Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Hedgehog (Hh) is a morphogen that binds to its receptor Patched 1 and activates Smoothened (SMO), thereby governing embryonic development and postnatal tissue homeostasis. Cholesterol can bind and covalently conjugate to the luminal cysteine-rich domain (CRD) of human SMO at the D95 residue (D99 in...

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Veröffentlicht in:	Cell research 2022-03, Vol.32 (3), p.288-301
Hauptverfasser:	Hu, Ao, Zhang, Jing-Zan, Wang, Jie, Li, Chen-Chen, Yuan, Meng, Deng, Gang, Lin, Zi-Cun, Qiu, Zhi-Ping, Liu, Hu-Yue, Wang, Xian-Wei, Wei, Peng-Cheng, He, Xiao, Zhao, Xiaolu, Qiu, Wen-Wei, Song, Bao-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 14/19 45/77 631/337/458 631/80/86/2370 82/83 96/35 Animals Biomedical and Life Sciences Calcium Calcium signalling Cell Biology Cholesterol Embryogenesis Embryonic growth stage Endosomes Esters Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Homeostasis Life Sciences Mice Mutation Reaction mechanisms Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction Signaling Smoothened Receptor - genetics Smoothened Receptor - metabolism
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