, lower CrCEST contrast and higher transport coefficient Ktrans in the hippocampus compared with the P group rats. Further correlation analysis found associations of quantitative MRI parameters of the hippocampus with the behavioral performance of H group rats. In this study, we validated the viability of using noninvasive multimodal MR imaging techniques to evaluate the effects of chronic exposure to a plateau hypoxic environment on the hippocampus.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34981302</pmid><doi>10.1007/s11064-021-03498-5</doi><tpages>22</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anxiety Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Chronic exposure Cognition Cognitive ability Correlation analysis Creatine Exposure High altitude Hippocampus Hippocampus - diagnostic imaging Hypoxia Hypoxia - complications Imaging techniques Magnetic Resonance Imaging Male Maze Learning Memory Disorders - etiology Memory tasks Morphometry Neurochemistry Neurology Neurosciences Original Paper Rats Rodents Sea level Spatial analysis Spatial memory Substantia grisea Transport properties |
| title | A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment |
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