ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA lesions. DNA damage-induced binding of the TCR-specific repair factor CSB to RNA polymerase II (RNAPII) triggers RNAPII ubiquitylation of a single lysine (K1268) by the CRL4 CSA ubiquitin ligase. How CRL4 CSA is...

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Veröffentlicht in:	Nature cell biology 2021-06, Vol.23 (6), p.595-607
Hauptverfasser:	van der Weegen, Yana, de Lint, Klaas, van den Heuvel, Diana, Nakazawa, Yuka, Mevissen, Tycho E. T., van Schie, Janne J. M., San Martin Alonso, Marta, Boer, Daphne E. C., González-Prieto, Román, Narayanan, Ishwarya V., Klaassen, Noud H. M., Wondergem, Annelotte P., Roohollahi, Khashayar, Dorsman, Josephine C., Hara, Yuichiro, Vertegaal, Alfred C. O., de Lange, Job, Walter, Johannes C., Noordermeer, Sylvie M., Ljungman, Mats, Ogi, Tomoo, Wolthuis, Rob M. F., Luijsterburg, Martijn S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 38 45 631/337/1427 631/337/151 631/337/572 631/80/458/582 82 Biomedical and Life Sciences Cancer Research Cell Biology Cell Line, Tumor Cellular stress response CRISPR-Cas Systems Deoxyribonucleic acid Developmental Biology DNA DNA biosynthesis DNA Damage DNA Helicases - genetics DNA Helicases - metabolism DNA Repair DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA-directed RNA polymerase Elongation Genetic screening Humans Life Sciences Lysine Molecular modelling Peptide Elongation Factor 1 - genetics Peptide Elongation Factor 1 - metabolism Poly-ADP-Ribose Binding Proteins - genetics Poly-ADP-Ribose Binding Proteins - metabolism Protein Binding Protein Interaction Domains and Motifs R-loops Repair Replication Ribonucleic acid RNA RNA polymerase RNA polymerase II RNA Polymerase II - genetics RNA Polymerase II - metabolism Stem Cells Transcription Elongation, Genetic Transcription Factors - genetics Transcription Factors - metabolism Transcription-coupled repair Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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